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Gene

TRIP11

thyroid hormone receptor interactor 11

Summary

Cytogenetic location
14q32.12
Coordinates
Chromosome 14: 91,965,991–92,040,059 (GRCh38)
Exons
21 exons across 74.1 kb
Protein
1,979 amino acids
Also known as
CEV14, Trip230, GMAP-210, GMAP210
MANE Select transcript
ENST00000267622.8NM_004239.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Achondrogenesis panel

    • Achondrogenesis

      Achondrogenesis describes a rare group of lethal skeletal dysplasias characterized by an endochondral ossification deficiency that leads to dwarfism with extreme micromelia, a small thorax, a prominent abdomen, anasarca and polyhydramnios. There are three types of achondrogenesis that exist and that differ clinically, radiologically, histologically and genetically: achondrogensis type 1a, type 1b and type 2.

      • 3 GenCC submitters rate it definitive or strong

How TRIP11 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 14, with a bracket where TRIP11 sits. TRIP11 and 8 genes near it on chromosome 14, from 91,503,025 to 92,503,024.Chromosome 1414q32.12p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.11q32.12q32.13q32.2q32.31q32.32q32.3391.6 Mb91.8 Mb92 Mb92.2 Mb92.4 MbPPP4R3A: 91,457,139–91,510,556, reverse strandPPP4R3ACATSPERB: 91,580,696–91,780,707, reverse strandCATSPERBTC2N: 91,779,746–91,867,536, reverse strandTC2NFBLN5: 91,869,410–91,948,064, reverse strandFBLN5TRIP11: 91,965,991–92,040,059, reverse strandTRIP11ATXN3: 92,044,482–92,106,625, reverse strandATXN3NDUFB1: 92,115,820–92,121,978, reverse strandNDUFB1CPSF2: 92,121,512–92,172,145, forward strandCPSF2SLC24A4: 92,322,581–92,501,481, forward strandSLC24A4Diagram of TRIP11: 21 exons on the reverse strand of chromosome 14Exon 19: 1 known disease-causing siteExon 18: 3 known disease-causing sitesExon 17: 2 known disease-causing sitesExon 13: 1 known disease-causing siteExon 11: 33 known disease-causing sitesExon 10: 1 known disease-causing siteExon 9: 2 known disease-causing sitesExon 7: 5 known disease-causing sitesExon 6: 4 known disease-causing sitesExon 5: 1 known disease-causing siteExon 4: 4 known disease-causing sitesExon 3: 1 known disease-causing siteExon 1: 1 known disease-causing siteExon 21: 91,965,991–91,969,893, 3,903 basesExon 20: 91,972,717–91,972,861, 145 basesExon 19: 91,974,627–91,974,743, 117 basesExon 18: 91,975,172–91,975,286, 115 basesExon 17: 91,976,108–91,976,189, 82 basesExon 16: 91,988,284–91,988,383, 100 basesExon 15: 91,993,809–91,993,912, 104 basesExon 14: 91,995,352–91,995,515, 164 basesExon 13: 91,999,240–91,999,433, 194 basesExon 12: 91,999,968–92,000,108, 141 basesExon 11: 92,003,419–92,006,448, 3,030 basesExon 10: 92,007,640–92,007,852, 213 basesExon 9: 92,010,986–92,011,072, 87 basesExon 8: 92,011,755–92,011,795, 41 basesExon 7: 92,014,215–92,014,577, 363 basesExon 6: 92,015,696–92,015,861, 166 basesExon 5: 92,017,682–92,017,750, 69 basesExon 4: 92,021,556–92,021,831, 276 basesExon 3: 92,025,310–92,025,420, 111 basesExon 2: 92,033,192–92,033,253, 62 basesExon 1: 92,039,547–92,040,059, 513 bases21201816141210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 10 kb of the gene's 74.1 kb; 5,940 of those bases code for the protein.

How a genome test reads TRIP11

70

positions in TRIP11 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 74.1 kb of TRIP11, introns included, not only the 10 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TRIP11 gene: thyroid hormone receptor interactor 11. Retrieved 17 October 2026, from https://dantelabs.com/genes/trip11

Vancouver

Dante Labs. TRIP11 gene: thyroid hormone receptor interactor 11 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/trip11

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