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Gene

SNAP25

synaptosome associated protein 25

Summary

Cytogenetic location
20p12.2
Coordinates
Chromosome 20: 10,218,830–10,307,418 (GRCh38)
Exons
8 exons across 88.6 kb
Protein
206 amino acids
Also known as
SNAP-25, RIC-4, RIC4, SEC9, bA416N4.2, dJ1068F16.2
Previous symbols
SNAP
MANE Select transcript
ENST00000254976.7NM_130811.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Congenital Myasthenic Syndrome

    • Congenital Myasthenic Syndrome (All Types)

      Umbrella term covering all congenital myasthenic syndromes, including the common CHRNE, RAPSN, DOK7 and MUSK forms.

      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      Many forms respond to specific medications such as pyridostigmine, salbutamol or ephedrine, and the right choice depends on the gene involved.

Broader groupings

  • Epilepsy (Full Panel)

    • Epilepsy

      One of 171 genes linked to it

      A brain disorder characterized by episodes of abnormally increased neuronal discharge resulting in transient episodes of sensory or motor neurological dysfunction, or psychic dysfunction. These episodes may or may not be associated with loss of consciousness or convulsions.

      • ClinGen rates the link definitive
      • 3 GenCC submitters rate it definitive or strong

How SNAP25 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 20, with a bracket where SNAP25 sits. SNAP25 and 7 genes near it on chromosome 20, from 9,763,124 to 10,763,123.Chromosome 2020p12.2p13p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q12q13.11q13.12q13.13q13.2q13.31q13.32q13.339.8 Mb10 Mb10.2 Mb10.4 Mb10.6 MbPAK5: 9,537,370–9,839,076, reverse strandPAK5ANKEF1: 9,986,126–10,059,414, forward strandANKEF1SNAP25: 10,218,830–10,307,418, forward strandSNAP25MKKS: 10,401,009–10,434,236, reverse strandMKKS: 10,411,653–10,434,236, reverse strand: 10,411,653–10,434,236, reverse strandSLX4IP: 10,434,668–10,638,912, forward strandSLX4IPJAG1: 10,637,684–10,674,396, reverse strandJAG1Diagram of SNAP25: 8 exons on the forward strand of chromosome 20Exon 3: 1 known disease-causing siteExon 4: 4 known disease-causing sitesExon 5: 3 known disease-causing sitesExon 6: 1 known disease-causing siteExon 7: 8 known disease-causing sitesExon 8: 6 known disease-causing sitesExon 1: 10,218,830–10,218,977, 148 basesExon 2: 10,275,429–10,275,563, 135 basesExon 3: 10,277,685–10,277,726, 42 basesExon 4: 10,284,724–10,284,772, 49 basesExon 5: 10,293,161–10,293,278, 118 basesExon 6: 10,296,925–10,297,050, 126 basesExon 7: 10,299,268–10,299,412, 145 basesExon 8: 10,306,129–10,307,418, 1,290 bases123456785′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.1 kb of the gene's 88.6 kb; 621 of those bases code for the protein.

How a genome test reads SNAP25

26

positions in SNAP25 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 88.6 kb of SNAP25, introns included, not only the 2.1 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). SNAP25 gene: synaptosome associated protein 25. Retrieved 17 October 2026, from https://dantelabs.com/genes/snap25

Vancouver

Dante Labs. SNAP25 gene: synaptosome associated protein 25 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/snap25

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