Gene
FOXH1
forkhead box H1
- HGNC 3814↗(opens in a new tab)
- Ensembl gene ENSG00000160973↗(opens in a new tab)
- NCBI Gene 8928↗(opens in a new tab)
Summary
- Cytogenetic location
- 8q24.3
- Coordinates
- Chromosome 8: 144,473,412–144,475,849 (GRCh38)
- Exons
- 3 exons across 2.4 kb
- Protein
- 365 amino acids
- Also known as
- FAST1
- MANE Select transcript
- ENST00000377317.5NM_003923.3
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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How FOXH1 is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 2 kb of the gene's 2.4 kb; 1,098 of those bases code for the protein.
Traits linked to FOXH1
The Human Phenotype Ontology lists these as features of the rare conditions FOXH1 can cause. Each trait's page lists the other genes linked to it.
Abnormality of the nervous system
- Abnormal central motor function
- Abnormal corpus callosum morphology
- Abnormal morphology of the olfactory bulb
- Abnormal shape of brainstem
- Abnormal shape of midbrain
- Abnormality of the autonomic nervous system
- Absent speech development
- Anxiety
Show 27 more traits
- Aplasia of the falx cerebri
- Attention deficit
- Behavioral abnormality
- Communication delay
- Depression
- Epilepsy
- Impulsivity
- Inability to walk
- Intellectual disability
- Irritability
- Lack of feeling, emotion, interest
- Lethargy
- Limb dystonia
- Neural tube defect
- Oromotor apraxia
- Poor speech
- Short attention span
- Sleep-wake cycle disturbance
- Specific learning disability
- Abnormal septum pellucidum morphology
- Agenesis of corpus callosum
- Enlarged brain
- Holoprosencephaly
- Hypoplasia of the pons
- Perisylvian polymicrogyria
- Rhombencephalosynapsis
- Too much cerebrospinal fluid in the brain
Abnormality of the digestive system
- Feeding difficulties
- Poor suck
- Acid reflux
- Constipation
- Poor swallowing
- Vomiting
- Abnormal shape of the digestive system
- Absence or narrowing of first part of small bowel
Show 2 more traits
Abnormality of the endocrine system
- Abnormal hypothalamus physiology
- Abnormality of the endocrine system
- Anterior hypopituitarism
- Central diabetes insipidus
- Diabetes insipidus
- Early onset of puberty
- Central hypothyroidism
- Decreased response to growth hormone stimulation test
Show 2 more traits
Abnormality of the musculoskeletal system
- Abnormal vertebral morphology
- Abnormality of the ribs
- Decreased muscle tone in infant
- Generalized decreased muscle tone
- Involuntary muscle stiffness, contraction, or spasm
- Abnormality of the skeletal system
- EMG: myopathic abnormalities
- Flexed joint that cannot be straightened
Show 2 more traits
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
Cite this page
Dante Labs. (n.d.). FOXH1 gene: forkhead box H1. Retrieved 17 October 2026, from https://dantelabs.com/genes/foxh1
Dante Labs. FOXH1 gene: forkhead box H1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/foxh1
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