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Gene

PPARG

peroxisome proliferator activated receptor gamma

Summary

Cytogenetic location
3p25.2
Coordinates
Chromosome 3: 12,289,070–12,434,344 (GRCh38)
Exons
8 exons across 145.3 kb
Protein
475 amino acids
Also known as
PPARG1, PPARG2, NR1C3, PPARgamma
MANE Select transcript
ENST00000651735.1NM_138711.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Lipodystrophy

    • Familial Partial Lipodystrophy

      Includes the LMNA (Dunnigan), PPARG, PLIN1, LIPE, AKT2, CAV1 and PLAAT3 forms, which cause loss of fat from the limbs and buttocks with insulin resistance, diabetes, high triglycerides and fatty liver.

      • 5 GenCC submitters rate it definitive or strong
      What knowing changes

      Knowing allows early screening and treatment of diabetes, triglycerides and liver disease, and in selected cases metreleptin.

How PPARG is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 3, with a bracket where PPARG sits. PPARG and 10 genes near it on chromosome 3, from 11,861,707 to 12,861,706.Chromosome 33p25.2p26.3p26.2p26.1p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13.11q13.12q13.13q13.2q13.31q13.32q13.33q21.1q21.2q21.3q22.1q22.2q22.3q23q24q25.1q25.2q25.31q25.32q25.33q26.1q26.2q26.31q26.32q26.33q27.1q27.2q27.3q28q2912 Mb12.2 Mb12.4 Mb12.6 Mb12.8 MbSYN2: 12,004,325–12,192,032, forward strandSYN2TIMP4: 12,149,834–12,159,395, reverse strandTIMP4PPARG: 12,289,070–12,434,344, forward strandPPARGTSEN2: 12,480,529–12,541,549, forward strandTSEN2MKRN2OS: 12,514,934–12,561,059, reverse strandMKRN2OSMKRN2: 12,557,011–12,603,555, forward strandMKRN2RAF1: 12,582,101–12,664,201, reverse strandRAF1TMEM40: 12,733,528–12,769,457, reverse strandTMEM40CAND2: 12,796,472–12,836,433, forward strandCAND2: 12,825,768–12,871,919, forward strandRPL32: 12,834,467–12,841,587, reverse strandRPL32Diagram of PPARG: 8 exons on the forward strand of chromosome 3Exon 3: 1 known disease-causing siteExon 4: 5 known disease-causing sitesExon 5: 1 known disease-causing siteExon 6: 5 known disease-causing sitesExon 7: 4 known disease-causing sitesExon 8: 4 known disease-causing sitesExon 1: 12,289,070–12,289,134, 65 basesExon 2: 12,312,380–12,312,453, 74 basesExon 3: 12,379,704–12,379,931, 228 basesExon 4: 12,381,322–12,381,491, 170 basesExon 5: 12,392,614–12,392,752, 139 basesExon 6: 12,405,882–12,406,081, 200 basesExon 7: 12,416,704–12,417,154, 451 basesExon 8: 12,433,898–12,434,344, 447 bases124685′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.8 kb of the gene's 145.3 kb; 1,428 of those bases code for the protein.

How a genome test reads PPARG

23

positions in PPARG where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 145.3 kb of PPARG, introns included, not only the 1.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). PPARG gene: peroxisome proliferator activated receptor gamma. Retrieved 17 October 2026, from https://dantelabs.com/genes/pparg

Vancouver

Dante Labs. PPARG gene: peroxisome proliferator activated receptor gamma [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/pparg

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