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Gene

NODAL

nodal growth differentiation factor

Summary

Cytogenetic location
10q22.1
Coordinates
Chromosome 10: 70,431,936–70,441,681 (GRCh38)
Exons
3 exons across 9.7 kb
Protein
347 amino acids
MANE Select transcript
ENST00000287139.8NM_018055.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Heterotaxy & Laterality Defects

    • Congenital Heart Disease with Heterotaxy

      Heart defects present at birth that occur together with variable left-right patterning defects of other organs.

      • ClinGen rates the link definitive
      • 1 GenCC submitter rates it definitive or strong
    • Visceral Heterotaxy

      Abnormal left-right arrangement of the internal organs, caused by changes in genes such as ZIC3 (X-linked), NODAL, CFC1, MMP21 and PKD1L1, often with complex heart defects and spleen abnormalities.

      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      Knowing about it supports heart and abdominal imaging, infection precautions if the spleen is absent, and reproductive counselling.

How NODAL is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 10, with a bracket where NODAL sits. NODAL and 15 genes near it on chromosome 10, from 69,936,809 to 70,936,808.Chromosome 1010q22.1p15.3p15.2p15.1p14p13p12.33p12.32p12.31p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.31q23.32q23.33q24.1q24.2q24.31q24.32q24.33q25.1q25.2q25.3q26.11q26.12q26.13q26.2q26.370 Mb70.2 Mb70.4 Mb70.6 Mb70.8 MbCOL13A1: 69,801,875–69,964,275, forward strandCOL13A1MACROH2A2: 70,052,544–70,112,282, forward strandMACROH2A2AIFM2: 70,054,661–70,133,269, reverse strandAIFM2TYSND1: 70,137,978–70,146,720, reverse strandTYSND1SAR1A: 70,147,289–70,186,284, reverse strandSAR1APPA1: 70,202,831–70,233,911, reverse strandPPA1NPFFR1: 70,247,329–70,284,011, reverse strandNPFFR1LRRC20: 70,298,970–70,382,650, reverse strandLRRC20EIF4EBP2: 70,404,130–70,428,618, forward strandEIF4EBP2NODAL: 70,431,936–70,441,681, reverse strandNODALPALD1: 70,477,658–70,668,754, forward strandPALD1PRF1: 70,596,401–70,602,788, reverse strandPRF1ADAMTS14: 70,672,367–70,762,441, forward strandADAMTS14TBATA: 70,771,238–70,785,401, reverse strandTBATASGPL1: 70,815,899–70,958,721, forward strandSGPL1PCBD1: 70,882,280–70,888,616, reverse strandPCBD1Diagram of NODAL: 3 exons on the reverse strand of chromosome 10Exon 2: 10 known disease-causing sitesExon 1: 1 known disease-causing siteExon 3: 70,431,936–70,433,088, 1,153 basesExon 2: 70,435,286–70,435,983, 698 basesExon 1: 70,441,475–70,441,681, 207 bases3215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.1 kb of the gene's 9.7 kb; 1,044 of those bases code for the protein.

How a genome test reads NODAL

13

positions in NODAL where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 9.7 kb of NODAL, introns included, not only the 2.1 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). NODAL gene: nodal growth differentiation factor. Retrieved 17 October 2026, from https://dantelabs.com/genes/nodal

Vancouver

Dante Labs. NODAL gene: nodal growth differentiation factor [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/nodal

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