Trait
Spoon-shaped nails
Clinical name: Concave nail
The natural longitudinal (posterodistal) convex arch is not present or is inverted.
Summary
- Also called
- Koilonychia
- Body system
- Abnormality of the integument
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test20 genes linked to Spoon-shaped nails
Changes in these genes cause rare conditions in which Spoon-shaped nails is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| MSX1msh homeobox 1 | Always | In 1 condition |
| HRASHRas proto-oncogene, GTPase | Very often (80–99%) | In 2 conditions |
| RLIMring finger protein, LIM domain interacting | Often (30–79%) | In 1 condition |
| AARS1alanyl-tRNA synthetase 1 | Sometimes (5–29%) | In 1 condition |
| CARS1cysteinyl-tRNA synthetase 1 | Sometimes (5–29%) | In 1 condition |
| DBR1debranching RNA lariats 1 | Sometimes (5–29%) | In 1 condition |
| ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit | Sometimes (5–29%) | In 1 condition |
| ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit | Sometimes (5–29%) | In 1 condition |
| GTF2E2general transcription factor IIE subunit 2 | Sometimes (5–29%) | In 1 condition |
| GTF2H5general transcription factor IIH subunit 5 | Sometimes (5–29%) | In 1 condition |
| KRT1keratin 1 | Sometimes (5–29%) | In 1 condition |
| MPLKIPM-phase specific PLK1 interacting protein | Sometimes (5–29%) | In 2 conditions |
| RNF113Aring finger protein 113A | Sometimes (5–29%) | In 1 condition |
| TARS1threonyl-tRNA synthetase 1 | Sometimes (5–29%) | In 1 condition |
| TMPRSS6transmembrane serine protease 6 | Rarely (1–4%) | In 1 condition |
| EDAectodysplasin A | Not recorded | In 1 condition |
| HOXC13homeobox C13 | Not recorded | In 1 condition |
| LMX1BLIM homeobox transcription factor 1 beta | Not recorded | In 1 condition |
| PLCD1phospholipase C delta 1 | Not recorded | In 1 condition |
| TRPS1transcriptional repressor GATA binding 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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