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Gene

SLC39A14

solute carrier family 39 member 14

Summary

Cytogenetic location
8p21.3
Coordinates
Chromosome 8: 22,367,278–22,422,736 (GRCh38)
Exons
9 exons across 55.5 kb
Protein
492 amino acids
Inheritance
Autosomal recessive
Also known as
KIAA0062, NET34, ZIP14, ZIP-14
MANE Select transcript
ENST00000381237.6NM_001128431.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Hereditary Manganese Transporter Disorders

    • Hypermanganesemia with DystoniaAutosomal recessive

      Accumulation of manganese in the brain and other organs caused by variants in SLC30A10 or SLC39A14, leading to progressive dystonia and parkinsonism and, with SLC30A10, liver disease and polycythaemia.

      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Knowing allows early treatment with chelation therapy and iron supplementation, which can lower manganese levels and may improve or stabilise symptoms.

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How SLC39A14 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 8, with a bracket where SLC39A14 sits. SLC39A14 and 25 genes near it on chromosome 8, from 21,895,007 to 22,895,006.Chromosome 88p21.3p23.3p23.2p23.1p22p21.3p21.2p21.1p12p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q12.1q12.2q12.3q13.1q13.2q13.3q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.322 Mb22.2 Mb22.4 Mb22.6 Mb22.8 MbDOK2: 21,907,461–21,913,960, reverse strandDOK2XPO7: 21,919,545–22,006,585, forward strandXPO7NPM2: 22,024,081–22,036,897, forward strandNPM2FGF17: 22,042,388–22,048,809, forward strandFGF17DMTN: 22,048,995–22,082,527, forward strandDMTNFHIP2B: 22,089,139–22,104,911, forward strandFHIP2BNUDT18: 22,101,008–22,109,444, reverse strandHR: 22,114,042–22,133,393, reverse strandHRURF: 22,130,458–22,131,010, reverse strandHRURFREEP4: 22,138,007–22,141,951, reverse strandREEP4LGI3: 22,146,824–22,157,084, reverse strandLGI3SFTPC: 22,156,913–22,164,479, forward strandSFTPCBMP1: 22,164,899–22,212,326, forward strandBMP1PHYHIP: 22,219,703–22,232,376, reverse strandPHYHIPPOLR3D: 22,245,078–22,254,601, forward strandPOLR3DPIWIL2: 22,275,310–22,358,580, forward strandPIWIL2SLC39A14: 22,367,278–22,422,736, forward strandSLC39A14PPP3CC: 22,440,746–22,544,727, forward strandPPP3CCSORBS3: 22,544,986–22,575,788, forward strandSORBS3PDLIM2: 22,578,058–22,598,025, forward strandPDLIM2: 22,589,274–22,602,084, forward strandC8orf58: 22,599,588–22,604,271, forward strandC8orf58CCAR2: 22,604,629–22,620,964, forward strandBIN3: 22,610,290–22,669,148, reverse strandEGR3: 22,687,659–22,693,480, reverse strandEGR3PEBP4: 22,710,102–23,000,000, reverse strandPEBP4Diagram of SLC39A14: 9 exons on the forward strand of chromosome 8Exon 2: 2 known disease-causing sitesExon 7: 1 known disease-causing siteExon 1: 22,367,278–22,367,408, 131 basesExon 2: 22,404,696–22,404,980, 285 basesExon 3: 22,408,310–22,408,496, 187 basesExon 4: 22,412,037–22,412,206, 170 basesExon 5: 22,414,780–22,414,902, 123 basesExon 6: 22,415,769–22,415,957, 189 basesExon 7: 22,416,073–22,416,280, 208 basesExon 8: 22,417,651–22,417,835, 185 basesExon 9: 22,419,552–22,422,736, 3,185 bases1246895′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.7 kb of the gene's 55.5 kb; 1,479 of those bases code for the protein.

How a genome test reads SLC39A14

6

positions in SLC39A14 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 55.5 kb of SLC39A14, introns included, not only the 4.7 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). SLC39A14 gene: solute carrier family 39 member 14. Retrieved 17 October 2026, from https://dantelabs.com/genes/slc39a14

Vancouver

Dante Labs. SLC39A14 gene: solute carrier family 39 member 14 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/slc39a14

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