Trait
Persistent pupillary membrane
The presence of remnants of a fetal membrane that persist as strands of tissue crossing the pupil.
Summary
- Body system
- Abnormality of the eye
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Persistent pupillary membrane, and the rest of your genome, with one test.
From $449Free shipping · Results in 6–8 weeks
Get my Genome Test12 genes linked to Persistent pupillary membrane
Changes in these genes cause rare conditions in which Persistent pupillary membrane is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| HYAL2hyaluronidase 2 | Always | In 1 condition |
| ATOH7atonal bHLH transcription factor 7 | Often (30–79%) | In 2 conditions |
| FZD4frizzled class receptor 4 | Often (30–79%) | In 1 condition |
| GJA1gap junction protein alpha 1 | Often (30–79%) | In 1 condition |
| NDPnorrin cystine knot growth factor NDP | Often (30–79%) | In 1 condition |
| OTX2orthodenticle homeobox 2 | Often (30–79%) | In 1 condition |
| POMT2protein O-mannosyltransferase 2 | Often (30–79%) | In 1 condition |
| ADAMTSL4ADAMTS like 4 | Sometimes (5–29%) | In 1 condition |
| COL18A1collagen type XVIII alpha 1 chain | Sometimes (5–29%) | In 1 condition |
| CPAMD8C3 and PZP like alpha-2-macroglobulin domain containing 8 | Sometimes (5–29%) | In 1 condition |
| HRASHRas proto-oncogene, GTPase | Sometimes (5–29%) | In 1 condition |
| TRPM3transient receptor potential cation channel subfamily M member 3 | Sometimes (5–29%) | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
One test. A lifetime of answers.
From $449Free shipping · Results in 6–8 weeks