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Gene

FGF8

fibroblast growth factor 8

Summary

Cytogenetic location
10q24.32
Coordinates
Chromosome 10: 101,770,109–101,776,114 (GRCh38)
Exons
6 exons across 6 kb
Protein
244 amino acids
Also known as
AIGF
MANE Select transcript
ENST00000320185.7NM_033163.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Hypogonadotropic Hypogonadism

    • Abnormal ovarian or testicular function due to insufficient hormonal stimulation from the hypothalamic-pituitary axis.

      • 3 GenCC submitters rate it definitive or strong

How FGF8 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 10, with a bracket where FGF8 sits. FGF8 and 15 genes near it on chromosome 10, from 101,273,112 to 102,273,111.Chromosome 1010q24.32p15.3p15.2p15.1p14p13p12.33p12.32p12.31p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.31q23.32q23.33q24.1q24.2q24.31q24.32q24.33q25.1q25.2q25.3q26.11q26.12q26.13q26.2q26.3101.4 Mb101.6 Mb101.8 Mb102 Mb102.2 MbBTRC: 101,354,030–101,557,324, forward strandBTRCDPCD: 101,570,560–101,609,667, forward strandDPCDPOLL: 101,576,051–101,588,273, reverse strandPOLLFBXW4: 101,610,663–101,695,298, reverse strandFBXW4FGF8: 101,770,109–101,776,114, reverse strandFGF8NPM3: 101,781,318–101,783,446, reverse strandNPM3OGA: 101,784,443–101,818,620, reverse strandOGAKCNIP2: 101,825,969–101,844,005, reverse strandKCNIP2ARMH3: 101,845,599–102,056,262, reverse strandARMH3HPS6: 102,065,349–102,068,036, forward strandHPS6LDB1: 102,106,489–102,120,451, reverse strandLDB1PPRC1: 102,132,994–102,150,333, forward strandPPRC1NOLC1: 102,152,170–102,163,875, forward strandNOLC1ELOVL3: 102,226,294–102,229,589, forward strandELOVL3PITX3: 102,229,754–102,241,512, reverse strandPITX3GBF1: 102,245,371–102,382,899, forward strandGBF1Diagram of FGF8: 6 exons on the reverse strand of chromosome 10Exon 6: 3 known disease-causing sitesExon 5: 3 known disease-causing sitesExon 4: 1 known disease-causing siteExon 6: 101,770,109–101,770,619, 511 basesExon 5: 101,771,463–101,771,569, 107 basesExon 4: 101,774,732–101,774,912, 181 basesExon 3: 101,775,130–101,775,216, 87 basesExon 2: 101,775,740–101,775,776, 37 basesExon 1: 101,775,869–101,776,114, 246 bases6543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.2 kb of the gene's 6 kb; 735 of those bases code for the protein.

How a genome test reads FGF8

9

positions in FGF8 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 6 kb of FGF8, introns included, not only the 1.2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). FGF8 gene: fibroblast growth factor 8. Retrieved 17 October 2026, from https://dantelabs.com/genes/fgf8

Vancouver

Dante Labs. FGF8 gene: fibroblast growth factor 8 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/fgf8

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