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Trait

Thin nail

Nail that appears thin when viewed on end.

HPO HP:0001816

Summary

Also called
Thin nails
Body system
Abnormality of the integument

16 genes linked to Thin nail

Changes in these genes cause rare conditions in which Thin nail is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
EZH2enhancer of zeste 2 polycomb repressive complex 2 subunitAlwaysIn 2 conditions
IFT140intraflagellar transport 140AlwaysIn 1 condition
PTBP1polypyrimidine tract binding protein 1AlwaysIn 1 condition
NSD1nuclear receptor binding SET domain protein 1Very often (80–99%)In 1 condition
SUZ12SUZ12 polycomb repressive complex 2 subunitVery often (80–99%)In 1 condition
ITPR3inositol 1,4,5-trisphosphate receptor type 3Often (30–79%)In 1 condition
WNT10AWnt family member 10AOften (30–79%)In 2 conditions
ALOX12Barachidonate 12-lipoxygenase, 12R typeSometimes (5–29%)In 1 condition
ALOXE3arachidonate epidermal lipoxygenase 3Sometimes (5–29%)In 1 condition
ANAPC1anaphase promoting complex subunit 1Sometimes (5–29%)In 1 condition
CAMK2Bcalcium/calmodulin dependent protein kinase II betaSometimes (5–29%)In 1 condition
RNU4-2RNA, U4 small nuclear 2Sometimes (5–29%)In 1 condition
EEDembryonic ectoderm developmentNot recordedIn 1 condition
HRASHRas proto-oncogene, GTPaseNot recordedIn 1 condition
IFT122intraflagellar transport 122Not recordedIn 1 condition
TRPS1transcriptional repressor GATA binding 1Not recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

Broader traits

Abnormality of the nail

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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