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Gene

DLL1

delta like canonical Notch ligand 1

Summary

Cytogenetic location
6q27
Coordinates
Chromosome 6: 170,282,206–170,291,078 (GRCh38)
Exons
11 exons across 8.9 kb
Protein
723 amino acids
MANE Select transcript
ENST00000366756.4NM_005618.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads DLL1 yet. The test sequences your whole genome, so your data includes it all the same.

How DLL1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 6, with a bracket where DLL1 sits. DLL1 and 4 genes near it on chromosome 6, from 169,786,642 to 170,786,641.Chromosome 66q27p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q27169.8 Mb170 Mb170.2 Mb170.4 Mb170.6 MbDLL1: 170,282,206–170,291,078, reverse strandDLL1FAM120B: 170,290,703–170,407,090, forward strandFAM120BPSMB1: 170,428,569–170,553,327, reverse strandPSMB1TBP: 170,554,266–170,577,194, forward strandTBPPDCD2: 170,572,301–170,584,692, reverse strandPDCD2Diagram of DLL1: 11 exons on the reverse strand of chromosome 6Exon 9: 11 known disease-causing sitesExon 8: 2 known disease-causing sitesExon 7: 2 known disease-causing sitesExon 6: 3 known disease-causing sitesExon 4: 4 known disease-causing sitesExon 2: 8 known disease-causing sitesExon 1: 1 known disease-causing siteExon 11: 170,282,206–170,282,879, 674 basesExon 10: 170,282,988–170,283,105, 118 basesExon 9: 170,283,231–170,284,029, 799 basesExon 8: 170,284,919–170,285,135, 217 basesExon 7: 170,285,254–170,285,423, 170 basesExon 6: 170,285,569–170,285,699, 131 basesExon 5: 170,286,238–170,286,298, 61 basesExon 4: 170,288,239–170,288,496, 258 basesExon 3: 170,288,729–170,288,789, 61 basesExon 2: 170,289,512–170,289,808, 297 basesExon 1: 170,290,086–170,291,078, 993 bases11109876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.8 kb of the gene's 8.9 kb; 2,172 of those bases code for the protein.

How a genome test reads DLL1

35

positions in DLL1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 8.9 kb of DLL1, introns included, not only the 3.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). DLL1 gene: delta like canonical Notch ligand 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/dll1

Vancouver

Dante Labs. DLL1 gene: delta like canonical Notch ligand 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/dll1

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