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Gene

MAPT

microtubule associated protein tau

Summary

Cytogenetic location
17q21.31
Coordinates
Chromosome 17: 45,894,554–46,028,334 (GRCh38)
Exons
13 exons across 133.8 kb
Protein
833 amino acids
Also known as
MTBT1, tau, PPND, FTDP-17, TAU, MSTD, MTBT2, FLJ31424, MGC138549, PPP1R103, tau-40, Tau-PHF6
Previous symbols
DDPAC, MAPTL
MANE Select transcript
ENST00000262410.10NM_001377265.1
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated reports relevant to this gene

  • Frontotemporal Dementia

    • Autosomal dominant

      Frontotemporal dementia (FTD) comprises a group of neurodegenerative disorders, characterized by progressive changes in behavior, executive dysfunction and language impairment, as a result of degeneration of the medial prefrontal and frontoinsular cortices. Four clinical subtypes have been identified: semantic dementia, progressive non-fluent aphasia, behavioral variant FTD and right temporal lobar atrophy.

      • 2 GenCC submitters rate it definitive or strong

  • Parkinson Disease

    • A progressive degenerative disorder of the central nervous system characterized by loss of dopamine producing neurons in the substantia nigra and the presence of Lewy bodies in the substantia nigra and locus coeruleus. Signs and symptoms include tremor which is most pronounced during rest, muscle rigidity, slowing of the voluntary movements, a tendency to fall back, and a mask-like facial expression.

      • 1 GenCC submitter rates it definitive or strong
      Actionability

      LRRK2 kinase inhibitor trials, substrate reduction therapy for GBA variants, α-synuclein-targeted approaches, dopaminergic medications, levodopa

How MAPT is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 17, with a bracket where MAPT sits. MAPT and 9 genes near it on chromosome 17, from 45,461,444 to 46,461,443.Chromosome 1717q21.31p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.345.6 Mb45.8 Mb46 Mb46.2 Mb46.4 MbPLEKHM1: 45,435,900–45,490,986, reverse strandPLEKHM1LINC02210-CRHR1: 45,620,344–45,835,826, forward strandLINC02210-CRHR1CRHR1: 45,784,277–45,835,828, forward strandCRHR1SPPL2C: 45,844,881–45,847,067, forward strandSPPL2CMAPT: 45,894,554–46,028,334, forward strandMAPTSTH: 45,999,250–45,999,694, forward strandSTHKANSL1: 46,029,916–46,225,389, reverse strandKANSL1ARL17B: 46,271,629–46,361,793, reverse strandARL17BLRRC37A: 46,292,733–46,338,077, forward strandLRRC37AARL17A: 46,431,431–46,579,725, reverse strandARL17ADiagram of MAPT: 13 exons on the forward strand of chromosome 17Exon 2: 1 known disease-causing siteExon 9: 1 known disease-causing siteExon 10: 8 known disease-causing sitesExon 11: 1 known disease-causing siteExon 12: 5 known disease-causing sitesExon 13: 2 known disease-causing sitesExon 1: 45,894,554–45,894,686, 133 basesExon 2: 45,962,321–45,962,470, 150 basesExon 3: 45,971,859–45,971,945, 87 basesExon 4: 45,978,375–45,978,440, 66 basesExon 5: 45,982,866–45,983,930, 1,065 basesExon 6: 45,987,040–45,987,095, 56 basesExon 7: 45,989,878–45,990,075, 198 basesExon 8: 45,991,460–45,991,586, 127 basesExon 9: 45,996,399–45,996,664, 266 basesExon 10: 46,010,310–46,010,402, 93 basesExon 11: 46,014,243–46,014,324, 82 basesExon 12: 46,018,618–46,018,730, 113 basesExon 13: 46,023,956–46,028,334, 4,379 bases124681012135′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 6.8 kb of the gene's 133.8 kb; 2,502 of those bases code for the protein.

Sequencing MAPT

21

positions in MAPT where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 133.8 kb of MAPT, introns included, not only the 6.8 kb of exons.

Genes linked to the same conditions

Traits linked to MAPT

The Human Phenotype Ontology lists these as features of the rare conditions MAPT can cause. Each trait's page lists the other genes linked to it.

Abnormality of the nervous system

Show 107 more traits

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). MAPT gene: microtubule associated protein tau. Retrieved 17 October 2026, from https://dantelabs.com/genes/mapt

Vancouver

Dante Labs. MAPT gene: microtubule associated protein tau [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/mapt

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