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Gene

TBX3

T-box transcription factor 3

Summary

Cytogenetic location
12q24.21
Coordinates
Chromosome 12: 114,670,255–114,684,175 (GRCh38)
Exons
7 exons across 13.9 kb
Protein
723 amino acids
Also known as
TBX3-ISO, XHL
Previous symbols
UMS
MANE Select transcript
ENST00000349155.7NM_005996.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads TBX3 yet. The test sequences your whole genome, so your data includes it all the same.

How TBX3 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 12, with a bracket where TBX3 sits. TBX3 and 1 gene near it on chromosome 12, from 114,177,215 to 115,177,214.Chromosome 1212q24.21p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.33114.2 Mb114.4 Mb114.6 Mb114.8 Mb115 MbTBX5: 114,353,911–114,409,103, reverse strandTBX5TBX3: 114,670,255–114,684,175, reverse strandTBX3Diagram of TBX3: 7 exons on the reverse strand of chromosome 12Exon 7: 1 known disease-causing siteExon 6: 5 known disease-causing sitesExon 5: 4 known disease-causing sitesExon 4: 1 known disease-causing siteExon 3: 1 known disease-causing siteExon 2: 4 known disease-causing sitesExon 1: 5 known disease-causing sitesExon 7: 114,670,255–114,672,302, 2,048 basesExon 6: 114,674,165–114,674,835, 671 basesExon 5: 114,676,313–114,676,470, 158 basesExon 4: 114,677,580–114,677,656, 77 basesExon 3: 114,679,505–114,679,651, 147 basesExon 2: 114,680,879–114,681,146, 268 basesExon 1: 114,682,812–114,684,175, 1,364 bases76543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.7 kb of the gene's 13.9 kb; 2,172 of those bases code for the protein.

How a genome test reads TBX3

23

positions in TBX3 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 13.9 kb of TBX3, introns included, not only the 4.7 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TBX3 gene: T-box transcription factor 3. Retrieved 17 October 2026, from https://dantelabs.com/genes/tbx3

Vancouver

Dante Labs. TBX3 gene: T-box transcription factor 3 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/tbx3

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