Gene
TRAPPC11
trafficking protein particle complex subunit 11
- HGNC 25751(opens in a new tab)
- Ensembl gene ENSG00000168538(opens in a new tab)
- NCBI Gene 60684(opens in a new tab)
Summary
- Cytogenetic location
- 4q35.1
- Coordinates
- Chromosome 4: 183,659,293–183,713,589 (GRCh38)
- Exons
- 30 exons across 54.3 kb
- Protein
- 1,133 amino acids
- Also known as
- FLJ12716, gry, foigr
- Previous symbols
- C4orf41
- MANE Select transcript
- ENST00000334690.11NM_021942.6
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Limb-Girdle Muscular Dystrophy
Limb-girdle Muscular Dystrophy is defined as a collection of numerous subtypes with differing inheritance patterns (with diagnostic sufficiency being varied too). Carriers of variants related to the condition should seek guidance from a muscular-skeletal specialist for a definitive diagnosis.
- ClinGen rates the link definitive
- 6 GenCC submitters rate it definitive or strong
How TRAPPC11 is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 4.5 kb of the gene's 54.3 kb; 3,402 of those bases code for the protein.
How a genome test reads TRAPPC11
61
positions in TRAPPC11 where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
A whole genome covers all 54.3 kb of TRAPPC11, introns included, not only the 4.5 kb of exons.
Traits linked to TRAPPC11
The Human Phenotype Ontology lists these as features of the rare conditions TRAPPC11 can cause. Each trait's page lists the other genes linked to it.
Abnormality of the nervous system
- Abnormal gait
- Absent speech development
- Cerebral white matter atrophy
- Chorea
- Decreased reflex response
- Degeneration of cerebrum
- Global developmental delay
- Hyperactive movements
Show 20 more traits
- Instability or lack of coordination of central trunk muscles
- Intellectual disability
- Intellectual disability, borderline
- Waddling gait
- Ataxia
- CNS hypomyelination
- Degeneration of cerebellum
- Epilepsy
- Grand mal seizures
- Increased reflexes
- Loss of developmental milestones
- Motor axonal neuropathy
- EEG abnormality
- Difficulty articulating speech
- Dystonia
- Inability to walk
- Involuntary writhing movements in fingers, hands, toes, and feet
- Poor speech
- Speech apraxia
- Tremor
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
- The ACMG secondary findings list, SF v3.2.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). TRAPPC11 gene: trafficking protein particle complex subunit 11. Retrieved 16 October 2026, from https://dantelabs.com/genes/trappc11
Dante Labs. TRAPPC11 gene: trafficking protein particle complex subunit 11 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/trappc11
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