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Trait

Barrel-shaped chest

A rounded, bulging chest that resembles the shape of a barrel. That is, there is an increased anteroposterior diameter and usually some degree of kyphosis.

HPO HP:0001552

Summary

Also called
Barrel chest
Body system
Abnormality of the musculoskeletal system

18 condition reports read genes linked to this trait

Dante Labs condition reports look at the genes behind groups of inherited conditions, read from one whole-genome test. Each page says which conditions and genes a report covers, how it is read and what it cannot tell you.

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23 genes linked to Barrel-shaped chest

Changes in these genes cause rare conditions in which Barrel-shaped chest is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
ACANaggrecanAlwaysIn 2 conditions
DYMdymeclinAlwaysIn 2 conditions
LBRlamin B receptorAlwaysIn 1 condition
RMRPRNA component of mitochondrial RNA processing endoribonucleaseAlwaysIn 1 condition
TRAPPC2trafficking protein particle complex subunit 2AlwaysIn 2 conditions
CHST3carbohydrate sulfotransferase 3Very often (80–99%)In 2 conditions
ACP5acid phosphatase 5, tartrate resistantOften (30–79%)In 1 condition
COL13A1collagen type XIII alpha 1 chainOften (30–79%)In 1 condition
KDELR2KDEL endoplasmic reticulum protein retention receptor 2Often (30–79%)In 1 condition
WNT7AWnt family member 7AOften (30–79%)In 1 condition
CILK1ciliogenesis associated kinase 1Sometimes (5–29%)In 1 condition
COL2A1collagen type II alpha 1 chainSometimes (5–29%)In 4 conditions
P3H1prolyl 3-hydroxylase 1Sometimes (5–29%)In 1 condition
VPS33AVPS33A core subunit of CORVET and HOPS complexesSometimes (5–29%)In 1 condition
MYH3myosin heavy chain 3Rarely (1–4%)In 1 condition
EIF2AK3eukaryotic translation initiation factor 2 alpha kinase 3Not recordedIn 1 condition
FUCA1alpha-L-fucosidase 1Not recordedIn 1 condition
HRASHRas proto-oncogene, GTPaseNot recordedIn 1 condition
LRP5LDL receptor related protein 5Not recordedIn 1 condition
RAB33BRAB33B, member RAS oncogene familyNot recordedIn 1 condition
TNFRSF11BTNF receptor superfamily member 11bNot recordedIn 1 condition
TRIP11thyroid hormone receptor interactor 11Not recordedIn 1 condition
TRPV4transient receptor potential cation channel subfamily V member 4Not recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Wide rib cage

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.17-8666dff2.

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