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Gene

OBSCN

obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF

Summary

Cytogenetic location
1q42.13
Coordinates
Chromosome 1: 228,208,044–228,378,876 (GRCh38)
Exons
116 exons across 170.8 kb
Protein
8,925 amino acids
Also known as
KIAA1556, UNC89, KIAA1639, ARHGEF30
MANE Select transcript
ENST00000680850.1NM_001386125.1
Locus type
gene with protein product

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads OBSCN yet. The test sequences your whole genome, so your data includes it all the same.

How OBSCN is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where OBSCN sits. OBSCN and 16 genes near it on chromosome 1, from 227,793,460 to 228,793,459.Chromosome 11q42.13p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44227.8 Mb228 Mb228.2 Mb228.4 Mb228.6 MbPRSS38: 227,815,675–227,846,478, forward strandPRSS38WNT9A: 227,918,656–227,947,939, reverse strandWNT9AWNT3A: 228,006,924–228,061,328, forward strandWNT3AARF1: 228,081,841–228,099,212, forward strandARF1C1orf35: 228,099,030–228,105,411, reverse strandC1orf35MRPL55: 228,105,949–228,109,358, reverse strandMRPL55GUK1: 228,139,962–228,148,984, forward strandGUK1GJC2: 228,149,891–228,159,826, forward strandGJC2IBA57: 228,165,777–228,182,257, forward strandIBA57OBSCN: 228,208,044–228,378,876, forward strandOBSCNTRIM11: 228,393,672–228,406,841, reverse strandTRIM11TRIM17: 228,406,860–228,416,902, reverse strandTRIM17H3-4: 228,424,845–228,425,360, reverse strandH3-4H2AC25: 228,434,777–228,457,873, reverse strandH2AC25H2BC26: 228,458,103–228,463,104, forward strandRNF187: 228,487,357–228,499,899, forward strandRNF187RHOU: 228,735,147–228,746,669, forward strandRHOUDiagram of OBSCN: 116 exons on the forward strand of chromosome 1Exon 19: 1 known disease-causing siteExon 20: 1 known disease-causing siteExon 26: 1 known disease-causing siteExon 30: 1 known disease-causing siteExon 33: 1 known disease-causing siteExon 48: 1 known disease-causing siteExon 50: 1 known disease-causing siteExon 57: 1 known disease-causing siteExon 61: 1 known disease-causing siteExon 70: 1 known disease-causing siteExon 77: 1 known disease-causing siteExon 82: 1 known disease-causing siteExon 85: 1 known disease-causing siteExon 105: 3 known disease-causing sitesExon 111: 1 known disease-causing siteExon 1: 228,208,044–228,208,185, 142 basesExon 2: 228,211,766–228,212,771, 1,006 basesExon 3: 228,213,441–228,213,710, 270 basesExon 4: 228,214,174–228,214,434, 261 basesExon 5: 228,214,790–228,215,098, 309 basesExon 6: 228,215,563–228,215,829, 267 basesExon 7: 228,216,421–228,216,702, 282 basesExon 8: 228,217,013–228,217,288, 276 basesExon 9: 228,219,324–228,219,599, 276 basesExon 10: 228,224,459–228,224,734, 276 basesExon 11: 228,243,183–228,243,458, 276 basesExon 12: 228,244,296–228,244,571, 276 basesExon 13: 228,245,413–228,245,688, 276 basesExon 14: 228,246,528–228,246,803, 276 basesExon 15: 228,249,965–228,250,240, 276 basesExon 16: 228,256,651–228,256,926, 276 basesExon 17: 228,259,501–228,259,776, 276 basesExon 18: 228,264,116–228,264,391, 276 basesExon 19: 228,268,530–228,268,805, 276 basesExon 20: 228,271,925–228,272,221, 297 basesExon 21: 228,273,272–228,273,547, 276 basesExon 22: 228,273,770–228,274,048, 279 basesExon 23: 228,274,178–228,274,444, 267 basesExon 24: 228,274,572–228,274,841, 270 basesExon 25: 228,275,760–228,276,026, 267 basesExon 26: 228,276,450–228,276,716, 267 basesExon 27: 228,276,930–228,277,042, 113 basesExon 28: 228,277,160–228,277,313, 154 basesExon 29: 228,277,505–228,277,666, 162 basesExon 30: 228,277,754–228,277,858, 105 basesExon 31: 228,278,689–228,278,955, 267 basesExon 32: 228,279,175–228,279,444, 270 basesExon 33: 228,279,821–228,280,087, 267 basesExon 34: 228,280,179–228,280,445, 267 basesExon 35: 228,280,530–228,280,796, 267 basesExon 36: 228,281,933–228,282,205, 273 basesExon 37: 228,283,018–228,283,284, 267 basesExon 38: 228,283,503–228,283,769, 267 basesExon 39: 228,286,078–228,286,350, 273 basesExon 40: 228,286,773–228,287,039, 267 basesExon 41: 228,287,694–228,287,960, 267 basesExon 42: 228,288,061–228,288,324, 264 basesExon 43: 228,288,625–228,288,888, 264 basesExon 44: 228,291,898–228,292,161, 264 basesExon 45: 228,292,523–228,292,786, 264 basesExon 46: 228,293,353–228,293,616, 264 basesExon 47: 228,294,152–228,294,415, 264 basesExon 48: 228,294,780–228,295,043, 264 basesExon 49: 228,298,454–228,298,717, 264 basesExon 50: 228,299,259–228,299,522, 264 basesExon 51: 228,299,882–228,300,145, 264 basesExon 52: 228,303,675–228,303,938, 264 basesExon 53: 228,304,303–228,304,566, 264 basesExon 54: 228,305,123–228,305,386, 264 basesExon 55: 228,306,372–228,306,638, 267 basesExon 56: 228,306,901–228,307,167, 267 basesExon 57: 228,307,259–228,307,531, 273 basesExon 58: 228,308,111–228,308,383, 273 basesExon 59: 228,309,099–228,309,295, 197 basesExon 60: 228,309,484–228,309,559, 76 basesExon 61: 228,315,847–228,316,119, 273 basesExon 62: 228,316,709–228,316,984, 276 basesExon 63: 228,317,464–228,317,751, 288 basesExon 64: 228,317,892–228,318,173, 282 basesExon 65: 228,318,884–228,319,254, 371 basesExon 66: 228,321,344–228,322,214, 871 basesExon 67: 228,323,328–228,323,606, 279 basesExon 68: 228,332,860–228,332,938, 79 basesExon 69: 228,333,199–228,333,323, 125 basesExon 70: 228,333,583–228,333,780, 198 basesExon 71: 228,334,512–228,334,544, 33 basesExon 72: 228,334,815–228,334,913, 99 basesExon 73: 228,335,080–228,335,298, 219 basesExon 74: 228,335,791–228,335,851, 61 basesExon 75: 228,336,200–228,336,270, 71 basesExon 76: 228,337,004–228,337,126, 123 basesExon 77: 228,337,244–228,337,383, 140 basesExon 78: 228,337,944–228,338,144, 201 basesExon 79: 228,338,290–228,338,372, 83 basesExon 80: 228,338,853–228,339,026, 174 basesExon 81: 228,339,945–228,340,101, 157 basesExon 82: 228,340,506–228,340,622, 117 basesExon 83: 228,340,724–228,340,888, 165 basesExon 84: 228,341,095–228,341,253, 159 basesExon 85: 228,341,437–228,341,614, 178 basesExon 86: 228,342,119–228,342,232, 114 basesExon 87: 228,349,890–228,350,057, 168 basesExon 88: 228,350,841–228,350,943, 103 basesExon 89: 228,351,321–228,351,450, 130 basesExon 90: 228,352,951–228,353,062, 112 basesExon 91: 228,362,576–228,362,755, 180 basesExon 92: 228,364,981–228,365,077, 97 basesExon 93: 228,365,436–228,365,560, 125 basesExon 94: 228,366,074–228,366,186, 113 basesExon 95: 228,366,400–228,366,568, 169 basesExon 96: 228,366,808–228,366,889, 82 basesExon 97: 228,366,975–228,367,175, 201 basesExon 98: 228,367,886–228,367,946, 61 basesExon 99: 228,368,339–228,368,416, 78 basesExon 100: 228,368,722–228,368,894, 173 basesExon 101: 228,369,136–228,369,162, 27 basesExon 102: 228,369,942–228,370,094, 153 basesExon 103: 228,370,193–228,370,238, 46 basesExon 104: 228,370,679–228,370,756, 78 basesExon 105: 228,371,023–228,373,081, 2,059 basesExon 106: 228,373,932–228,374,012, 81 basesExon 107: 228,374,314–228,374,424, 111 basesExon 108: 228,374,585–228,374,752, 168 basesExon 109: 228,375,702–228,375,824, 123 basesExon 110: 228,376,008–228,376,178, 171 basesExon 111: 228,376,793–228,376,874, 82 basesExon 112: 228,377,052–228,377,291, 240 basesExon 113: 228,377,489–228,377,712, 224 basesExon 114: 228,377,931–228,378,006, 76 basesExon 115: 228,378,271–228,378,420, 150 basesExon 116: 228,378,618–228,378,876, 259 bases1204060801001165′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 27 kb of the gene's 170.8 kb; 26,778 of those bases code for the protein.

How a genome test reads OBSCN

18

positions in OBSCN where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 170.8 kb of OBSCN, introns included, not only the 27 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). OBSCN gene: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF. Retrieved 17 October 2026, from https://dantelabs.com/genes/obscn

Vancouver

Dante Labs. OBSCN gene: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/obscn

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