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Gene

FKBP10

FKBP prolyl isomerase 10

Summary

Cytogenetic location
17q21.2
Coordinates
Chromosome 17: 41,813,004–41,823,213 (GRCh38)
Exons
10 exons across 10.2 kb
Protein
582 amino acids
Inheritance
Autosomal recessive
Also known as
hFKBP65, FKBP65, FLJ22041, FKBP6, FLJ20683, FLJ23833
MANE Select transcript
ENST00000321562.9NM_021939.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Osteogenesis Imperfecta

    • Bruck syndrome 1Autosomal recessive

      A form of osteogenesis imperfecta caused by FKBP10 variants, combining bone fragility and fractures with joint contractures present from birth.

      • 2 GenCC submitters rate it definitive or strong

    • A group of inherited connective tissue disorders causing fragile bones that break easily, often with blue sclerae, hearing loss and dental problems.

      • 4 GenCC submitters rate it definitive or strong
      What knowing changes

      Cyclic IV bisphosphonates (pamidronate, zoledronate); orthopedic rodding of long bones; physical therapy; denosumab (in clinical use for pediatric OI); romosozumab (in development); hearing monitoring; dental management for dentinogenesis imperfecta

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How FKBP10 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 17, with a bracket where FKBP10 sits. FKBP10 and 42 genes near it on chromosome 17, from 41,318,109 to 42,318,108.Chromosome 1717q21.2p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.341.4 Mb41.6 Mb41.8 Mb42 Mb42.2 MbKRT33A: 41,345,665–41,350,828, reverse strandKRT33AKRT33B: 41,363,498–41,369,813, reverse strandKRT33BKRT34: 41,377,669–41,382,306, reverse strandKRT34KRT31: 41,393,721–41,397,611, reverse strandKRT31KRT37: 41,420,547–41,424,585, reverse strandKRT37KRT38: 41,436,154–41,440,983, reverse strandKRT38KRT32: 41,459,513–41,467,386, reverse strandKRT32KRT35: 41,476,710–41,481,151, reverse strandKRT36: 41,486,136–41,492,546, reverse strandKRT36KRT13: 41,500,981–41,505,758, reverse strandKRT13KRT15: 41,513,745–41,522,529, reverse strandKRT15KRT19: 41,523,613–41,528,370, reverse strandKRT19KRT9: 41,565,836–41,572,059, reverse strandKRT9KRT14: 41,582,279–41,586,896, reverse strandKRT14KRT16: 41,609,778–41,615,899, reverse strandKRT16KRT17: 41,619,437–41,624,842, reverse strandKRT17EIF1: 41,688,883–41,693,623, forward strandEIF1GAST: 41,710,999–41,715,973, forward strandGASTHAP1: 41,717,742–41,734,646, reverse strandHAP1JUP: 41,750,887–41,797,798, reverse strandJUPP3H4: 41,801,944–41,812,750, reverse strandP3H4FKBP10: 41,813,004–41,823,213, forward strandFKBP10NT5C3B: 41,823,972–41,836,271, reverse strandNT5C3BKLHL10: 41,835,685–41,848,384, forward strandKLHL10KLHL11: 41,848,513–41,865,430, reverse strandACLY: 41,866,916–41,930,551, reverse strandACLYODAD4: 41,930,599–41,966,503, forward strandODAD4CNP: 41,966,729–41,977,740, forward strandCNPDNAJC7: 41,974,005–42,021,376, reverse strandDNAJC7NKIRAS2: 42,011,382–42,025,644, forward strandNKIRAS2ZNF385C: 42,025,576–42,098,479, reverse strandZNF385CC17orf113: 42,038,232–42,050,601, reverse strandC17orf113DHX58: 42,101,404–42,112,735, reverse strandDHX58KAT2A: 42,113,109–42,121,382, reverse strandKAT2A: 42,119,674–42,154,916, reverse strandHSPB9: 42,122,804–42,123,352, forward strandHSPB9RAB5C: 42,124,976–42,155,044, reverse strandKCNH4: 42,156,891–42,181,146, reverse strandHCRT: 42,184,060–42,185,452, reverse strandHCRTGHDC: 42,188,799–42,194,513, reverse strandGHDCSTAT5B: 42,199,176–42,288,633, reverse strandSTAT5BSTAT5A: 42,287,547–42,311,943, forward strandSTAT5ASTAT3: 42,313,322–42,388,574, reverse strandSTAT3Diagram of FKBP10: 10 exons on the forward strand of chromosome 17Exon 1: 7 known disease-causing sitesExon 2: 5 known disease-causing sitesExon 3: 1 known disease-causing siteExon 4: 2 known disease-causing sitesExon 5: 7 known disease-causing sitesExon 6: 7 known disease-causing sitesExon 7: 1 known disease-causing siteExon 8: 2 known disease-causing sitesExon 9: 2 known disease-causing sitesExon 10: 2 known disease-causing sitesExon 1: 41,813,004–41,813,279, 276 basesExon 2: 41,817,058–41,817,203, 146 basesExon 3: 41,818,089–41,818,278, 190 basesExon 4: 41,818,382–41,818,527, 146 basesExon 5: 41,819,210–41,819,399, 190 basesExon 6: 41,819,530–41,819,675, 146 basesExon 7: 41,820,269–41,820,461, 193 basesExon 8: 41,820,947–41,821,089, 143 basesExon 9: 41,821,654–41,821,817, 164 basesExon 10: 41,822,223–41,823,213, 991 bases123456789105′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.6 kb of the gene's 10.2 kb; 1,749 of those bases code for the protein.

How a genome test reads FKBP10

47

positions in FKBP10 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 10.2 kb of FKBP10, introns included, not only the 2.6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). FKBP10 gene: FKBP prolyl isomerase 10. Retrieved 17 October 2026, from https://dantelabs.com/genes/fkbp10

Vancouver

Dante Labs. FKBP10 gene: FKBP prolyl isomerase 10 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/fkbp10

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