Traits

Traits linked to MEN1

menin 1

The Human Phenotype Ontology links 175 traits to MEN1, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the endocrine system

Trait	Cât de frecvent apare
Abnormal pituitary gland morphology	Foarte des (80–99%)
Decreased activity of gonads	Foarte des (80–99%)
Decreased function of male gonad	Foarte des (80–99%)
Enlarged parathyroid glands	Foarte des (80–99%)
Female hypogonadism	Foarte des (80–99%)
Growth hormone excess	Foarte des (80–99%)
Hypogonadotropic hypogonadism	Foarte des (80–99%)
Increased circulating insulin-like growth factor 1 concentration	Foarte des (80–99%)
Parathyroid adenoma	Foarte des (80–99%)
Pituitary growth hormone cell adenoma	Foarte des (80–99%)
Premature pubic hair growth	Foarte des (80–99%)
Primary hyperparathyroidism	Foarte des (80–99%)
Adrenocortical abnormality	Des (30–79%)
Adrenocorticotropic hormone deficiency	Des (30–79%)
Adrenocorticotropin deficient adrenal insufficiency	Des (30–79%)
Central adrenal insufficiency	Des (30–79%)
Decreased circulating ACTH concentration	Des (30–79%)
Elevated gastrin in the blood	Des (30–79%)
Increased circulating prolactin concentration	Des (30–79%)
Low thyroid gland function due to abnormal pituitary gland	Des (30–79%)
Noncancerous tumor in pituitary gland	Des (30–79%)
Pituitary prolactin cell adenoma	Des (30–79%)
Secondary growth hormone deficiency	Des (30–79%)
Abnormal circulating aldosterone	Uneori (5–29%)
Adrenocortical adenoma	Uneori (5–29%)
Adrenocortical carcinoma	Uneori (5–29%)
Anterior hypopituitarism	Uneori (5–29%)
Carcinoid tumor	Uneori (5–29%)
Delayed puberty	Uneori (5–29%)
Enlarged thyroid gland in neck	Uneori (5–29%)
Increased circulating cortisol level	Uneori (5–29%)
Neoplasm of the adrenal gland	Uneori (5–29%)
Neuroendocrine neoplasm	Uneori (5–29%)
Pancreatic endocrine tumor	Uneori (5–29%)
Primary hypercortisolism	Uneori (5–29%)
Thyroid carcinoma	Uneori (5–29%)
Glucagonoma	Rar (1–4%)
Increased serum serotonin	Rar (1–4%)
Parathyroid carcinoma	Rar (1–4%)
Pheochromocytoma	Rar (1–4%)
Pituitary corticotropic cell adenoma	Rar (1–4%)
Pituitary gonadotropic cell adenoma	Rar (1–4%)
Pituitary null cell adenoma	Rar (1–4%)
Pituitary thyrotropic cell adenoma	Rar (1–4%)
Pulmonary carcinoid tumor	Rar (1–4%)
Thyroid adenoma	Neînregistrat

Abnormality of the nervous system

Trait	Cât de frecvent apare
Epilepsy	Foarte des (80–99%)
Transient global amnesia	Foarte des (80–99%)
Tremor	Foarte des (80–99%)
Behavioral abnormality	Des (30–79%)
Disturbances of consciousness	Des (30–79%)
Fluctuations in consciousness	Des (30–79%)
Headache	Des (30–79%)
Increased appetite	Des (30–79%)
Abducens palsy	Uneori (5–29%)
Abnormal rapid eye movement sleep	Uneori (5–29%)
Abnormality of mental function	Uneori (5–29%)
Abnormality of pain sensation	Uneori (5–29%)
Anxiety	Uneori (5–29%)
Coma	Uneori (5–29%)
Confusion	Uneori (5–29%)
Cranial nerve compression	Uneori (5–29%)
Cranial nerve paralysis	Uneori (5–29%)
Decreased vigilance	Uneori (5–29%)
Depression	Uneori (5–29%)
Difficulty staying or falling asleep	Uneori (5–29%)
Fourth cranial nerve palsy	Uneori (5–29%)
Lethargy	Uneori (5–29%)
Noncancerous growth of membranes covering brain	Uneori (5–29%)
Pins and needles feeling	Uneori (5–29%)
Short attention span	Uneori (5–29%)
Atypical absence status epilepticus	Rar (1–4%)
Ependymoma	Rar (1–4%)

Abnormality of the digestive system

Trait	Cât de frecvent apare
Abnormality of the pancreatic islet cells	Foarte des (80–99%)
Abdominal pain	Des (30–79%)
Acid reflux	Des (30–79%)
Cancer of the pancreas	Des (30–79%)
Diarrhea	Des (30–79%)
Nausea and vomiting	Des (30–79%)
Sore in the lining of gastrointestinal tract	Des (30–79%)
Vomiting	Des (30–79%)
Zollinger-Ellison syndrome	Des (30–79%)
Abdominal symptom	Uneori (5–29%)
Anorexia	Uneori (5–29%)
Constipation	Uneori (5–29%)
Duodenal ulcer	Uneori (5–29%)
Insulinoma	Uneori (5–29%)
Intestinal carcinoid	Uneori (5–29%)
Nausea	Uneori (5–29%)
Inflammation of the esophagus	Neînregistrat
Pancreatic islet cell adenoma	Neînregistrat

Laboratory abnormality

Trait	Cât de frecvent apare
Elevated circulating parathyroid hormone level	Foarte des (80–99%)
Elevated urine calcium levels	Foarte des (80–99%)
High blood calcium levels	Foarte des (80–99%)
High blood insulin levels while fasting	Foarte des (80–99%)
High urine phosphate levels	Foarte des (80–99%)
Hyperinsulinemia	Foarte des (80–99%)
Hyperinsulinemic hypoglycemia	Foarte des (80–99%)
Low blood phosphate level	Foarte des (80–99%)
Noninsulin-dependent diabetes	Foarte des (80–99%)
Nonketotic hypoglycemia	Foarte des (80–99%)
Recurrent low blood sugar levels	Foarte des (80–99%)
Low blood sugar after a meal	Des (30–79%)
Dehydration	Uneori (5–29%)
Elevated calcitonin	Rar (1–4%)
Low blood sugar	Neînregistrat

Abnormality of the genitourinary system

Trait	Cât de frecvent apare
Abnormal absence of menstruation	Foarte des (80–99%)
Abnormal erection	Foarte des (80–99%)
Abnormality of the menstrual cycle	Foarte des (80–99%)
Decreased female sex drive	Foarte des (80–99%)
Decreased fertility in females	Foarte des (80–99%)
Decreased fertility in males	Foarte des (80–99%)
Difficulty getting a full erection	Foarte des (80–99%)
Increased calcium level in kidney	Foarte des (80–99%)
Menstrual irregularity	Foarte des (80–99%)
Decreased male libido	Des (30–79%)
Dyspareunia	Des (30–79%)
Kidney stone	Uneori (5–29%)
Renal failure	Uneori (5–29%)

Abnormality of the eye

Trait	Cât de frecvent apare
Progressive loss of vision	Des (30–79%)
Abnormality of vision	Uneori (5–29%)
Bitemporal hemianopia	Uneori (5–29%)
Blindness	Uneori (5–29%)
Double vision	Uneori (5–29%)
Drooping upper eyelid	Uneori (5–29%)
Hemianopia	Uneori (5–29%)
Heteronymous hemianopia	Uneori (5–29%)
Internal ophthalmoplegia	Uneori (5–29%)
Oculomotor nerve palsy	Uneori (5–29%)
Sudden decrease in vision	Uneori (5–29%)

Abnormality of the musculoskeletal system

Trait	Cât de frecvent apare
Advanced bone age	Foarte des (80–99%)
Calcium deposits in joints	Foarte des (80–99%)
Generalized osteoporosis	Foarte des (80–99%)
Osteopenia	Foarte des (80–99%)
Generalized muscle weakness	Des (30–79%)
Low solidness and mass of the bones	Des (30–79%)
Multiple fatty lumps	Des (30–79%)
Osteoporosis	Des (30–79%)
Tired easily	Des (30–79%)
Breakdown of bone	Uneori (5–29%)
Increased susceptibility to fractures	Uneori (5–29%)

Abnormality of the cardiovascular system

Trait	Cât de frecvent apare
Enlarged and thickened heart muscle	Foarte des (80–99%)
Left ventricular hypertrophy	Foarte des (80–99%)
Palpitations	Foarte des (80–99%)
Low blood pressure	Des (30–79%)
High blood pressure	Uneori (5–29%)
Shortened QT interval	Uneori (5–29%)
Thymoma	Rar (1–4%)

Abnormality of the integument

Trait	Cât de frecvent apare
Excessive sweating	Foarte des (80–99%)
Abnormal hair quantity	Des (30–79%)
Large cafe-au-lait macules with irregular margins	Des (30–79%)
Paleness	Des (30–79%)
Confetti-like hypopigmented macules	Uneori (5–29%)
Birthmark	Neînregistrat
Subcutaneous lipoma	Neînregistrat

Abnormality of head or neck

Trait	Cât de frecvent apare
Big lower jaw	Foarte des (80–99%)
Coarse facial features	Foarte des (80–99%)
Frontal bossing	Foarte des (80–99%)
Gingival fibromatosis	Uneori (5–29%)
Adenoma sebaceum	Neînregistrat

Growth abnormality

Trait	Cât de frecvent apare
Proportionate tall stature	Foarte des (80–99%)
Tall stature	Foarte des (80–99%)
Increased body weight	Des (30–79%)
Weight loss	Des (30–79%)

Abnormality of blood and blood-forming tissues

Trait	Cât de frecvent apare
Black feces	Uneori (5–29%)
Vomiting blood	Uneori (5–29%)

Abnormality of limbs

Trait	Cât de frecvent apare
Large hands	Foarte des (80–99%)
Long foot	Foarte des (80–99%)

Abnormality of the breast

Trait	Cât de frecvent apare
Spontaneous milk flow from breast	Foarte des (80–99%)
Enlarged male breast	Des (30–79%)

Abnormality of the ear

Trait	Cât de frecvent apare
Dizziness	Uneori (5–29%)
Hearing abnormality	Uneori (5–29%)

Constitutional symptom

Trait	Cât de frecvent apare
Impairment of activities of daily living	Foarte des (80–99%)
Fatigue	Des (30–79%)

Abnormal tissue mass

Trait	Cât de frecvent apare
Angiofibromas	Foarte des (80–99%)

Cât de frecvent apare în rândul persoanelor cu una dintre afecțiunile asociate genei, cel mai des întâlnit dintre acestea, conform Human Phenotype Ontology. Aceste pagini descriu trăsături și cercetările din spatele lor; ele nu reprezintă un diagnostic, iar pentru simptome trebuie să vă adresați medicului sau consilierului genetic.

De unde provin aceste informații

The Human Phenotype Ontology, release 2026-09-01: the traits linked to MEN1 and how often each is seen. Find out more at hpo.jax.org.

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