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Gene

PIGC

phosphatidylinositol glycan anchor biosynthesis class C

Summary

Cytogenetic location
1q24.3
Coordinates
Chromosome 1: 172,441,457–172,444,069 (GRCh38)
Exons
2 exons across 2.6 kb
Protein
297 amino acids
Also known as
PIG-C, GPI2
MANE Select transcript
ENST00000344529.5NM_153747.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • GPI Anchor Biosynthesis Defects

    • Disorders of GPI Anchor Biosynthesis

      A group of inherited conditions caused by variants in the PIG, PGAP and related genes needed to make and attach the GPI anchor, typically causing developmental delay, low muscle tone and epilepsy.

      • 2 GenCC submitters rate it definitive or strong

Broader groupings

How PIGC is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where PIGC sits. PIGC and 4 genes near it on chromosome 1, from 171,942,763 to 172,942,762.Chromosome 11q24.3p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44172 Mb172.2 Mb172.4 Mb172.6 Mb172.8 MbDNM3: 171,817,887–172,418,466, forward strandDNM3C1orf105: 172,420,675–172,469,120, forward strandC1orf105PIGC: 172,441,457–172,444,069, reverse strandPIGCSUCO: 172,532,349–172,613,183, forward strandSUCOFASLG: 172,658,990–172,666,891, forward strandFASLGDiagram of PIGC: 2 exons on the reverse strand of chromosome 1Exon 2: 6 known disease-causing sitesExon 2: 172,441,457–172,442,830, 1,374 basesExon 1: 172,443,988–172,444,069, 82 bases215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.5 kb of the gene's 2.6 kb; 894 of those bases code for the protein.

How a genome test reads PIGC

6

positions in PIGC where ClinVar classes a change as pathogenic or likely pathogenic

6 of them (100%) fall in regions short reads find hard.

  • Segmental duplications (6 sites)Copies of at least 1 kb sharing at least 90% identity with another part of the genome (paralogues, pseudogenes); reads may align to the wrong copy.

A whole genome covers all 2.6 kb of PIGC, introns included, not only the 1.5 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). PIGC gene: phosphatidylinositol glycan anchor biosynthesis class C. Retrieved 16 October 2026, from https://dantelabs.com/genes/pigc

Vancouver

Dante Labs. PIGC gene: phosphatidylinositol glycan anchor biosynthesis class C [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/pigc

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