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Gene

PIGS

phosphatidylinositol glycan anchor biosynthesis class S

Summary

Cytogenetic location
17q11.2
Coordinates
Chromosome 17: 28,553,387–28,571,524 (GRCh38)
Exons
12 exons across 18.1 kb
Protein
555 amino acids
Also known as
PIG-S
MANE Select transcript
ENST00000308360.8NM_033198.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • GPI Anchor Biosynthesis Defects

    • Disorders of GPI Anchor Biosynthesis

      A group of inherited conditions caused by variants in the PIG, PGAP and related genes needed to make and attach the GPI anchor, typically causing developmental delay, low muscle tone and epilepsy.

      • ClinGen rates the link definitive
      • 4 GenCC submitters rate it definitive or strong

Broader groupings

  • Epilepsy (Full Panel)

    • Epilepsy

      One of 171 genes linked to it

      A brain disorder characterized by episodes of abnormally increased neuronal discharge resulting in transient episodes of sensory or motor neurological dysfunction, or psychic dysfunction. These episodes may or may not be associated with loss of consciousness or convulsions.

      • ClinGen rates the link definitive
      • 4 GenCC submitters rate it definitive or strong

How PIGS is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 17, with a bracket where PIGS sits. PIGS and 34 genes near it on chromosome 17, from 28,062,456 to 29,062,455.Chromosome 1717q11.2p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.328.2 Mb28.4 Mb28.6 Mb28.8 Mb29 MbNLK: 28,041,709–28,196,381, forward strandNLKTMEM97: 28,319,097–28,332,671, forward strandIFT20: 28,328,319–28,335,489, reverse strandTNFAIP1: 28,335,572–28,349,943, forward strandPOLDIP2: 28,343,133–28,357,623, reverse strandVMA12: 28,357,636–28,363,683, forward strandSEBOX: 28,363,506–28,365,199, reverse strand: 28,364,288–28,368,012, reverse strandSARM1: 28,364,356–28,404,049, forward strandSARM1VTN: 28,366,414–28,373,091, reverse strandVTNSLC46A1: 28,394,642–28,407,197, reverse strandSLC46A1RSKR: 28,455,752–28,614,210, reverse strandSLC13A2: 28,473,275–28,497,782, forward strandSLC13A2FOXN1: 28,506,243–28,538,900, forward strandFOXN1UNC119: 28,546,705–28,552,655, reverse strandUNC119PIGS: 28,553,387–28,571,524, reverse strandPIGSALDOC: 28,573,115–28,576,948, reverse strandALDOCSPAG5: 28,577,565–28,599,052, reverse strandSPAG5: 28,580,012–28,614,185, reverse strandBLTP2: 28,614,440–28,645,454, reverse strandBLTP2SDF2: 28,648,346–28,662,189, reverse strandSDF2SUPT6H: 28,661,920–28,702,682, forward strandSUPT6HPROCA1: 28,703,196–28,712,313, reverse strandPROCA1RAB34: 28,713,545–28,719,594, reverse strandRAB34RPL23A: 28,719,940–28,724,365, forward strandRPL23ATLCD1: 28,723,435–28,727,935, reverse strandNEK8: 28,725,897–28,743,455, forward strandTRAF4: 28,743,978–28,772,894, forward strandFAM222B: 28,755,966–28,855,232, reverse strandFAM222BERAL1: 28,854,983–28,861,067, forward strandERAL1FLOT2: 28,879,335–28,897,741, reverse strandFLOT2DHRS13: 28,897,781–28,903,087, reverse strandDHRS13PHF12: 28,905,247–28,951,771, reverse strandPHF12PIPOX: 28,950,513–29,057,583, forward strandPIPOXSEZ6: 28,954,901–29,006,440, reverse strandSEZ6Diagram of PIGS: 12 exons on the reverse strand of chromosome 17Exon 12: 1 known disease-causing siteExon 9: 1 known disease-causing siteExon 8: 1 known disease-causing siteExon 7: 2 known disease-causing sitesExon 6: 1 known disease-causing siteExon 2: 2 known disease-causing sitesExon 12: 28,553,387–28,554,495, 1,109 basesExon 11: 28,554,851–28,555,061, 211 basesExon 10: 28,556,166–28,556,266, 101 basesExon 9: 28,556,827–28,556,972, 146 basesExon 8: 28,558,476–28,558,590, 115 basesExon 7: 28,560,049–28,560,191, 143 basesExon 6: 28,561,422–28,561,629, 208 basesExon 5: 28,563,431–28,563,522, 92 basesExon 4: 28,563,818–28,563,907, 90 basesExon 3: 28,570,852–28,570,963, 112 basesExon 2: 28,571,049–28,571,188, 140 basesExon 1: 28,571,463–28,571,524, 62 bases1210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.5 kb of the gene's 18.1 kb; 1,668 of those bases code for the protein.

How a genome test reads PIGS

8

positions in PIGS where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 18.1 kb of PIGS, introns included, not only the 2.5 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). PIGS gene: phosphatidylinositol glycan anchor biosynthesis class S. Retrieved 16 October 2026, from https://dantelabs.com/genes/pigs

Vancouver

Dante Labs. PIGS gene: phosphatidylinositol glycan anchor biosynthesis class S [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/pigs

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