Trait
Loose redundant skin
Clinical name: Redundant skin
Loose and sagging skin often associated with loss of skin elasticity.
Summary
- Also called
- Redundant skin folds, Sagging, redundant skin
- Body system
- Abnormality of the integument
Reference genomeGRCh38hg38
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Get my Genome Test67 genes linked to Loose redundant skin
Changes in these genes cause rare conditions in which Loose redundant skin is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| AEBP1AE binding protein 1 | Always | In 2 conditions |
| ATP6V0A2ATPase H+ transporting V0 subunit a2 | Always | In 3 conditions |
| ATP6V1AATPase H+ transporting V1 subunit A | Always | In 2 conditions |
| ELNelastin | Always | In 3 conditions |
| FBLN5fibulin 5 | Always | In 3 conditions |
| FGF20fibroblast growth factor 20 | Always | In 1 condition |
| GGCXgamma-glutamyl carboxylase | Always | In 3 conditions |
| NDUFB11NADH:ubiquinone oxidoreductase subunit B11 | Always | In 1 condition |
| RIN2Ras and Rab interactor 2 | Always | In 2 conditions |
| ALDH18A1aldehyde dehydrogenase 18 family member A1 | Very often (80–99%) | In 1 condition |
| ATP6V1E1ATPase H+ transporting V1 subunit E1 | Very often (80–99%) | In 1 condition |
| EFEMP2EGF-like fibulin extracellular matrix protein 2 | Very often (80–99%) | In 1 condition |
| EZH2enhancer of zeste 2 polycomb repressive complex 2 subunit | Very often (80–99%) | In 1 condition |
| FGFR3fibroblast growth factor receptor 3 | Very often (80–99%) | In 3 conditions |
| GORABgolgin, RAB6 interacting | Very often (80–99%) | In 1 condition |
| HRASHRas proto-oncogene, GTPase | Very often (80–99%) | In 1 condition |
| LTBP1latent transforming growth factor beta binding protein 1 | Very often (80–99%) | In 1 condition |
| NSD1nuclear receptor binding SET domain protein 1 | Very often (80–99%) | In 1 condition |
| PTDSS1phosphatidylserine synthase 1 | Very often (80–99%) | In 1 condition |
| PYCR1pyrroline-5-carboxylate reductase 1 | Very often (80–99%) | In 2 conditions |
| SLC25A24solute carrier family 25 member 24 | Very often (80–99%) | In 2 conditions |
| SUZ12SUZ12 polycomb repressive complex 2 subunit | Very often (80–99%) | In 1 condition |
| TWIST2twist family bHLH transcription factor 2 | Very often (80–99%) | In 5 conditions |
| ABCC6ATP binding cassette subfamily C member 6 | Often (30–79%) | In 1 condition |
| ADAMTS2ADAM metallopeptidase with thrombospondin type 1 motif 2 | Often (30–79%) | In 1 condition |
| BAZ1Bbromodomain adjacent to zinc finger domain 1B | Often (30–79%) | In 1 condition |
| BUD23BUD23 rRNA methyltransferase and ribosome maturation factor | Often (30–79%) | In 1 condition |
| CD96CD96 molecule | Often (30–79%) | In 1 condition |
| CHST14carbohydrate sulfotransferase 14 | Often (30–79%) | In 1 condition |
| CLIP2CAP-Gly domain containing linker protein 2 | Often (30–79%) | In 1 condition |
| DNAJC30DnaJ heat shock protein family (Hsp40) member C30 | Often (30–79%) | In 1 condition |
| DSEdermatan sulfate epimerase | Often (30–79%) | In 1 condition |
| EIF4Heukaryotic translation initiation factor 4H | Often (30–79%) | In 1 condition |
| ENPP1ectonucleotide pyrophosphatase/phosphodiesterase 1 | Often (30–79%) | In 1 condition |
| EXT1exostosin glycosyltransferase 1 | Often (30–79%) | In 1 condition |
| FKBP6FKBP prolyl isomerase family member 6 (inactive) | Often (30–79%) | In 1 condition |
| GTF2Igeneral transcription factor IIi | Often (30–79%) | In 1 condition |
| GTF2IRD1GTF2I repeat domain containing 1 | Often (30–79%) | In 1 condition |
| GTF2IRD2GTF2I repeat domain containing 2 | Often (30–79%) | In 1 condition |
| LIMK1LIM domain kinase 1 | Often (30–79%) | In 1 condition |
Show 27 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| LTBP4latent transforming growth factor beta binding protein 4 | Often (30–79%) | In 1 condition |
| METTL27methyltransferase like 27 | Often (30–79%) | In 1 condition |
| NCF1neutrophil cytosolic factor 1 | Often (30–79%) | In 1 condition |
| RAD21RAD21 cohesin complex component | Often (30–79%) | In 1 condition |
| RFC2replication factor C subunit 2 | Often (30–79%) | In 1 condition |
| RPS6KA3ribosomal protein S6 kinase A3 | Often (30–79%) | In 1 condition |
| STX1Asyntaxin 1A | Often (30–79%) | In 1 condition |
| TBL2transducin beta like 2 | Often (30–79%) | In 1 condition |
| TMEM270transmembrane protein 270 | Often (30–79%) | In 1 condition |
| TRPS1transcriptional repressor GATA binding 1 | Often (30–79%) | In 1 condition |
| VPS37DVPS37D subunit of ESCRT-I | Often (30–79%) | In 1 condition |
| ALG12ALG12 alpha-1,6-mannosyltransferase | Sometimes (5–29%) | In 1 condition |
| BRAFB-Raf proto-oncogene, serine/threonine kinase | Sometimes (5–29%) | In 1 condition |
| COL3A1collagen type III alpha 1 chain | Sometimes (5–29%) | In 1 condition |
| FOXC1forkhead box C1 | Sometimes (5–29%) | In 1 condition |
| H1-4H1.4 linker histone, cluster member | Sometimes (5–29%) | In 1 condition |
| KRASKRas proto-oncogene, GTPase | Sometimes (5–29%) | In 2 conditions |
| MAP2K1mitogen-activated protein kinase kinase 1 | Sometimes (5–29%) | In 1 condition |
| MAP2K2mitogen-activated protein kinase kinase 2 | Sometimes (5–29%) | In 1 condition |
| PITX2paired like homeodomain 2 | Sometimes (5–29%) | In 1 condition |
| SLC2A10solute carrier family 2 member 10 | Sometimes (5–29%) | In 1 condition |
| SLC6A8solute carrier family 6 member 8 | Sometimes (5–29%) | In 1 condition |
| ANTXR1ANTXR cell adhesion molecule 1 | Not recorded | In 1 condition |
| ATP7AATPase copper transporting alpha | Not recorded | In 1 condition |
| GPX4glutathione peroxidase 4 | Not recorded | In 1 condition |
| HPGD15-hydroxyprostaglandin dehydrogenase | Not recorded | In 1 condition |
| NAA10N-alpha-acetyltransferase 10, NatA catalytic subunit | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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