Trait
Generalized hyperpigmentation
Summary
- Also called
- Generalised hyperpigmentation
- Body system
- Abnormality of the integument
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Generalized hyperpigmentation, and the rest of your genome, with one test.
From $449Free shipping · Results in 6–8 weeks
Get my Genome Test36 genes linked to Generalized hyperpigmentation
Changes in these genes cause rare conditions in which Generalized hyperpigmentation is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| GPNMBglycoprotein nmb | Always | In 1 condition |
| MC2Rmelanocortin 2 receptor | Always | In 2 conditions |
| OSBPL2oxysterol binding protein like 2 | Always | In 1 condition |
| AAASaladin WD repeat nucleoporin | Very often (80–99%) | In 1 condition |
| CYP11A1cytochrome P450 family 11 subfamily A member 1 | Very often (80–99%) | In 2 conditions |
| GMPPAGDP-mannose pyrophosphorylase A | Very often (80–99%) | In 1 condition |
| INSRinsulin receptor | Very often (80–99%) | In 1 condition |
| KRASKRas proto-oncogene, GTPase | Very often (80–99%) | In 2 conditions |
| MRAPmelanocortin 2 receptor accessory protein | Very often (80–99%) | In 1 condition |
| NNTnicotinamide nucleotide transhydrogenase | Very often (80–99%) | In 1 condition |
| PAX6paired box 6 | Very often (80–99%) | In 1 condition |
| STARsteroidogenic acute regulatory protein | Very often (80–99%) | In 1 condition |
| TRAPPC11trafficking protein particle complex subunit 11 | Very often (80–99%) | In 1 condition |
| TXNRD2thioredoxin reductase 2 | Very often (80–99%) | In 1 condition |
| ACDACD shelterin complex subunit and telomerase recruitment factor | Often (30–79%) | In 1 condition |
| BRAFB-Raf proto-oncogene, serine/threonine kinase | Often (30–79%) | In 1 condition |
| DKC1dyskerin pseudouridine synthase 1 | Often (30–79%) | In 1 condition |
| HAMPhepcidin antimicrobial peptide | Often (30–79%) | In 1 condition |
| HJVhemojuvelin BMP co-receptor | Often (30–79%) | In 1 condition |
| MAP2K1mitogen-activated protein kinase kinase 1 | Often (30–79%) | In 1 condition |
| MAP2K2mitogen-activated protein kinase kinase 2 | Often (30–79%) | In 1 condition |
| PARNpoly(A)-specific ribonuclease | Often (30–79%) | In 1 condition |
| RTEL1regulator of telomere elongation helicase 1 | Often (30–79%) | In 1 condition |
| TERCtelomerase RNA component | Often (30–79%) | In 1 condition |
| TERTtelomerase reverse transcriptase | Often (30–79%) | In 1 condition |
| TINF2TERF1 interacting nuclear factor 2 | Often (30–79%) | In 1 condition |
| AIPAHR interacting HSP90 co-chaperone | Sometimes (5–29%) | In 1 condition |
| AKT1AKT serine/threonine kinase 1 | Sometimes (5–29%) | In 1 condition |
| CD4CD4 molecule | Sometimes (5–29%) | In 1 condition |
| GPR101G protein-coupled receptor 101 | Sometimes (5–29%) | In 1 condition |
| HRASHRas proto-oncogene, GTPase | Sometimes (5–29%) | In 1 condition |
| IRF4interferon regulatory factor 4 | Sometimes (5–29%) | In 1 condition |
| MYO5Amyosin VA | Sometimes (5–29%) | In 1 condition |
| ATP6V1B2ATPase H+ transporting V1 subunit B2 | Rarely (1–4%) | In 1 condition |
| KCNH1potassium voltage-gated channel subfamily H member 1 | Rarely (1–4%) | In 1 condition |
| KCNN3potassium calcium-activated channel subfamily N member 3 | Rarely (1–4%) | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Narrower traits
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
One test. A lifetime of answers.
From $449Free shipping · Results in 6–8 weeks