Trăsături

Trăsături asociate cu TREM2

triggering receptor expressed on myeloid cells 2

Human Phenotype Ontology asociază 157 trăsături cu TREM2, grupate pe sisteme ale organismului: trăsături observate la persoanele cu una dintre afecțiunile rare ale genei.

TREM2

Abnormality of the nervous system

Trăsătură	Cât de frecvent apare
Decrease in size of the outer layer of the brain due to loss of brain cells	Întotdeauna
Dementia	Întotdeauna
Lateral ventricle dilatation	Întotdeauna
Leukoencephalopathy	Întotdeauna
Lou Gehrig's disease	Întotdeauna
Abnormal social behavior	Foarte des (80–99%)
Aggressive behavior	Foarte des (80–99%)
Agitation	Foarte des (80–99%)
Behavioral abnormality	Foarte des (80–99%)
Brain degeneration	Foarte des (80–99%)
Confusion	Foarte des (80–99%)
Difficulty finding words	Foarte des (80–99%)
Difficulty making arithmetical calculations	Foarte des (80–99%)
Disinhibition	Foarte des (80–99%)
Dysgraphia	Foarte des (80–99%)
Echoing another person's speech	Foarte des (80–99%)
Emotional poverty	Foarte des (80–99%)
Epilepsy	Foarte des (80–99%)
Frontal lobe dementia	Foarte des (80–99%)
Frontotemporal cerebral atrophy	Foarte des (80–99%)
Frontotemporal dementia	Foarte des (80–99%)
Grammar-specific speech disorder	Foarte des (80–99%)
Hallucinations	Foarte des (80–99%)
Hyperorality	Foarte des (80–99%)
Inappropriate behavior	Foarte des (80–99%)
Irritability	Foarte des (80–99%)
Jerking	Foarte des (80–99%)
Lack of insight	Foarte des (80–99%)
Language impairment	Foarte des (80–99%)
Loss of developmental milestones	Foarte des (80–99%)
Loss of speech	Foarte des (80–99%)
Memory impairment	Foarte des (80–99%)
Mental deterioration	Foarte des (80–99%)
Motor neuron atrophy	Foarte des (80–99%)
Neurodevelopmental abnormality	Foarte des (80–99%)
Neurofibrillary tangles	Foarte des (80–99%)
Ongoing loss of nerve cells	Foarte des (80–99%)
Parkinsonism	Foarte des (80–99%)
Perseverative thought	Foarte des (80–99%)
Personality changes	Foarte des (80–99%)
Poor speech	Foarte des (80–99%)
Reading disability	Foarte des (80–99%)
Repetitive movements	Foarte des (80–99%)
Restlessness	Foarte des (80–99%)
Restrictive behavior	Foarte des (80–99%)
Spoken word recognition deficit	Foarte des (80–99%)
Temporal cortical atrophy	Foarte des (80–99%)
Underdevelopment of part of brain called corpus callosum	Foarte des (80–99%)
Ventriculomegaly	Foarte des (80–99%)
Visual agnosia	Foarte des (80–99%)
Word-finding difficulty	Foarte des (80–99%)
Abnormal brain FDG positron emission tomography	Des (30–79%)
Abnormal cerebral white matter morphology	Des (30–79%)
Abnormal speech pattern	Des (30–79%)
Abnormality of movement	Des (30–79%)
Abulia	Des (30–79%)
Anxiety	Des (30–79%)
Apraxia	Des (30–79%)
Babinski sign	Des (30–79%)
Can't control feelings	Des (30–79%)
Caudate atrophy	Des (30–79%)
Chorea	Des (30–79%)
Cognitive impairment	Des (30–79%)
Compulsive hoarding	Des (30–79%)
Depression	Des (30–79%)
Difficulty articulating speech	Des (30–79%)
Disturbed sensory perception	Des (30–79%)
EEG with continuous slow activity	Des (30–79%)
Hoffmann sign	Des (30–79%)
Increased reflexes	Des (30–79%)
Muscle twitch	Des (30–79%)
Paralysis	Des (30–79%)
T2 hypointense thalamus	Des (30–79%)
Text blindness	Des (30–79%)
Abnormal gait	Uneori (5–29%)
Abnormal lower motor neuron morphology	Uneori (5–29%)
Abnormality of extrapyramidal motor function	Uneori (5–29%)
Abnormality of mental function	Uneori (5–29%)
Astrocytosis	Uneori (5–29%)
Ataxia	Uneori (5–29%)
Difficulty sleeping	Uneori (5–29%)
Finger agnosia	Uneori (5–29%)
Grand mal seizures	Uneori (5–29%)
High stepping	Uneori (5–29%)
Inability to speak	Uneori (5–29%)
Intellectual disability	Uneori (5–29%)
Jaw hyperreflexia	Uneori (5–29%)
Lack of feeling, emotion, interest	Uneori (5–29%)
Loss of expressive speech	Uneori (5–29%)
Psychosis	Uneori (5–29%)
Senile plaques	Uneori (5–29%)
Too much cerebrospinal fluid in the brain	Uneori (5–29%)
Trouble remembering words	Uneori (5–29%)
Upper motor neuron dysfunction	Uneori (5–29%)
Abnormal shape of upper motor neuron	Neînregistrat
Alzheimer disease	Neînregistrat
Axonal loss	Neînregistrat
Brain neoplasm	Neînregistrat
CNS demyelination	Neînregistrat
Degeneration of cerebrum	Neînregistrat
EEG abnormality	Neînregistrat
Euphoria	Neînregistrat
Gliosis	Neînregistrat
Lewy bodies	Neînregistrat
Peripheral demyelination	Neînregistrat
Primitive reflex	Neînregistrat

Abnormality of the musculoskeletal system

Trăsătură	Cât de frecvent apare
Basal ganglia calcification	Întotdeauna
Bone cyst	Întotdeauna
Abnormal shape of end part of bone	Foarte des (80–99%)
Abnormal skeletal development	Foarte des (80–99%)
Abnormality of adipose tissue	Foarte des (80–99%)
Bone pain	Foarte des (80–99%)
Deposits immunoreactive to beta-amyloid protein	Foarte des (80–99%)
Generalized muscle weakness	Foarte des (80–99%)
Limitation of joint mobility	Foarte des (80–99%)
Low solidness and mass of the bones	Foarte des (80–99%)
Spasticity and rigidity of muscles	Foarte des (80–99%)
Abnormal deposits of calcium in the brain	Des (30–79%)
Distal muscle wasting	Des (30–79%)
Fatigable weakness of bulbar muscles	Des (30–79%)
Fatigable weakness of respiratory muscles	Des (30–79%)
Fatigable weakness of swallowing muscles	Des (30–79%)
Involuntary muscle stiffness, contraction, or spasm	Des (30–79%)
Muscle degeneration	Des (30–79%)
Muscle spasm	Des (30–79%)
Progressive distal muscular atrophy	Des (30–79%)
Spastic paraparesis	Uneori (5–29%)
Osteopenia	Neînregistrat
Spontaneous fracture	Neînregistrat

Abnormality of head or neck

Trăsătură	Cât de frecvent apare
Thickened skin folds of neck	Foarte des (80–99%)
Decreased salivary flow	Des (30–79%)
Drooling	Des (30–79%)
Wasting of the tongue	Des (30–79%)
Tongue twitching	Uneori (5–29%)

Abnormality of limbs

Trăsătură	Cât de frecvent apare
Decreased arm strength	Des (30–79%)
Lower limb muscle weakness	Des (30–79%)
Foot drop	Uneori (5–29%)
Abnormal feet structure	Neînregistrat
Abnormality of the hand	Neînregistrat

Abnormality of the respiratory system

Trăsătură	Cât de frecvent apare
Abnormality on pulmonary function testing	Des (30–79%)
Breathing difficulty	Des (30–79%)
Respiratory failure	Des (30–79%)
Orthopnea	Uneori (5–29%)
Laryngospasm	Rar (1–4%)

Constitutional symptom

Trăsătură	Cât de frecvent apare
Joint pain	Foarte des (80–99%)
Fatigue	Des (30–79%)
Pain	Des (30–79%)

Abnormality of the digestive system

Trăsătură	Cât de frecvent apare
Poor swallowing	Des (30–79%)
Functional abnormality of the gastrointestinal tract	Uneori (5–29%)

Abnormality of the eye

Trăsătură	Cât de frecvent apare
Oculomotor apraxia	Des (30–79%)
Abnormality of vision	Uneori (5–29%)

Growth abnormality

Trăsătură	Cât de frecvent apare
Weight loss	Des (30–79%)
Wasting syndrome	Uneori (5–29%)

Abnormality of blood and blood-forming tissues

Trăsătură	Cât de frecvent apare
Acute blood cancer	Uneori (5–29%)

Abnormality of the cardiovascular system

Trăsătură	Cât de frecvent apare
Stroke	Neînregistrat

Abnormality of the genitourinary system

Trăsătură	Cât de frecvent apare
Loss of bladder control	Neînregistrat

Abnormality of the voice

Trăsătură	Cât de frecvent apare
Inability to produce voice sounds	Des (30–79%)

Cât de frecvent apare în rândul persoanelor cu una dintre afecțiunile asociate genei, cel mai des întâlnit dintre acestea, conform Human Phenotype Ontology. Aceste pagini descriu trăsături și cercetările din spatele lor; ele nu reprezintă un diagnostic, iar pentru simptome trebuie să vă adresați medicului sau consilierului genetic.

De unde provin aceste informații

Human Phenotype Ontology, versiunea 2026-09-01: trăsăturile asociate cu TREM2 și frecvența cu care fiecare este observată. Aflați mai multe la hpo.jax.org.

Un test. Răspunsuri pentru o viață.

De la 449 $Livrare gratuită · Rezultate în 6–8 săptămâni

Comandați Genome Test-ul meu