Traits

Traits linked to MEN1

menin 1

The Human Phenotype Ontology links 175 traits to MEN1, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the endocrine system

Trait	Hvor ofte den forekommer
Abnormal pituitary gland morphology	Svært ofte (80–99 %)
Decreased activity of gonads	Svært ofte (80–99 %)
Decreased function of male gonad	Svært ofte (80–99 %)
Enlarged parathyroid glands	Svært ofte (80–99 %)
Female hypogonadism	Svært ofte (80–99 %)
Growth hormone excess	Svært ofte (80–99 %)
Hypogonadotropic hypogonadism	Svært ofte (80–99 %)
Increased circulating insulin-like growth factor 1 concentration	Svært ofte (80–99 %)
Parathyroid adenoma	Svært ofte (80–99 %)
Pituitary growth hormone cell adenoma	Svært ofte (80–99 %)
Premature pubic hair growth	Svært ofte (80–99 %)
Primary hyperparathyroidism	Svært ofte (80–99 %)
Adrenocortical abnormality	Ofte (30–79 %)
Adrenocorticotropic hormone deficiency	Ofte (30–79 %)
Adrenocorticotropin deficient adrenal insufficiency	Ofte (30–79 %)
Central adrenal insufficiency	Ofte (30–79 %)
Decreased circulating ACTH concentration	Ofte (30–79 %)
Elevated gastrin in the blood	Ofte (30–79 %)
Increased circulating prolactin concentration	Ofte (30–79 %)
Low thyroid gland function due to abnormal pituitary gland	Ofte (30–79 %)
Noncancerous tumor in pituitary gland	Ofte (30–79 %)
Pituitary prolactin cell adenoma	Ofte (30–79 %)
Secondary growth hormone deficiency	Ofte (30–79 %)
Abnormal circulating aldosterone	Noen ganger (5–29 %)
Adrenocortical adenoma	Noen ganger (5–29 %)
Adrenocortical carcinoma	Noen ganger (5–29 %)
Anterior hypopituitarism	Noen ganger (5–29 %)
Carcinoid tumor	Noen ganger (5–29 %)
Delayed puberty	Noen ganger (5–29 %)
Enlarged thyroid gland in neck	Noen ganger (5–29 %)
Increased circulating cortisol level	Noen ganger (5–29 %)
Neoplasm of the adrenal gland	Noen ganger (5–29 %)
Neuroendocrine neoplasm	Noen ganger (5–29 %)
Pancreatic endocrine tumor	Noen ganger (5–29 %)
Primary hypercortisolism	Noen ganger (5–29 %)
Thyroid carcinoma	Noen ganger (5–29 %)
Glucagonoma	Sjelden (1–4%)
Increased serum serotonin	Sjelden (1–4%)
Parathyroid carcinoma	Sjelden (1–4%)
Pheochromocytoma	Sjelden (1–4%)
Pituitary corticotropic cell adenoma	Sjelden (1–4%)
Pituitary gonadotropic cell adenoma	Sjelden (1–4%)
Pituitary null cell adenoma	Sjelden (1–4%)
Pituitary thyrotropic cell adenoma	Sjelden (1–4%)
Pulmonary carcinoid tumor	Sjelden (1–4%)
Thyroid adenoma	Ikke registrert

Abnormality of the nervous system

Trait	Hvor ofte den forekommer
Epilepsy	Svært ofte (80–99 %)
Transient global amnesia	Svært ofte (80–99 %)
Tremor	Svært ofte (80–99 %)
Behavioral abnormality	Ofte (30–79 %)
Disturbances of consciousness	Ofte (30–79 %)
Fluctuations in consciousness	Ofte (30–79 %)
Headache	Ofte (30–79 %)
Increased appetite	Ofte (30–79 %)
Abducens palsy	Noen ganger (5–29 %)
Abnormal rapid eye movement sleep	Noen ganger (5–29 %)
Abnormality of mental function	Noen ganger (5–29 %)
Abnormality of pain sensation	Noen ganger (5–29 %)
Anxiety	Noen ganger (5–29 %)
Coma	Noen ganger (5–29 %)
Confusion	Noen ganger (5–29 %)
Cranial nerve compression	Noen ganger (5–29 %)
Cranial nerve paralysis	Noen ganger (5–29 %)
Decreased vigilance	Noen ganger (5–29 %)
Depression	Noen ganger (5–29 %)
Difficulty staying or falling asleep	Noen ganger (5–29 %)
Fourth cranial nerve palsy	Noen ganger (5–29 %)
Lethargy	Noen ganger (5–29 %)
Noncancerous growth of membranes covering brain	Noen ganger (5–29 %)
Pins and needles feeling	Noen ganger (5–29 %)
Short attention span	Noen ganger (5–29 %)
Atypical absence status epilepticus	Sjelden (1–4%)
Ependymoma	Sjelden (1–4%)

Abnormality of the digestive system

Trait	Hvor ofte den forekommer
Abnormality of the pancreatic islet cells	Svært ofte (80–99 %)
Abdominal pain	Ofte (30–79 %)
Acid reflux	Ofte (30–79 %)
Cancer of the pancreas	Ofte (30–79 %)
Diarrhea	Ofte (30–79 %)
Nausea and vomiting	Ofte (30–79 %)
Sore in the lining of gastrointestinal tract	Ofte (30–79 %)
Vomiting	Ofte (30–79 %)
Zollinger-Ellison syndrome	Ofte (30–79 %)
Abdominal symptom	Noen ganger (5–29 %)
Anorexia	Noen ganger (5–29 %)
Constipation	Noen ganger (5–29 %)
Duodenal ulcer	Noen ganger (5–29 %)
Insulinoma	Noen ganger (5–29 %)
Intestinal carcinoid	Noen ganger (5–29 %)
Nausea	Noen ganger (5–29 %)
Inflammation of the esophagus	Ikke registrert
Pancreatic islet cell adenoma	Ikke registrert

Laboratory abnormality

Trait	Hvor ofte den forekommer
Elevated circulating parathyroid hormone level	Svært ofte (80–99 %)
Elevated urine calcium levels	Svært ofte (80–99 %)
High blood calcium levels	Svært ofte (80–99 %)
High blood insulin levels while fasting	Svært ofte (80–99 %)
High urine phosphate levels	Svært ofte (80–99 %)
Hyperinsulinemia	Svært ofte (80–99 %)
Hyperinsulinemic hypoglycemia	Svært ofte (80–99 %)
Low blood phosphate level	Svært ofte (80–99 %)
Noninsulin-dependent diabetes	Svært ofte (80–99 %)
Nonketotic hypoglycemia	Svært ofte (80–99 %)
Recurrent low blood sugar levels	Svært ofte (80–99 %)
Low blood sugar after a meal	Ofte (30–79 %)
Dehydration	Noen ganger (5–29 %)
Elevated calcitonin	Sjelden (1–4%)
Low blood sugar	Ikke registrert

Abnormality of the genitourinary system

Trait	Hvor ofte den forekommer
Abnormal absence of menstruation	Svært ofte (80–99 %)
Abnormal erection	Svært ofte (80–99 %)
Abnormality of the menstrual cycle	Svært ofte (80–99 %)
Decreased female sex drive	Svært ofte (80–99 %)
Decreased fertility in females	Svært ofte (80–99 %)
Decreased fertility in males	Svært ofte (80–99 %)
Difficulty getting a full erection	Svært ofte (80–99 %)
Increased calcium level in kidney	Svært ofte (80–99 %)
Menstrual irregularity	Svært ofte (80–99 %)
Decreased male libido	Ofte (30–79 %)
Dyspareunia	Ofte (30–79 %)
Kidney stone	Noen ganger (5–29 %)
Renal failure	Noen ganger (5–29 %)

Abnormality of the eye

Trait	Hvor ofte den forekommer
Progressive loss of vision	Ofte (30–79 %)
Abnormality of vision	Noen ganger (5–29 %)
Bitemporal hemianopia	Noen ganger (5–29 %)
Blindness	Noen ganger (5–29 %)
Double vision	Noen ganger (5–29 %)
Drooping upper eyelid	Noen ganger (5–29 %)
Hemianopia	Noen ganger (5–29 %)
Heteronymous hemianopia	Noen ganger (5–29 %)
Internal ophthalmoplegia	Noen ganger (5–29 %)
Oculomotor nerve palsy	Noen ganger (5–29 %)
Sudden decrease in vision	Noen ganger (5–29 %)

Abnormality of the musculoskeletal system

Trait	Hvor ofte den forekommer
Advanced bone age	Svært ofte (80–99 %)
Calcium deposits in joints	Svært ofte (80–99 %)
Generalized osteoporosis	Svært ofte (80–99 %)
Osteopenia	Svært ofte (80–99 %)
Generalized muscle weakness	Ofte (30–79 %)
Low solidness and mass of the bones	Ofte (30–79 %)
Multiple fatty lumps	Ofte (30–79 %)
Osteoporosis	Ofte (30–79 %)
Tired easily	Ofte (30–79 %)
Breakdown of bone	Noen ganger (5–29 %)
Increased susceptibility to fractures	Noen ganger (5–29 %)

Abnormality of the cardiovascular system

Trait	Hvor ofte den forekommer
Enlarged and thickened heart muscle	Svært ofte (80–99 %)
Left ventricular hypertrophy	Svært ofte (80–99 %)
Palpitations	Svært ofte (80–99 %)
Low blood pressure	Ofte (30–79 %)
High blood pressure	Noen ganger (5–29 %)
Shortened QT interval	Noen ganger (5–29 %)
Thymoma	Sjelden (1–4%)

Abnormality of the integument

Trait	Hvor ofte den forekommer
Excessive sweating	Svært ofte (80–99 %)
Abnormal hair quantity	Ofte (30–79 %)
Large cafe-au-lait macules with irregular margins	Ofte (30–79 %)
Paleness	Ofte (30–79 %)
Confetti-like hypopigmented macules	Noen ganger (5–29 %)
Birthmark	Ikke registrert
Subcutaneous lipoma	Ikke registrert

Abnormality of head or neck

Trait	Hvor ofte den forekommer
Big lower jaw	Svært ofte (80–99 %)
Coarse facial features	Svært ofte (80–99 %)
Frontal bossing	Svært ofte (80–99 %)
Gingival fibromatosis	Noen ganger (5–29 %)
Adenoma sebaceum	Ikke registrert

Growth abnormality

Trait	Hvor ofte den forekommer
Proportionate tall stature	Svært ofte (80–99 %)
Tall stature	Svært ofte (80–99 %)
Increased body weight	Ofte (30–79 %)
Weight loss	Ofte (30–79 %)

Abnormality of blood and blood-forming tissues

Trait	Hvor ofte den forekommer
Black feces	Noen ganger (5–29 %)
Vomiting blood	Noen ganger (5–29 %)

Abnormality of limbs

Trait	Hvor ofte den forekommer
Large hands	Svært ofte (80–99 %)
Long foot	Svært ofte (80–99 %)

Abnormality of the breast

Trait	Hvor ofte den forekommer
Spontaneous milk flow from breast	Svært ofte (80–99 %)
Enlarged male breast	Ofte (30–79 %)

Abnormality of the ear

Trait	Hvor ofte den forekommer
Dizziness	Noen ganger (5–29 %)
Hearing abnormality	Noen ganger (5–29 %)

Constitutional symptom

Trait	Hvor ofte den forekommer
Impairment of activities of daily living	Svært ofte (80–99 %)
Fatigue	Ofte (30–79 %)

Abnormal tissue mass

Trait	Hvor ofte den forekommer
Angiofibromas	Svært ofte (80–99 %)

Hvor ofte dette forekommer hos personer med en av genets tilstander, oppgitt som den hyppigste forekomsten blant dem, slik Human Phenotype Ontology registrerer den. Disse sidene beskriver egenskaper og forskningen bak dem. De er ikke en diagnose, og om symptomer bør du spørre lege eller genetisk rådgiver.

Slik er informasjonen samlet

The Human Phenotype Ontology, release 2026-09-01: the traits linked to MEN1 and how often each is seen. Find out more at hpo.jax.org.

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