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Gene

LRP12

LDL receptor related protein 12

Summary

Cytogenetic location
8q22.3
Coordinates
Chromosome 8: 104,489,236–104,589,258 (GRCh38)
Exons
7 exons across 100 kb
Protein
859 amino acids
Also known as
ST7, FLJ12929
MANE Select transcript
ENST00000276654.10NM_013437.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Distal Myopathies

    • Distal myopathy

      A group of inherited muscle disorders in which weakness starts in the hands, forearms, lower legs or feet, caused by genes such as TTN, DYSF, FLNC, MYH7, ADSS1, SMPX and MATR3.

      • ClinGen rates the link moderate
      • 1 GenCC submitter rates it definitive or strong

How LRP12 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 8, with a bracket where LRP12 sits. LRP12 and 4 genes near it on chromosome 8, from 104,039,247 to 105,039,246.Chromosome 88q22.3p23.3p23.2p23.1p22p21.3p21.2p21.1p12p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q12.1q12.2q12.3q13.1q13.2q13.3q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.3104.2 Mb104.4 Mb104.6 Mb104.8 Mb105 MbRIMS2: 103,499,638–104,254,698, forward strandRIMS2DPYS: 104,327,415–104,467,111, reverse strandDPYSDCSTAMP: 104,339,087–104,356,689, forward strandDCSTAMPLRP12: 104,489,236–104,589,258, reverse strandLRP12ZFPM2: 104,590,733–105,805,813, forward strandZFPM2Diagram of LRP12: 7 exons on the reverse strand of chromosome 8Exon 7: 104,489,236–104,491,539, 2,304 basesExon 6: 104,495,077–104,495,209, 133 basesExon 5: 104,496,972–104,498,076, 1,105 basesExon 4: 104,499,317–104,499,519, 203 basesExon 3: 104,508,939–104,509,074, 136 basesExon 2: 104,531,907–104,531,963, 57 basesExon 1: 104,588,819–104,589,258, 440 bases76543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.4 kb of the gene's 100 kb; 2,580 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). LRP12 gene: LDL receptor related protein 12. Retrieved 17 October 2026, from https://dantelabs.com/genes/lrp12

Vancouver

Dante Labs. LRP12 gene: LDL receptor related protein 12 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/lrp12

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