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Gene

NGLY1

N-glycanase 1

Summary

Cytogenetic location
3p24.2
Coordinates
Chromosome 3: 25,718,944–25,783,443 (GRCh38)
Exons
12 exons across 64.5 kb
Protein
654 amino acids
Also known as
FLJ11005, PNG1, PNG-1
MANE Select transcript
ENST00000280700.10NM_018297.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads NGLY1 yet. The test sequences your whole genome, so your data includes it all the same.

How NGLY1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 3, with a bracket where NGLY1 sits. NGLY1 and 3 genes near it on chromosome 3, from 25,251,194 to 26,251,193.Chromosome 33p24.2p26.3p26.2p26.1p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13.11q13.12q13.13q13.2q13.31q13.32q13.33q21.1q21.2q21.3q22.1q22.2q22.3q23q24q25.1q25.2q25.31q25.32q25.33q26.1q26.2q26.31q26.32q26.33q27.1q27.2q27.3q28q2925.4 Mb25.6 Mb25.8 Mb26 Mb26.2 MbRARB: 24,687,887–25,597,932, forward strandRARBTOP2B: 25,597,978–25,664,973, reverse strandTOP2BNGLY1: 25,718,944–25,783,443, reverse strandNGLY1OXSM: 25,782,917–25,797,141, forward strandOXSMDiagram of NGLY1: 12 exons on the reverse strand of chromosome 3Exon 12: 6 known disease-causing sitesExon 11: 13 known disease-causing sitesExon 10: 13 known disease-causing sitesExon 9: 6 known disease-causing sitesExon 8: 8 known disease-causing sitesExon 7: 5 known disease-causing sitesExon 6: 10 known disease-causing sitesExon 5: 8 known disease-causing sitesExon 4: 7 known disease-causing sitesExon 3: 11 known disease-causing sitesExon 2: 4 known disease-causing sitesExon 1: 9 known disease-causing sitesExon 12: 25,718,944–25,719,635, 692 basesExon 11: 25,720,014–25,720,191, 178 basesExon 10: 25,729,133–25,729,318, 186 basesExon 9: 25,732,319–25,732,483, 165 basesExon 8: 25,733,872–25,733,982, 111 basesExon 7: 25,736,004–25,736,149, 146 basesExon 6: 25,737,334–25,737,455, 122 basesExon 5: 25,739,577–25,739,799, 223 basesExon 4: 25,751,098–25,751,263, 166 basesExon 3: 25,764,066–25,764,311, 246 basesExon 2: 25,778,574–25,778,688, 115 basesExon 1: 25,783,260–25,783,443, 184 bases1210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.5 kb of the gene's 64.5 kb; 1,965 of those bases code for the protein.

How a genome test reads NGLY1

109

positions in NGLY1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 64.5 kb of NGLY1, introns included, not only the 2.5 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). NGLY1 gene: N-glycanase 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/ngly1

Vancouver

Dante Labs. NGLY1 gene: N-glycanase 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/ngly1

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