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Gene

TMEM106B

transmembrane protein 106B

Summary

Cytogenetic location
7p21.3
Coordinates
Chromosome 7: 12,211,294–12,243,367 (GRCh38)
Exons
8 exons across 32.1 kb
Protein
274 amino acids
Inheritance
Autosomal dominant
Also known as
MGC33727, FLJ11273
MANE Select transcript
ENST00000396668.8NM_001134232.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Pelizaeus-Merzbacher Disease & Hypomyelinating Leukodystrophies

    • Hypomyelinating leukodystrophy 16 (TMEM106B)Autosomal dominant

      A rare inherited form of hypomyelinating leukodystrophy, in which myelin in the brain does not form normally, causing delayed development and movement problems.

      • ClinGen rates the link definitive
      • 4 GenCC submitters rate it definitive or strong

Broader groupings

  • Other Inherited Leukodystrophies

    • Leukodystrophy (other and unspecified types)

      One of 80 genes linked to it

      Inherited conditions that damage or prevent the normal formation of myelin, the white matter of the brain and spinal cord. Different types follow autosomal recessive, autosomal dominant or X-linked inheritance depending on the gene involved.

      • ClinGen rates the link definitive
      • 4 GenCC submitters rate it definitive or strong
      What knowing changes

      Knowing the specific genetic cause can end a diagnostic search, guide supportive care and surveillance, show whether a specific treatment exists, and allow testing of relatives.

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How TMEM106B is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 7, with a bracket where TMEM106B sits. TMEM106B and 5 genes near it on chromosome 7, from 11,727,331 to 12,727,330.Chromosome 77p21.3p22.3p22.2p22.1p21.3p21.2p21.1p15.3p15.2p15.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.21q11.22q11.23q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q31.1q31.2q31.31q31.32q31.33q32.1q32.2q32.3q33q34q35q36.1q36.2q36.311.8 Mb12 Mb12.2 Mb12.4 Mb12.6 MbTHSD7A: 11,370,365–11,832,450, reverse strandTHSD7ATMEM106B: 12,211,294–12,243,367, forward strandTMEM106BVWDE: 12,330,201–12,404,033, reverse strandVWDEC7orf78: 12,469,621–12,542,222, forward strandC7orf78SCIN: 12,570,577–12,660,182, forward strandSCINARL4A: 12,686,602–12,692,543, forward strandARL4ADiagram of TMEM106B: 8 exons on the forward strand of chromosome 7Exon 8: 1 known disease-causing siteExon 1: 12,211,294–12,211,425, 132 basesExon 2: 12,214,809–12,215,027, 219 basesExon 3: 12,218,458–12,218,521, 64 basesExon 4: 12,224,226–12,224,385, 160 basesExon 5: 12,229,679–12,229,819, 141 basesExon 6: 12,230,389–12,230,438, 50 basesExon 7: 12,231,062–12,231,115, 54 basesExon 8: 12,231,837–12,243,367, 11,531 bases123456785′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 12.4 kb of the gene's 32.1 kb; 825 of those bases code for the protein.

How a genome test reads TMEM106B

1

position in TMEM106B where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 32.1 kb of TMEM106B, introns included, not only the 12.4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TMEM106B gene: transmembrane protein 106B. Retrieved 16 October 2026, from https://dantelabs.com/genes/tmem106b

Vancouver

Dante Labs. TMEM106B gene: transmembrane protein 106B [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/tmem106b

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