Trait

Deep palm line

Clinical name: Deep palmar crease

Excessively deep creases of the palm.

HPO HP:0006191

Also called: Deep palmar creases
Body system: Abnormality of limbs Abnormality of the integument

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34 genes linked to Deep palm line

Changes in these genes cause rare conditions in which Deep palm line is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
MTORmechanistic target of rapamycin kinase	Always	In 1 condition
PIGAphosphatidylinositol glycan anchor biosynthesis class A	Always	In 1 condition
TBL1XR1TBL1X/Y related 1	Always	In 2 conditions
AIPAHR interacting HSP90 co-chaperone	Very often (80–99%)	In 1 condition
ATP6V0A2ATPase H+ transporting V0 subunit a2	Very often (80–99%)	In 2 conditions
GPR101G protein-coupled receptor 101	Very often (80–99%)	In 1 condition
LTBP1latent transforming growth factor beta binding protein 1	Very often (80–99%)	In 1 condition
ASXL1ASXL transcriptional regulator 1	Often (30–79%)	In 1 condition
ASXL2ASXL transcriptional regulator 2	Often (30–79%)	In 1 condition
ASXL3ASXL transcriptional regulator 3	Often (30–79%)	In 1 condition
BRAFB-Raf proto-oncogene, serine/threonine kinase	Often (30–79%)	In 3 conditions
CDK10cyclin dependent kinase 10	Often (30–79%)	In 1 condition
KRASKRas proto-oncogene, GTPase	Often (30–79%)	In 2 conditions
MAP2K1mitogen-activated protein kinase kinase 1	Often (30–79%)	In 2 conditions
MAP2K2mitogen-activated protein kinase kinase 2	Often (30–79%)	In 2 conditions
PRR12proline rich 12	Often (30–79%)	In 1 condition
SPRED2sprouty related EVH1 domain containing 2	Often (30–79%)	In 1 condition
DPYDdihydropyrimidine dehydrogenase	Sometimes (5–29%)	In 1 condition
MTX2metaxin 2	Sometimes (5–29%)	In 1 condition
OTUD5OTU deubiquitinase 5	Sometimes (5–29%)	In 1 condition
PGM2L1phosphoglucomutase 2 like 1	Sometimes (5–29%)	In 1 condition
SHOC2SHOC2 leucine rich repeat scaffold protein	Sometimes (5–29%)	In 1 condition
SPECC1Lsperm antigen with calponin homology and coiled-coil domains 1 like	Sometimes (5–29%)	In 1 condition
VPS33AVPS33A core subunit of CORVET and HOPS complexes	Sometimes (5–29%)	In 1 condition
WDR83OSWD repeat domain 83 opposite strand	Sometimes (5–29%)	In 1 condition
ZFXzinc finger protein X-linked	Sometimes (5–29%)	In 1 condition
ATP6V1B2ATPase H+ transporting V1 subunit B2	Rarely (1–4%)	In 1 condition
KCNH1potassium voltage-gated channel subfamily H member 1	Rarely (1–4%)	In 1 condition
KCNN3potassium calcium-activated channel subfamily N member 3	Rarely (1–4%)	In 1 condition
RNU4-2RNA, U4 small nuclear 2	Rarely (1–4%)	In 1 condition
HNRNPKheterogeneous nuclear ribonucleoprotein K	Not recorded	In 1 condition
HRASHRas proto-oncogene, GTPase	Not recorded	In 1 condition
RBM10RNA binding motif protein 10	Not recorded	In 1 condition
SLC25A24solute carrier family 25 member 24	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormality of the palm lines

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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