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Gene

ORAI1

ORAI calcium release-activated calcium modulator 1

Summary

Cytogenetic location
12q24.31
Also known as
FLJ14466, CRACM1
Previous symbols
TMEM142A
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Other Inborn Errors of Immunity

      • Immunodeficiency Disease

        One of 170 genes linked to it

        Disease in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.

        • 2 GenCC submitters rate it definitive or strong
        What knowing changes

        HSCT for SCID and severe PIDs; immunoglobulin replacement (IVIG/SCIG) for antibody deficiencies; leniolisib (Joenja, FDA 2023) for APDS; gene therapy for ADA-SCID; abatacept for CTLA4/LRBA deficiency; prophylactic antibiotics; G-CSF for CGD

    How a genome test reads ORAI1

    18

    positions in ORAI1 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). ORAI1 gene: ORAI calcium release-activated calcium modulator 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/orai1

    Vancouver

    Dante Labs. ORAI1 gene: ORAI calcium release-activated calcium modulator 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/orai1

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