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Gene

RAP1B

RAP1B, member of RAS oncogene family

Summary

Cytogenetic location
12q15
Coordinates
Chromosome 12: 68,610,899–68,671,901 (GRCh38)
Exons
8 exons across 61 kb
Protein
184 amino acids
Also known as
K-REV, RAL1B, DKFZp586H0723
MANE Select transcript
ENST00000250559.14NM_001010942.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Inherited Thrombocytopenias

    • Inherited Thrombocytopenia

      A group of conditions causing a lifelong low platelet count, linked to genes such as MYH9, ANKRD26, ETV6, WAS, MPL, RBM8A, GATA1 and MECOM, and inherited in dominant, recessive or X-linked patterns.

      • ClinGen rates the link moderate
      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      A genetic diagnosis avoids misdiagnosis as immune thrombocytopenia, with unnecessary steroids or spleen removal, and guides monitoring for related kidney, hearing or blood problems.

How RAP1B is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 12, with a bracket where RAP1B sits. RAP1B and 8 genes near it on chromosome 12, from 68,141,400 to 69,141,399.Chromosome 1212q15p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.3368.2 Mb68.4 Mb68.6 Mb68.8 Mb69 MbIFNG: 68,154,768–68,159,748, reverse strandIFNGIL26: 68,201,349–68,225,813, reverse strandIL26IL22: 68,248,242–68,253,604, reverse strandIL22SAXO6: 68,272,443–68,332,396, reverse strandSAXO6RAP1B: 68,610,899–68,671,901, forward strandRAP1BNUP107: 68,686,951–68,745,809, forward strandNUP107SLC35E3: 68,746,080–68,793,974, forward strandSLC35E3MDM2: 68,808,141–68,845,544, forward strandMDM2CPM: 68,842,192–68,971,570, reverse strandCPMDiagram of RAP1B: 8 exons on the forward strand of chromosome 12Exon 2: 1 known disease-causing siteExon 1: 68,610,899–68,611,043, 145 basesExon 2: 68,648,699–68,648,781, 83 basesExon 3: 68,650,400–68,650,468, 69 basesExon 4: 68,651,995–68,652,051, 57 basesExon 5: 68,654,112–68,654,252, 141 basesExon 6: 68,656,306–68,656,449, 144 basesExon 7: 68,657,101–68,657,217, 117 basesExon 8: 68,659,280–68,671,901, 12,622 bases124685′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 13.4 kb of the gene's 61 kb; 555 of those bases code for the protein.

How a genome test reads RAP1B

1

position in RAP1B where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 61 kb of RAP1B, introns included, not only the 13.4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). RAP1B gene: RAP1B, member of RAS oncogene family. Retrieved 17 October 2026, from https://dantelabs.com/genes/rap1b

Vancouver

Dante Labs. RAP1B gene: RAP1B, member of RAS oncogene family [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/rap1b

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