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Gene

RRAS

RAS related

Summary

Cytogenetic location
19q13.33
Coordinates
Chromosome 19: 49,635,292–49,640,143 (GRCh38)
Exons
6 exons across 4.9 kb
Protein
218 amino acids
Inheritance
Autosomal dominant
Also known as
R-Ras, RRAS1
MANE Select transcript
ENST00000246792.4NM_006270.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Noonan Syndrome

    • Noonan Syndrome and Noonan-Related Syndromes

      A group of RAS pathway conditions, including Noonan, Costello, cardiofaciocutaneous and Legius syndromes, with variable heart defects, short stature and distinctive facial features.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Knowing about it supports heart, growth and developmental assessment.

Broader groupings

  • Hypertrophic Cardiomyopathy

    • Autosomal dominant

      One of 62 genes linked to it

      A condition in which the myocardium is hypertrophied without an obvious cause. The hypertrophy is generally asymmetric and may be associated with obstruction of the ventricular outflow tract.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Beta-blockers, non-dihydropyridine calcium channel blockers, activity restriction, genetic counseling

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How RRAS is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 19, with a bracket where RRAS sits. RRAS and 44 genes near it on chromosome 19, from 49,137,718 to 50,137,717.Chromosome 1919q13.33p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.4349.2 Mb49.4 Mb49.6 Mb49.8 Mb50 MbPPFIA3: 49,119,401–49,151,027, forward strandPPFIA3HRC: 49,151,014–49,155,441, reverse strandHRCTRPM4: 49,157,737–49,211,841, forward strandTRPM4SLC6A16: 49,289,638–49,325,215, reverse strandSLC6A16CD37: 49,335,171–49,343,335, forward strandCD37TEAD2: 49,340,389–49,362,729, reverse strandTEAD2DKKL1: 49,361,783–49,375,120, forward strandDKKL1KASH5: 49,388,219–49,417,990, forward strandKASH5PTH2: 49,422,419–49,423,660, reverse strandPTH2GFY: 49,423,749–49,428,987, forward strandGFYSLC17A7: 49,429,399–49,443,197, reverse strandPIH1D1: 49,446,291–49,453,537, reverse strandALDH16A1: 49,453,146–49,471,052, forward strand: 49,462,752–49,486,231, forward strandFLT3LG: 49,474,150–49,486,233, forward strandFLT3LGRPL13A: 49,487,510–49,493,057, forward strandRPL13ARPS11: 49,496,233–49,499,903, forward strandRPS11FCGRT: 49,506,806–49,526,917, forward strandFCGRTRCN3: 49,526,534–49,579,703, forward strandRCN3NOSIP: 49,555,207–49,592,927, reverse strandNOSIPPRRG2: 49,580,646–49,591,004, forward strandPRRG2PRR12: 49,591,108–49,626,439, forward strandPRR12RRAS: 49,635,292–49,640,143, reverse strandRRASSCAF1: 49,640,488–49,658,649, forward strandSCAF1IRF3: 49,659,569–49,665,864, reverse strandIRF3BCL2L12: 49,664,622–49,673,917, forward strandBCL2L12PRMT1: 49,675,786–49,689,029, forward strandADM5: 49,688,953–49,690,575, forward strandCPT1C: 49,690,898–49,713,733, forward strandTSKS: 49,739,753–49,763,329, reverse strandTSKSAP2A1: 49,766,912–49,807,114, forward strandAP2A1FUZ: 49,806,866–49,817,376, reverse strandFUZMED25: 49,818,269–49,840,384, forward strandMED25PTOV1: 49,850,735–49,860,744, forward strandPTOV1PNKP: 49,859,882–49,878,351, reverse strandPNKPAKT1S1: 49,869,023–49,879,470, reverse strandAKT1S1TBC1D17: 49,877,501–49,888,751, forward strandIL4I1: 49,889,654–49,929,926, reverse strandIL4I1NUP62: 49,906,825–49,929,926, reverse strandNUP62: 49,909,501–49,958,391, reverse strandATF5: 49,923,910–49,933,935, forward strandATF5SIGLEC11: 49,948,910–49,961,172, reverse strandSIGLEC16: 49,969,600–49,975,819, forward strandVRK3: 49,974,537–50,025,946, reverse strandVRK3ZNF473: 50,025,714–50,053,414, forward strandZNF473Diagram of RRAS: 6 exons on the reverse strand of chromosome 19Exon 6: 49,635,292–49,635,660, 369 basesExon 5: 49,635,734–49,635,852, 119 basesExon 4: 49,636,619–49,636,727, 109 basesExon 3: 49,636,824–49,636,926, 103 basesExon 2: 49,637,043–49,637,130, 88 basesExon 1: 49,639,946–49,640,143, 198 bases6543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1 kb of the gene's 4.9 kb; 657 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). RRAS gene: RAS related. Retrieved 16 October 2026, from https://dantelabs.com/genes/rras

Vancouver

Dante Labs. RRAS gene: RAS related [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/rras

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