Traits

Traits linked to RET

ret proto-oncogene

The Human Phenotype Ontology links 139 traits to RET, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the digestive system

Trait	Cât de frecvent apare
Abdominal pain	Foarte des (80–99%)
Constipation	Foarte des (80–99%)
Enlarged colon lacking nerve cells	Foarte des (80–99%)
Functional abnormality of the gastrointestinal tract	Foarte des (80–99%)
Intestinal obstruction	Foarte des (80–99%)
Nausea and vomiting	Foarte des (80–99%)
Abdominal bloating	Des (30–79%)
Abnormal connection between trachea and esophagus	Des (30–79%)
Abnormality of the intestine	Des (30–79%)
Acid reflux	Des (30–79%)
Bilious emesis	Des (30–79%)
Feeding difficulties	Des (30–79%)
Intermittent abdominal pain	Des (30–79%)
Nausea	Des (30–79%)
Abdominal mass	Uneori (5–29%)
Colon perforation	Uneori (5–29%)
Diarrhea	Uneori (5–29%)
Enterocolitis	Uneori (5–29%)
Abnormal enteric ganglion morphology	Neînregistrat
Colonic diverticula	Neînregistrat
Vomiting	Neînregistrat

Abnormality of the cardiovascular system

Trait	Cât de frecvent apare
Abnormal cardiovascular system morphology	Des (30–79%)
Decrease in blood pressure upon standing up	Des (30–79%)
Fainting spell	Des (30–79%)
High blood pressure	Des (30–79%)
Hypertension associated with pheochromocytoma	Des (30–79%)
Hypertensive crisis	Des (30–79%)
Hypertensive retinopathy	Des (30–79%)
Palpitations	Des (30–79%)
Positive regitine blocking test	Des (30–79%)
Sinus tachycardia	Des (30–79%)
Arachnoid hemangiomatosis	Uneori (5–29%)
Cardiac failure	Uneori (5–29%)
Disease of the heart muscle	Uneori (5–29%)
Inflammation of heart muscle	Uneori (5–29%)
Elevated heart rate	Neînregistrat
Intermittent high blood pressure	Neînregistrat
Narrowing of kidney artery	Neînregistrat
Strawberry mark	Neînregistrat

Abnormality of the nervous system

Trait	Cât de frecvent apare
Abnormal autonomic nervous system physiology	Foarte des (80–99%)
Central sleep apnea	Foarte des (80–99%)
Epilepsy	Des (30–79%)
Episodic paroxysmal anxiety	Des (30–79%)
Intellectual disability	Des (30–79%)
Recurrent paroxysmal headache	Des (30–79%)
Cancer of early nerve cells	Uneori (5–29%)
Cranial nerve compression	Uneori (5–29%)
Ganglioneuroma	Uneori (5–29%)
Headache	Uneori (5–29%)
Inability to move vocal cords	Uneori (5–29%)
Panic attack	Uneori (5–29%)
Tremor	Uneori (5–29%)
Global developmental delay	Neînregistrat

Abnormality of the endocrine system

Trait	Cât de frecvent apare
Thyroid nodule	Întotdeauna
Adrenal pheochromocytoma	Foarte des (80–99%)
Elevated blood parathyroid hormone level	Foarte des (80–99%)
Extraadrenal pheochromocytoma	Foarte des (80–99%)
Paraganglioma	Foarte des (80–99%)
Medullary thyroid carcinoma	Des (30–79%)
Paraganglioma of head and neck	Des (30–79%)
Pheochromocytoma	Des (30–79%)
Enlarged parathyroid glands	Neînregistrat
Increased circulating cortisol level	Neînregistrat
Nodular goiter	Neînregistrat
Parathyroid adenoma	Neînregistrat
Thyroid C cell hyperplasia	Neînregistrat

Laboratory abnormality

Trait	Cât de frecvent apare
Elevated calcitonin	Întotdeauna
Nonketotic hypoglycemia	Foarte des (80–99%)
Elevated urinary dopamine	Des (30–79%)
Elevated urinary epinephrine level	Des (30–79%)
Elevated urinary norepinephrine level	Des (30–79%)
Elevated urinary vanillylmandelic acid	Des (30–79%)
High blood calcium levels	Des (30–79%)
High urine protein levels	Des (30–79%)
Blood in urine	Uneori (5–29%)
High blood sugar	Uneori (5–29%)
Cutaneous lichen amyloidosis	Neînregistrat

Abnormality of head or neck

Trait	Cât de frecvent apare
Eye folds	Foarte des (80–99%)
Flat nose	Foarte des (80–99%)
Cleft palate	Uneori (5–29%)
Non-midline cleft of the upper lip	Uneori (5–29%)
Retinal capillary hemangioma	Uneori (5–29%)
Full lower lip	Neînregistrat
High palate	Neînregistrat
High, narrow palate	Neînregistrat
Thick eyebrow	Neînregistrat

Abnormality of the musculoskeletal system

Trait	Cât de frecvent apare
Abnormal sacrum morphology	Des (30–79%)
Low muscle tone	Des (30–79%)
Double-Jointed	Neînregistrat
Funnel chest	Neînregistrat
Generalized decreased muscle tone	Neînregistrat
Hunched back	Neînregistrat
Muscle tissue disease	Neînregistrat
Prominent swayback	Neînregistrat
Scoliosis	Neînregistrat

Growth abnormality

Trait	Cât de frecvent apare
Faltering weight	Foarte des (80–99%)
Small for gestational age	Foarte des (80–99%)
Weight loss	Des (30–79%)
Faltering weight in infancy	Uneori (5–29%)
Growth delay	Uneori (5–29%)
Short stature	Uneori (5–29%)
Disproportionate tall stature	Neînregistrat

Abnormality of the genitourinary system

Trait	Cât de frecvent apare
Absent kidney	Foarte des (80–99%)
Glomerular sclerosis	Des (30–79%)
Urogenital fistula	Des (30–79%)
Abnormal morphology of female internal genitalia	Uneori (5–29%)
Cancer starting in small tubes in kidneys	Uneori (5–29%)
Renal failure	Uneori (5–29%)

Abnormality of prenatal development or birth

Trait	Cât de frecvent apare
Low levels of amniotic fluid	Foarte des (80–99%)
Delayed passage of meconium	Des (30–79%)
Fetal polyuria	Des (30–79%)
High levels of amniotic fluid	Uneori (5–29%)
Less than 10 fetal movements in 12 hours	Uneori (5–29%)

Abnormality of the ear

Trait	Cât de frecvent apare
Low-set ears	Foarte des (80–99%)
Paroxysmal vertigo	Des (30–79%)
Pulsatile tinnitus	Des (30–79%)
Conductive deafness	Uneori (5–29%)
Sensorineural hearing impairment	Uneori (5–29%)

Abnormality of the integument

Trait	Cât de frecvent apare
Flushing	Des (30–79%)
Sporadic excessive sweating	Des (30–79%)
Paleness	Uneori (5–29%)
Birthmark	Neînregistrat
Excessive sweating	Neînregistrat

Abnormality of the eye

Trait	Cât de frecvent apare
Cross-eyed	Foarte des (80–99%)
Wide-set eyes	Foarte des (80–99%)
Absent iris	Rar (1–4%)
Clouding of the lens of the eye at birth	Neînregistrat

Abnormality of limbs

Trait	Cât de frecvent apare
Sirenomelia	Uneori (5–29%)
High-arched foot	Neînregistrat
Slipped end part of innermost thighbone	Neînregistrat

Abnormality of the respiratory system

Trait	Cât de frecvent apare
Breathing dysregulation	Foarte des (80–99%)
Central hypoventilation	Foarte des (80–99%)
Poorly developed lungs	Foarte des (80–99%)

Constitutional symptom

Trait	Cât de frecvent apare
Chest pain	Des (30–79%)
Fatigue	Des (30–79%)

Abnormal tissue mass

Trait	Cât de frecvent apare
Abnormal tissue mass	Neînregistrat

Abnormality of blood and blood-forming tissues

Trait	Cât de frecvent apare
Bleeding in brain	Des (30–79%)

Abnormality of the immune system

Trait	Cât de frecvent apare
Infection in blood stream	Uneori (5–29%)

Abnormality of the voice

Trait	Cât de frecvent apare
Inability to produce voice sounds	Des (30–79%)

Cât de frecvent apare în rândul persoanelor cu una dintre afecțiunile asociate genei, cel mai des întâlnit dintre acestea, conform Human Phenotype Ontology. Aceste pagini descriu trăsături și cercetările din spatele lor; ele nu reprezintă un diagnostic, iar pentru simptome trebuie să vă adresați medicului sau consilierului genetic.

De unde provin aceste informații

The Human Phenotype Ontology, release 2026-09-01: the traits linked to RET and how often each is seen. Find out more at hpo.jax.org.

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