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Gene

HBG1

hemoglobin subunit gamma 1

Summary

Cytogenetic location
11p15.4
Coordinates
Chromosome 11: 5,248,269–5,249,857 (GRCh38)
Exons
3 exons across 1.6 kb
Protein
147 amino acids
Inheritance
Autosomal recessive
Also known as
HBG-T2
MANE Select transcript
ENST00000330597.5NM_000559.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Thalassaemia

    • Beta-Thalassaemia and Related DisordersAutosomal recessive

      Disorders of beta-globin production, including beta-thalassaemia, haemoglobin E-beta-thalassaemia, delta-beta-thalassaemia and haemoglobin Lepore, ranging from carrier states with mild anaemia to transfusion-dependent disease.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Carrier status is relevant to family planning, and affected people may need transfusions, iron chelation or newer treatments.

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How HBG1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 11, with a bracket where HBG1 sits. HBG1 and 44 genes near it on chromosome 11, from 4,749,063 to 5,749,062.Chromosome 1111p15.4p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q254.8 Mb5 Mb5.2 Mb5.4 Mb5.6 MbMMP26: 4,704,784–4,992,431, forward strandOR51F1: 4,768,979–4,769,938, reverse strandOR51F1OR52R1: 4,803,433–4,804,380, reverse strandOR52R1OR51F2: 4,821,321–4,822,456, forward strandOR51F2OR51S1: 4,848,237–4,849,208, reverse strandOR51S1OR51T1: 4,881,819–4,882,883, forward strandOR51T1OR51A7: 4,903,783–4,909,462, forward strandOR51G2: 4,912,588–4,919,350, reverse strandOR51G2OR51G1: 4,923,374–4,924,339, reverse strandOR51G1OR51A4: 4,942,831–4,947,605, reverse strandOR51A4OR51A2: 4,954,772–4,955,713, reverse strandOR51A2OR51L1: 4,994,851–5,005,536, forward strandOR51L1OR52J3: 5,046,526–5,047,461, forward strandOR52J3OR52E2: 5,058,650–5,059,627, reverse strandOR52E2OR52E1: 5,069,572–5,070,497, forward strandOR52E1OR52A5: 5,128,776–5,138,356, reverse strandOR52A5OR52A1: 5,146,824–5,154,757, reverse strandOR52A1OR51V1: 5,199,735–5,200,682, reverse strandOR51V1HBB: 5,225,464–5,229,395, reverse strandHBBHBD: 5,232,678–5,243,698, reverse strandHBDHBG1: 5,248,269–5,249,857, reverse strandHBG1: 5,248,270–5,254,783, reverse strandHBG2: 5,253,188–5,505,605, reverse strandHBG2: 5,254,392–5,678,434, reverse strandHBE1: 5,268,345–5,505,652, reverse strandOR51B4: 5,301,014–5,301,946, reverse strandOR51B4OR51B5: 5,303,444–5,505,652, reverse strandOR51B2: 5,323,359–5,324,297, reverse strandOR51B2OR51B6: 5,351,508–5,352,446, forward strandOR51B6OR51M1: 5,383,812–5,393,263, forward strandOR51M1OR51Q1: 5,422,111–5,423,206, forward strandOR51I1: 5,440,570–5,441,514, reverse strandOR51I2: 5,449,323–5,456,518, forward strandOR52D1: 5,488,685–5,489,749, forward strandUBQLN3: 5,507,300–5,509,958, reverse strandUBQLNL: 5,514,393–5,518,431, reverse strandOR52H1: 5,544,489–5,548,540, reverse strandOR52H1OR52B6: 5,580,877–5,581,884, forward strandOR52B6TRIM6: 5,596,109–5,612,958, forward strandTRIM6TRIM6-TRIM34: 5,596,725–5,644,398, forward strandTRIM6-TRIM34TRIM34: 5,619,764–5,644,398, forward strandTRIM5: 5,663,195–5,938,619, reverse strandTRIM22: 5,689,610–5,737,089, forward strandTRIM22OR52P1: 5,726,502–5,727,464, forward strandOR52P1OR56B1: 5,736,448–5,738,523, forward strandOR56B1Diagram of HBG1: 3 exons on the reverse strand of chromosome 11Exon 3: 5,248,269–5,248,487, 219 basesExon 2: 5,249,368–5,249,590, 223 basesExon 1: 5,249,713–5,249,857, 145 bases3215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 0.6 kb of the gene's 1.6 kb; 444 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). HBG1 gene: hemoglobin subunit gamma 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/hbg1

Vancouver

Dante Labs. HBG1 gene: hemoglobin subunit gamma 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/hbg1

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