Skip to content
Use your HSA or FSA funds

Trait

Pheochromocytoma

Pheochromocytomas (also known as chromaffin tumors) produce, store, and secrete catecholamines. Pheochromocytomas usually originate from the adrenal medulla but may also develop from chromaffin cells in or about sympathetic ganglia. A common symptom of pheochromocytoma is hypertension owing to release of catecholamines.

HPO HP:0002666

Summary

Also called
Chromaffin tumors, Chromaffin tumours
Body system
Abnormality of the endocrine systemAbnormality of the nervous systemAbnormal tissue mass

19 genes linked to Pheochromocytoma

Changes in these genes cause rare conditions in which Pheochromocytoma is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
NF1neurofibromin 1AlwaysIn 2 conditions
SDHAsuccinate dehydrogenase complex flavoprotein subunit AVery often (80–99%)In 1 condition
SDHBsuccinate dehydrogenase complex iron sulfur subunit BVery often (80–99%)In 1 condition
SDHCsuccinate dehydrogenase complex subunit CVery often (80–99%)In 1 condition
DLSTdihydrolipoamide S-succinyltransferaseOften (30–79%)In 1 condition
RETret proto-oncogeneOften (30–79%)In 3 conditions
CDKN1Bcyclin dependent kinase inhibitor 1BRarely (1–4%)In 1 condition
CDKN2Bcyclin dependent kinase inhibitor 2BRarely (1–4%)In 1 condition
HRASHRas proto-oncogene, GTPaseRarely (1–4%)In 1 condition
IFNGinterferon gammaRarely (1–4%)In 1 condition
MEN1menin 1Rarely (1–4%)In 1 condition
TSC1TSC complex subunit 1Rarely (1–4%)In 1 condition
TSC2TSC complex subunit 2Rarely (1–4%)In 1 condition
CCND1cyclin D1Not recordedIn 1 condition
KIF1Bkinesin family member 1BNot recordedIn 1 condition
MAXMYC associated transcriptional regulator XNot recordedIn 1 condition
PRKAR1Aprotein kinase cAMP-dependent type I regulatory subunit alphaNot recordedIn 1 condition
TMEM127transmembrane protein 127Not recordedIn 1 condition
VHLvon Hippel-Lindau tumor suppressorNot recordedIn 2 conditions

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

Broader traits

Neuroendocrine neoplasm

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test