Gene
TNFRSF11A
TNF receptor superfamily member 11a
- HGNC 11908(opens in a new tab)
- Ensembl gene ENSG00000141655(opens in a new tab)
- NCBI Gene 8792(opens in a new tab)
Summary
- Cytogenetic location
- 18q21.33
- Coordinates
- Chromosome 18: 62,325,310–62,391,288 (GRCh38)
- Exons
- 10 exons across 66 kb
- Protein
- 616 amino acids
- Inheritance
- Autosomal dominant
- Also known as
- RANK, CD265, FEO, ODFR, TRANCE-R
- Previous symbols
- PDB2, LOH18CR1
- MANE Select transcript
- ENST00000586569.3NM_003839.4
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Familial Paget Disease of Bone
- Early-onset Paget disease of bone (TNFRSF11A-related)Autosomal dominant
A form of Paget disease with onset in early adulthood, often with hearing loss and early tooth loss, caused by TNFRSF11A variants.
- 1 GenCC submitter rates it definitive or strong
Osteopetrosis
Osteopetrosis, also known as marble bone disease, is a descriptive term that refers to a group of rare, heritable disorders of the skeleton characterized by increased bone density on radiographs.
- 4 GenCC submitters rate it definitive or strong
Inheritance
- Autosomal dominant
- One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.
How TNFRSF11A is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 8.1 kb of the gene's 66 kb; 1,851 of those bases code for the protein.
How a genome test reads TNFRSF11A
12
positions in TNFRSF11A where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
A whole genome covers all 66 kb of TNFRSF11A, introns included, not only the 8.1 kb of exons.
Traits linked to TNFRSF11A
The Human Phenotype Ontology lists these as features of the rare conditions TNFRSF11A can cause. Each trait's page lists the other genes linked to it.
Abnormality of the musculoskeletal system
- Harder, denser, fracture-prone bones
- Increased susceptibility to fractures
- Sandwich appearance of vertebral bodies
- Abnormal collarbone
- Abnormal deposits of calcium in the brain
- Flattened vertebrae
- Increased bone mineral density
- Irregular vertebral endplates
Show 13 more traits
Abnormality of head or neck
- Dense bone of skull base
- Abnormal dentition
- Abnormal tooth enamel
- Big calvaria
- Delayed eruption of teeth
- Enlargement of craniofacial bones
- Enlargement of skull bones
- Increased head circumference
Show 2 more traits
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
- The ACMG secondary findings list, SF v3.2.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). TNFRSF11A gene: TNF receptor superfamily member 11a. Retrieved 17 October 2026, from https://dantelabs.com/genes/tnfrsf11a
Dante Labs. TNFRSF11A gene: TNF receptor superfamily member 11a [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/tnfrsf11a
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