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Gene

STING1

stimulator of interferon response cGAMP interactor 1

Summary

Cytogenetic location
5q31.2
Coordinates
Chromosome 5: 139,475,533–139,482,758 (GRCh38)
Exons
8 exons across 7.2 kb
Protein
379 amino acids
Inheritance
Autosomal dominant
Also known as
FLJ38577, NET23, ERIS, MPYS, STING, MITA
Previous symbols
TMEM173
MANE Select transcript
ENST00000330794.9NM_198282.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Rare Monogenic Autoinflammatory Diseases

    • PTPN2-related autoinflammation and autoimmunityAutosomal dominant

      Early-onset inflammatory and autoimmune disease, including colitis and arthritis, caused by variants in PTPN2.

      • 3 GenCC submitters rate it definitive or strong

  • Type I Interferonopathies

    • STING-associated vasculopathy with onset in infancy (SAVI)Autosomal dominant

      Inflammation of small blood vessels and the lungs starting in infancy, caused by gain-of-function variants in STING1; JAK inhibitors are used in treatment.

      • 3 GenCC submitters rate it definitive or strong

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How STING1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 5, with a bracket where STING1 sits. STING1 and 15 genes near it on chromosome 5, from 138,979,146 to 139,979,145.Chromosome 55q31.2p15.33p15.32p15.31p15.2p15.1p14.3p14.2p14.1p13.3p13.2p13.1p12p11q11.1q11.2q12.1q12.2q12.3q13.1q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q31.1q31.2q31.3q32q33.1q33.2q33.3q34q35.1q35.2q35.3139 Mb139.2 Mb139.4 Mb139.6 Mb139.8 MbSIL1: 138,886,914–139,293,557, reverse strandSIL1MATR3: 139,273,752–139,332,518, forward strandMATR3PAIP2: 139,341,587–139,369,733, forward strandSLC23A1: 139,366,642–139,385,495, reverse strandMZB1: 139,387,467–139,390,081, reverse strandMZB1PROB1: 139,390,592–139,395,104, reverse strandPROB1SPATA24: 139,396,563–139,404,094, reverse strandSPATA24DNAJC18: 139,408,588–139,444,491, reverse strand: 139,442,316–139,462,707, reverse strandECSCR: 139,446,541–139,462,751, reverse strandECSCRSMIM33: 139,471,004–139,474,650, forward strandSMIM33STING1: 139,475,533–139,482,758, reverse strandSTING1UBE2D2: 139,526,431–139,633,291, forward strandUBE2D2CXXC5: 139,646,375–139,683,882, forward strandCXXC5PSD2: 139,795,606–139,844,470, forward strandPSD2NRG2: 139,846,779–140,043,328, reverse strandNRG2Diagram of STING1: 8 exons on the reverse strand of chromosome 5Exon 8: 1 known disease-causing siteExon 7: 3 known disease-causing sitesExon 6: 2 known disease-causing sitesExon 5: 4 known disease-causing sitesExon 8: 139,475,533–139,476,454, 922 basesExon 7: 139,477,329–139,477,515, 187 basesExon 6: 139,478,270–139,478,508, 239 basesExon 5: 139,480,790–139,480,898, 109 basesExon 4: 139,481,159–139,481,342, 184 basesExon 3: 139,481,478–139,481,704, 227 basesExon 2: 139,482,210–139,482,302, 93 basesExon 1: 139,482,550–139,482,758, 209 bases876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.2 kb of the gene's 7.2 kb; 1,140 of those bases code for the protein.

How a genome test reads STING1

10

positions in STING1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 7.2 kb of STING1, introns included, not only the 2.2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). STING1 gene: stimulator of interferon response cGAMP interactor 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/sting1

Vancouver

Dante Labs. STING1 gene: stimulator of interferon response cGAMP interactor 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/sting1

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