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Gene

PLAAT3

phospholipase A and acyltransferase 3

Summary

Cytogenetic location
11q12.3-q13.1
Coordinates
Chromosome 11: 63,574,462–63,614,433 (GRCh38)
Exons
5 exons across 40 kb
Protein
162 amino acids
Also known as
HREV107, H-REV107-1, HREV107-3, MGC118754., AdPLA, PLAAT-3
Previous symbols
HRASLS3, PLA2G16
MANE Select transcript
ENST00000415826.3NM_001128203.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Lipodystrophy

    • Familial Partial Lipodystrophy

      Includes the LMNA (Dunnigan), PPARG, PLIN1, LIPE, AKT2, CAV1 and PLAAT3 forms, which cause loss of fat from the limbs and buttocks with insulin resistance, diabetes, high triglycerides and fatty liver.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Knowing allows early screening and treatment of diabetes, triglycerides and liver disease, and in selected cases metreleptin.

How PLAAT3 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 11, with a bracket where PLAAT3 sits. PLAAT3 and 19 genes near it on chromosome 11, from 63,094,448 to 64,094,447.Chromosome 1111q12.3-q13.1p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q2563.2 Mb63.4 Mb63.6 Mb63.8 Mb64 MbSLC22A24: 63,077,406–63,144,221, reverse strandSLC22A24SLC22A25: 63,158,437–63,243,788, reverse strandSLC22A25SLC22A10: 63,268,022–63,311,874, forward strandSLC22A10SLC22A9: 63,369,217–63,411,798, forward strandSLC22A9PLAAT5: 63,461,404–63,491,228, reverse strandPLAAT5LGALS12: 63,505,966–63,519,767, forward strandLGALS12PLAAT4: 63,529,451–63,549,076, forward strandPLAAT4PLAAT2: 63,552,770–63,564,157, reverse strandPLAAT2PLAAT3: 63,574,462–63,614,433, reverse strandPLAAT3ATL3: 63,624,087–63,671,921, reverse strandATL3RTN3: 63,681,444–63,759,909, forward strandRTN3ZFTA: 63,759,892–63,769,752, reverse strandZFTASPINDOC: 63,813,405–63,827,718, forward strandSPINDOCMARK2: 63,838,852–63,911,020, forward strandMARK2RCOR2: 63,910,992–63,919,787, reverse strandRCOR2NAA40: 63,938,669–63,957,324, forward strandNAA40COX8A: 63,974,579–63,976,543, forward strandCOX8AOTUB1: 63,985,853–64,001,811, forward strandOTUB1MACROD1: 63,998,553–64,166,501, reverse strandMACROD1FLRT1: 64,035,757–64,119,403, forward strandFLRT1Diagram of PLAAT3: 5 exons on the reverse strand of chromosome 11Exon 5: 63,574,462–63,575,046, 585 basesExon 4: 63,590,100–63,590,368, 269 basesExon 3: 63,598,061–63,598,163, 103 basesExon 2: 63,614,000–63,614,068, 69 basesExon 1: 63,614,385–63,614,433, 49 bases515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.1 kb of the gene's 40 kb; 489 of those bases code for the protein.

How a genome test reads PLAAT3

1

position in PLAAT3 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 40 kb of PLAAT3, introns included, not only the 1.1 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). PLAAT3 gene: phospholipase A and acyltransferase 3. Retrieved 17 October 2026, from https://dantelabs.com/genes/plaat3

Vancouver

Dante Labs. PLAAT3 gene: phospholipase A and acyltransferase 3 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/plaat3

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