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Gene

FMN2

formin 2

Summary

Cytogenetic location
1q43
Coordinates
Chromosome 1: 240,091,883–240,475,187 (GRCh38)
Exons
18 exons across 383.3 kb
Protein
1,722 amino acids
MANE Select transcript
ENST00000319653.14NM_020066.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Curated report relevant to this gene

    How FMN2 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 1, with a bracket where FMN2 sits. FMN2 and 3 genes near it on chromosome 1, from 239,708,578 to 240,858,492.Chromosome 11q43p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44239.8 Mb240 Mb240.2 Mb240.4 Mb240.6 Mb240.8 MbCHRM3: 239,386,513–239,915,452, forward strandCHRM3FMN2: 240,091,883–240,475,187, forward strandFMN2GREM2: 240,489,573–240,612,162, reverse strandGREM2RGS7: 240,767,636–241,357,374, reverse strandRGS7Diagram of FMN2: 18 exons on the forward strand of chromosome 1Exon 1: 3 known disease-causing sitesExon 2: 1 known disease-causing siteExon 3: 1 known disease-causing siteExon 5: 5 known disease-causing sitesExon 11: 1 known disease-causing siteExon 12: 1 known disease-causing siteExon 1: 240,091,883–240,093,724, 1,842 basesExon 2: 240,123,179–240,123,345, 167 basesExon 3: 240,177,921–240,178,068, 148 basesExon 4: 240,188,207–240,188,262, 56 basesExon 5: 240,206,799–240,208,732, 1,934 basesExon 6: 240,211,091–240,211,235, 145 basesExon 7: 240,257,945–240,258,032, 88 basesExon 8: 240,294,822–240,294,883, 62 basesExon 9: 240,329,076–240,329,167, 92 basesExon 10: 240,329,339–240,329,468, 130 basesExon 11: 240,330,603–240,330,749, 147 basesExon 12: 240,333,887–240,333,946, 60 basesExon 13: 240,334,109–240,334,229, 121 basesExon 14: 240,355,816–240,355,908, 93 basesExon 15: 240,392,511–240,392,562, 52 basesExon 16: 240,438,061–240,438,210, 150 basesExon 17: 240,472,372–240,472,453, 82 basesExon 18: 240,474,128–240,475,187, 1,060 bases151015185′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 6.4 kb of the gene's 383.3 kb; 5,169 of those bases code for the protein.

    How a genome test reads FMN2

    12

    positions in FMN2 where ClinVar classes a change as pathogenic or likely pathogenic

    4 of them (33%) fall in regions short reads find hard.

    • Segmental duplications (4 sites)Copies of at least 1 kb sharing at least 90% identity with another part of the genome (paralogues, pseudogenes); reads may align to the wrong copy.

    A whole genome covers all 383.3 kb of FMN2, introns included, not only the 6.4 kb of exons.

    Genes linked to the same conditions

    Traits linked to FMN2

    The Human Phenotype Ontology lists these as features of the rare conditions FMN2 can cause. Each trait's page lists the other genes linked to it.

    External links

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). FMN2 gene: formin 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/fmn2

    Vancouver

    Dante Labs. FMN2 gene: formin 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/fmn2

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