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Gene

ALG9

ALG9 alpha-1,2-mannosyltransferase

Summary

Cytogenetic location
11q23.1
Coordinates
Chromosome 11: 111,782,195–111,871,581 (GRCh38)
Exons
15 exons across 89.4 kb
Protein
618 amino acids
Previous symbols
DIBD1
MANE Select transcript
ENST00000616540.5NM_024740.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Polycystic Kidney Disease

    • A usually autosomal dominant and less frequently autosomal recessive genetic disorder characterized by the presence of numerous cysts in the kidneys leading to end-stage renal failure. The autosomal dominant trait is associated with abnormalities on the short arm of chromosome 16. Symptoms in patients with the autosomal dominant trait usually appear at middle age and include abdominal pain, hematuria, and high blood pressure. Patients may develop brain aneurysms and liver cysts. Patients with the autosomal recessive trait present with progressive renal failure early in life and symptoms resulting from hepatic fibrosis. The autosomal recessive trait is associated with abnormalities of chromosome 6. Polycystic kidney disease may also result as a side effect in patients on renal dialysis.

      • ClinGen rates the link definitive
      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      Tolvaptan (Jynarque, FDA 2018) for rapidly progressive ADPKD; blood pressure control (target <110/75); pain management; cyst infection treatment; brain MRA screening for intracranial aneurysms; kidney transplantation for ESRD

Broader groupings

  • Congenital Disorders of Glycosylation

    • Congenital Disorders of Glycosylation (CDG)

      One of 98 genes linked to it

      A large group of inherited conditions in which sugar chains (glycans) are not correctly built or attached to proteins and lipids, often affecting the brain, liver, blood clotting, growth and many other body systems. Most are autosomal recessive, but some are X-linked or autosomal dominant.

      • 3 GenCC submitters rate it definitive or strong

How ALG9 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 11, with a bracket where ALG9 sits. ALG9 and 25 genes near it on chromosome 11, from 111,326,888 to 112,326,887.Chromosome 1111q23.1p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q25111.4 Mb111.6 Mb111.8 Mb112 Mb112.2 MbPOU2AF1: 111,352,255–111,455,630, reverse strandPOU2AF1BTG4: 111,467,526–111,514,367, reverse strandBTG4HOATZ: 111,514,763–111,537,043, forward strandHOATZLAYN: 111,540,280–111,565,625, forward strandLAYNSIK2: 111,602,383–111,730,855, forward strandSIK2PPP2R1B: 111,726,908–111,766,713, reverse strandPPP2R1BALG9: 111,782,195–111,871,581, reverse strandALG9: 111,786,286–111,879,425, reverse strandFDXACB1: 111,873,947–111,881,243, reverse strandFDXACB1CFAP68: 111,878,935–111,885,975, forward strandCFAP68CRYAB: 111,908,239–111,923,722, reverse strandCRYABHSPB2: 111,912,159–111,915,098, forward strandHSPB2HSPB2-C11orf52: 111,912,736–111,926,871, forward strandC11orf52: 111,918,032–111,926,873, forward strandDIXDC1: 111,927,144–112,023,091, forward strandDLAT: 112,025,033–112,064,404, forward strandDLATPIH1D2: 112,052,485–112,074,274, reverse strandPIH1D2NKAPD1: 112,074,086–112,085,152, forward strandNKAPD1TIMM8B: 112,082,730–112,086,799, reverse strandTIMM8BSDHD: 112,086,361–112,120,016, forward strandSDHD: 112,086,903–112,193,805, forward strandIL18: 112,142,701–112,164,391, reverse strandIL18TEX12: 112,167,313–112,173,057, forward strandTEX12BCO2: 112,175,472–112,225,895, forward strandBCO2PTS: 112,226,059–112,270,449, forward strandPTSPLET1: 112,248,153–112,260,860, reverse strandPLET1Diagram of ALG9: 15 exons on the reverse strand of chromosome 11Exon 14: 3 known disease-causing sitesExon 13: 2 known disease-causing sitesExon 12: 2 known disease-causing sitesExon 11: 4 known disease-causing sitesExon 10: 2 known disease-causing sitesExon 9: 1 known disease-causing siteExon 8: 1 known disease-causing siteExon 7: 4 known disease-causing sitesExon 5: 4 known disease-causing sitesExon 4: 1 known disease-causing siteExon 2: 2 known disease-causing sitesExon 1: 3 known disease-causing sitesExon 15: 111,782,195–111,786,520, 4,326 basesExon 14: 111,809,643–111,809,773, 131 basesExon 13: 111,836,165–111,836,294, 130 basesExon 12: 111,837,468–111,837,615, 148 basesExon 11: 111,838,249–111,838,399, 151 basesExon 10: 111,840,655–111,840,809, 155 basesExon 9: 111,844,601–111,844,723, 123 basesExon 8: 111,853,380–111,853,485, 106 basesExon 7: 111,853,649–111,853,736, 88 basesExon 6: 111,857,602–111,857,737, 136 basesExon 5: 111,860,547–111,860,635, 89 basesExon 4: 111,865,181–111,865,251, 71 basesExon 3: 111,868,602–111,868,736, 135 basesExon 2: 111,870,232–111,870,370, 139 basesExon 1: 111,871,352–111,871,581, 230 bases1510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 6.2 kb of the gene's 89.4 kb; 1,857 of those bases code for the protein.

How a genome test reads ALG9

38

positions in ALG9 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 89.4 kb of ALG9, introns included, not only the 6.2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ALG9 gene: ALG9 alpha-1,2-mannosyltransferase. Retrieved 17 October 2026, from https://dantelabs.com/genes/alg9

Vancouver

Dante Labs. ALG9 gene: ALG9 alpha-1,2-mannosyltransferase [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/alg9

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