Gene
TRAF7
TNF receptor associated factor 7
- HGNC 20456↗(opens in a new tab)
- Ensembl gene ENSG00000131653↗(opens in a new tab)
- NCBI Gene 84231↗(opens in a new tab)
Summary
- Cytogenetic location
- 16p13.3
- Coordinates
- Chromosome 16: 2,155,782–2,178,129 (GRCh38)
- Exons
- 21 exons across 22.3 kb
- Protein
- 670 amino acids
- Also known as
- RNF119, DKFZp586I021, MGC7807
- Previous symbols
- RFWD1
- MANE Select transcript
- ENST00000326181.11NM_032271.3
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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No Genome Test report reads TRAF7 yet. The test sequences your whole genome, so your data includes it all the same.
How TRAF7 is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 3.7 kb of the gene's 22.3 kb; 2,013 of those bases code for the protein.
How a genome test reads TRAF7
12
positions in TRAF7 where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
A whole genome covers all 22.3 kb of TRAF7, introns included, not only the 3.7 kb of exons.
Traits linked to TRAF7
The Human Phenotype Ontology lists these as features of the rare conditions TRAF7 can cause. Each trait's page lists the other genes linked to it.
Abnormality of the nervous system
- Global developmental delay
- Intracranial meningioma
- Abnormal brain FDG positron emission tomography
- Delayed speech and language development
- Epilepsy
- Focal T2 hypointense thalamic lesion
- Headache
- Intellectual disability
Show 25 more traits
- Motor delay
- Seizure affecting one half of brain
- Tethered cord
- Abnormal central motor function
- Abnormal central sensory function
- Abnormal gait
- Abnormality of the cerebellum
- Ataxia
- Autism spectrum disorder
- Cognitive impairment
- Cranial nerve paralysis
- Degeneration of cerebrum
- Memory impairment
- Rise in pressure inside skull
- Spinal meningioma
- Too much cerebrospinal fluid in the brain
- Trigeminal neuralgia
- Ventriculomegaly
- Weakness of one side of body
- Abnormal speech pattern
- Brain stem compression
- Can't control feelings
- Excessive daytime sleepiness
- Spasms on one side of the face
- Transient global amnesia
Abnormality of the endocrine system
- Decreased circulating ACTH concentration
- Decreased circulating follicle stimulating hormone concentration
- Decreased circulating luteinizing hormone level
- Decreased serum estradiol
- Decreased serum testosterone level
- Hypogonadotropic hypogonadism
- Increased circulating prolactin concentration
- Low blood cortisol level
Show 8 more traits
Abnormality of limbs
- Curvature of digit
- Decreased arm strength
- Dropped arches
- Finger bends toward pinky
- Fluid accumulation in lower limbs
- Gap between 1st and 2nd toes
- Long big toe
- Lower limb muscle weakness
Show 3 more traits
Abnormality of the musculoskeletal system
- Low muscle tone
- Pigeon chest
- Delayed bone maturation
- Double-Jointed
- Functional motor deficit
- Joint contracture
- Scoliosis
- Spasticity and rigidity of muscles
Show 1 more trait
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). TRAF7 gene: TNF receptor associated factor 7. Retrieved 16 October 2026, from https://dantelabs.com/genes/traf7
Dante Labs. TRAF7 gene: TNF receptor associated factor 7 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/traf7
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