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Gene

SPRED2

sprouty related EVH1 domain containing 2

Summary

Cytogenetic location
2p14
Coordinates
Chromosome 2: 65,310,851–65,432,599 (GRCh38)
Exons
6 exons across 121.7 kb
Protein
418 amino acids
Inheritance
Autosomal dominant
Also known as
Spred-2, FLJ21897, FLJ31917
MANE Select transcript
ENST00000356388.9NM_181784.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Noonan Syndrome

    • Autosomal dominant

      Noonan Syndrome (NS) is characterized by short stature, typical facial dysmorphism and congenital heart defects.

      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Cardiac surveillance, developmental support, growth hormone therapy, genetic counseling, MEK inhibitor trials

    • Noonan Syndrome and Noonan-Related Syndromes

      A group of RAS pathway conditions, including Noonan, Costello, cardiofaciocutaneous and Legius syndromes, with variable heart defects, short stature and distinctive facial features.

      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Knowing about it supports heart, growth and developmental assessment.

Broader groupings

  • Hypertrophic Cardiomyopathy

    • Autosomal dominant

      One of 62 genes linked to it

      A condition in which the myocardium is hypertrophied without an obvious cause. The hypertrophy is generally asymmetric and may be associated with obstruction of the ventricular outflow tract.

      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Beta-blockers, non-dihydropyridine calcium channel blockers, activity restriction, genetic counseling

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How SPRED2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 2, with a bracket where SPRED2 sits. SPRED2 and 4 genes near it on chromosome 2, from 64,871,725 to 65,871,724.Chromosome 22p14p25.3p25.2p25.1p24.3p24.2p24.1p23.3p23.2p23.1p22.3p22.2p22.1p21p16.3p16.2p16.1p15p14p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13q14.1q14.2q14.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q34q35q36.1q36.2q36.3q37.1q37.2q37.365 Mb65.2 Mb65.4 Mb65.6 Mb65.8 MbSLC1A4: 64,988,477–65,023,865, forward strandSLC1A4CEP68: 65,056,350–65,087,298, forward strandCEP68RAB1A: 65,070,696–65,130,986, reverse strandRAB1AACTR2: 65,227,714–65,271,253, forward strandACTR2SPRED2: 65,310,851–65,432,599, reverse strandSPRED2Diagram of SPRED2: 6 exons on the reverse strand of chromosome 2Exon 6: 1 known disease-causing siteExon 3: 1 known disease-causing siteExon 2: 2 known disease-causing sitesExon 6: 65,310,851–65,314,169, 3,319 basesExon 5: 65,316,734–65,316,883, 150 basesExon 4: 65,331,987–65,332,051, 65 basesExon 3: 65,334,605–65,334,773, 169 basesExon 2: 65,344,719–65,344,896, 178 basesExon 1: 65,431,962–65,432,599, 638 bases6543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.5 kb of the gene's 121.7 kb; 1,257 of those bases code for the protein.

How a genome test reads SPRED2

4

positions in SPRED2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 121.7 kb of SPRED2, introns included, not only the 4.5 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). SPRED2 gene: sprouty related EVH1 domain containing 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/spred2

Vancouver

Dante Labs. SPRED2 gene: sprouty related EVH1 domain containing 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/spred2

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