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Gene

IFITM5

interferon induced transmembrane protein 5

Summary

Cytogenetic location
11p15.5
Coordinates
Chromosome 11: 298,200–299,526 (GRCh38)
Exons
2 exons across 1.3 kb
Protein
132 amino acids
Also known as
fragilis4, Hrmp1, BRIL, DSPA1
MANE Select transcript
ENST00000382614.2NM_001025295.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Osteogenesis Imperfecta

    • A group of inherited connective tissue disorders causing fragile bones that break easily, often with blue sclerae, hearing loss and dental problems.

      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Cyclic IV bisphosphonates (pamidronate, zoledronate); orthopedic rodding of long bones; physical therapy; denosumab (in clinical use for pediatric OI); romosozumab (in development); hearing monitoring; dental management for dentinogenesis imperfecta

How IFITM5 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 11, with a bracket where IFITM5 sits. IFITM5 and 35 genes near it on chromosome 11, from 1 to 798,862.Chromosome 1111p15.5p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q250.1 Mb0.2 Mb0.3 Mb0.4 Mb0.5 Mb0.6 Mb0.7 MbBET1L: 167,784–208,695, reverse strandSCGB1C1: 193,078–194,575, forward strandCIMAP1A: 196,761–200,261, forward strandCIMAP1ARIC8A: 207,478–215,164, forward strandRIC8ASIRT3: 215,026–236,931, reverse strandSIRT3PSMD13: 236,948–252,986, forward strandPSMD13NLRP6: 278,407–286,691, forward strandNLRP6PGGHG: 289,078–297,510, forward strandPGGHGIFITM5: 298,200–299,526, reverse strandIFITM5IFITM2: 303,655–309,410, forward strandIFITM2: 308,408–315,272, forward strandIFITM3: 309,010–329,475, reverse strandIFITM1: 309,997–315,275, forward strandB4GALNT4: 369,457–382,117, forward strandB4GALNT4PKP3: 392,574–404,908, forward strandPKP3SIGIRR: 405,711–417,473, reverse strandSIGIRRANO9: 417,921–442,072, reverse strandANO9PTDSS2: 448,268–501,142, forward strandPTDSS2RNH1: 494,510–507,395, reverse strandRNH1HRAS: 532,242–537,343, reverse strandHRASLRRC56: 536,841–554,925, forward strandLRRC56LMNTD2: 554,850–560,743, reverse strandLMNTD2RASSF7: 560,207–564,067, forward strandRASSF7PHRF1: 576,170–612,263, forward strandPHRF1IRF7: 612,551–615,983, reverse strandIRF7CDHR5: 616,405–626,078, reverse strandCDHR5SCT: 626,309–627,236, reverse strandSCTDRD4: 637,269–640,706, forward strandDRD4DEAF1: 644,220–707,118, reverse strandDEAF1EPS8L2: 694,438–727,729, forward strandEPS8L2TMEM80: 695,011–705,028, forward strandTMEM80TALDO1: 747,399–765,035, forward strandTALDO1GATD1: 767,061–777,507, reverse strandGATD1CEND1: 785,900–790,113, reverse strandCEND1SLC25A22: 790,474–798,321, reverse strandSLC25A22PANO1: 797,511–799,190, forward strandDiagram of IFITM5: 2 exons on the reverse strand of chromosome 11Exon 1: 2 known disease-causing sitesExon 2: 298,200–298,713, 514 basesExon 1: 299,305–299,526, 222 bases215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 0.7 kb of the gene's 1.3 kb; 399 of those bases code for the protein.

How a genome test reads IFITM5

2

positions in IFITM5 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 1.3 kb of IFITM5, introns included, not only the 0.7 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). IFITM5 gene: interferon induced transmembrane protein 5. Retrieved 16 October 2026, from https://dantelabs.com/genes/ifitm5

Vancouver

Dante Labs. IFITM5 gene: interferon induced transmembrane protein 5 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/ifitm5

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