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Gene

TGIF1

TGFB induced factor homeobox 1

Summary

Cytogenetic location
18p11.31
Coordinates
Chromosome 18: 3,450,172–3,459,978 (GRCh38)
Exons
3 exons across 9.8 kb
Protein
272 amino acids
Previous symbols
HPE4, TGIF
MANE Select transcript
ENST00000343820.10NM_003244.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Non-Acquired Combined Pituitary Hormone Deficiency

    • Congenital hypopituitarism is characterized by multiple pituitary hormone deficiency, including somatotroph, thyrotroph, lactotroph, corticotroph or gonadotroph deficiencies, due to mutations of pituitary transcription factors involved in pituitary ontogenesis.

      • 4 GenCC submitters rate it definitive or strong

How TGIF1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 18, with a bracket where TGIF1 sits. TGIF1 and 5 genes near it on chromosome 18, from 2,955,075 to 3,955,074.Chromosome 1818p11.31p11.32p11.31p11.23p11.22p11.21p11.1q11.1q11.2q12.1q12.2q12.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q233 Mb3.2 Mb3.4 Mb3.6 Mb3.8 MbLPIN2: 2,885,271–3,013,356, reverse strandLPIN2MYOM1: 3,066,693–3,220,210, reverse strandMYOM1MYL12A: 3,247,481–3,256,730, forward strandMYL12AMYL12B: 3,261,479–3,278,461, forward strandMYL12BTGIF1: 3,450,172–3,459,978, forward strandTGIF1DLGAP1: 3,494,443–4,455,307, reverse strandDLGAP1Diagram of TGIF1: 3 exons on the forward strand of chromosome 18Exon 2: 1 known disease-causing siteExon 3: 3 known disease-causing sitesExon 1: 3,450,172–3,450,505, 334 basesExon 2: 3,456,354–3,456,580, 227 basesExon 3: 3,457,365–3,459,978, 2,614 bases1235′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.2 kb of the gene's 9.8 kb; 819 of those bases code for the protein.

How a genome test reads TGIF1

4

positions in TGIF1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 9.8 kb of TGIF1, introns included, not only the 3.2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TGIF1 gene: TGFB induced factor homeobox 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/tgif1

Vancouver

Dante Labs. TGIF1 gene: TGFB induced factor homeobox 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/tgif1

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