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Gene

KY

kyphoscoliosis peptidase

Summary

Cytogenetic location
3q22.2
Coordinates
Chromosome 3: 134,599,923–134,651,022 (GRCh38)
Exons
11 exons across 51.1 kb
Protein
661 amino acids
Also known as
FLJ33207
MANE Select transcript
ENST00000423778.7NM_178554.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Myofibrillar Myopathies

    • Myofibrillar myopathy

      A group of muscle disorders in which the contractile structure of muscle fibers breaks down, caused by genes such as DES, CRYAB, MYOT, LDB3, FLNC and BAG3.

      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      Because the heart is often involved, regular heart checks (such as ECG and echocardiography) are recommended even without symptoms.

How KY is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 3, with a bracket where KY sits. KY and 5 genes near it on chromosome 3, from 134,125,473 to 135,125,472.Chromosome 33q22.2p26.3p26.2p26.1p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13.11q13.12q13.13q13.2q13.31q13.32q13.33q21.1q21.2q21.3q22.1q22.2q22.3q23q24q25.1q25.2q25.31q25.32q25.33q26.1q26.2q26.31q26.32q26.33q27.1q27.2q27.3q28q29134.2 Mb134.4 Mb134.6 Mb134.8 Mb135 MbRYK: 134,065,303–134,250,929, reverse strandRYKAMOTL2: 134,355,347–134,375,479, reverse strandAMOTL2ANAPC13: 134,476,251–134,486,716, reverse strandANAPC13CEP63: 134,485,699–134,587,789, forward strandCEP63KY: 134,599,923–134,651,022, reverse strandKYEPHB1: 134,795,252–135,260,467, forward strandEPHB1Diagram of KY: 11 exons on the reverse strand of chromosome 3Exon 8: 1 known disease-causing siteExon 6: 2 known disease-causing sitesExon 1: 2 known disease-causing sitesExon 11: 134,599,923–134,604,474, 4,552 basesExon 10: 134,608,649–134,608,839, 191 basesExon 9: 134,610,195–134,610,383, 189 basesExon 8: 134,619,148–134,619,265, 118 basesExon 7: 134,620,749–134,620,857, 109 basesExon 6: 134,625,053–134,625,135, 83 basesExon 5: 134,627,756–134,627,818, 63 basesExon 4: 134,629,621–134,629,695, 75 basesExon 3: 134,643,316–134,643,378, 63 basesExon 2: 134,647,435–134,647,497, 63 basesExon 1: 134,650,825–134,651,022, 198 bases11109876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.7 kb of the gene's 51.1 kb; 1,986 of those bases code for the protein.

How a genome test reads KY

5

positions in KY where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 51.1 kb of KY, introns included, not only the 5.7 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). KY gene: kyphoscoliosis peptidase. Retrieved 16 October 2026, from https://dantelabs.com/genes/ky

Vancouver

Dante Labs. KY gene: kyphoscoliosis peptidase [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/ky

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