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Gene

SYT1

synaptotagmin 1

Summary

Cytogenetic location
12q21.2
Coordinates
Chromosome 12: 78,864,774–79,452,008 (GRCh38)
Exons
11 exons across 587.2 kb
Protein
422 amino acids
Also known as
P65
Previous symbols
SYT, SVP65
MANE Select transcript
ENST00000261205.9NM_005639.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads SYT1 yet. The test sequences your whole genome, so your data includes it all the same.

How SYT1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 12, with a bracket where SYT1 sits. SYT1 and 2 genes near it on chromosome 12, from 78,277,539 to 80,039,243.Chromosome 1212q21.2p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.3378.5 Mb79 Mb79.5 Mb80 MbSYT1: 78,864,774–79,452,008, forward strandSYT1PAWR: 79,574,979–79,691,397, reverse strandPAWRPPP1R12A: 79,772,140–79,935,460, reverse strandPPP1R12ADiagram of SYT1: 11 exons on the forward strand of chromosome 12Exon 8: 1 known disease-causing siteExon 9: 5 known disease-causing sitesExon 10: 3 known disease-causing sitesExon 11: 4 known disease-causing sitesExon 1: 78,864,774–78,865,109, 336 basesExon 2: 78,977,799–78,977,931, 133 basesExon 3: 79,047,297–79,047,362, 66 basesExon 4: 79,217,503–79,217,685, 183 basesExon 5: 79,285,787–79,285,971, 185 basesExon 6: 79,292,008–79,292,130, 123 basesExon 7: 79,296,069–79,296,236, 168 basesExon 8: 79,299,384–79,299,551, 168 basesExon 9: 79,353,502–79,353,619, 118 basesExon 10: 79,444,073–79,444,206, 134 basesExon 11: 79,448,918–79,452,008, 3,091 bases1115′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.7 kb of the gene's 587.2 kb; 1,269 of those bases code for the protein.

How a genome test reads SYT1

13

positions in SYT1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 587.2 kb of SYT1, introns included, not only the 4.7 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). SYT1 gene: synaptotagmin 1. Retrieved 16 October 2026, from https://dantelabs.com/genes/syt1

Vancouver

Dante Labs. SYT1 gene: synaptotagmin 1 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/syt1

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