Trait
Large earlobe
Increased volume of the earlobe, that is, abnormally prominent ear lobules.
Summary
- Also called
- Fleshy earlobe, Fleshy earlobes, Prominent ear lobes, Prominent ear lobules
- Body system
- Abnormality of the ear
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test47 genes linked to Large earlobe
Changes in these genes cause rare conditions in which Large earlobe is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| JKAMPJNK1/MAPK8 associated membrane protein | Always | In 1 condition |
| KDM6Alysine demethylase 6A | Always | In 1 condition |
| KMT2Dlysine methyltransferase 2D | Always | In 1 condition |
| TMEM94transmembrane protein 94 | Always | In 1 condition |
| TPRKBTP53RK binding protein | Always | In 1 condition |
| VPS53VPS53 subunit of GARP complex | Always | In 1 condition |
| WSB2WD repeat and SOCS box containing 2 | Always | In 1 condition |
| CDH11cadherin 11 | Very often (80–99%) | In 1 condition |
| EIF2S3eukaryotic translation initiation factor 2 subunit gamma | Very often (80–99%) | In 1 condition |
| PGAP3post-GPI attachment to proteins phospholipase 3 | Very often (80–99%) | In 1 condition |
| PGBD5piggyBac transposable element derived 5 | Very often (80–99%) | In 1 condition |
| PHF6PHD finger protein 6 | Very often (80–99%) | In 1 condition |
| SLC26A2solute carrier family 26 member 2 | Very often (80–99%) | In 1 condition |
| BRAFB-Raf proto-oncogene, serine/threonine kinase | Often (30–79%) | In 2 conditions |
| DHCR2424-dehydrocholesterol reductase | Often (30–79%) | In 1 condition |
| EFTUD2elongation factor Tu GTP binding domain containing 2 | Often (30–79%) | In 1 condition |
| ELNelastin | Often (30–79%) | In 1 condition |
| KRASKRas proto-oncogene, GTPase | Often (30–79%) | In 1 condition |
| MAP2K1mitogen-activated protein kinase kinase 1 | Often (30–79%) | In 1 condition |
| MAP2K2mitogen-activated protein kinase kinase 2 | Often (30–79%) | In 1 condition |
| MLXIPLMLX interacting protein like | Often (30–79%) | In 1 condition |
| PGM2L1phosphoglucomutase 2 like 1 | Often (30–79%) | In 1 condition |
| PHIPPHIP subunit of CUL4-Ring ligase complex | Often (30–79%) | In 1 condition |
| PIGYphosphatidylinositol glycan anchor biosynthesis class Y | Often (30–79%) | In 1 condition |
| SMOC1SPARC related modular calcium binding 1 | Often (30–79%) | In 1 condition |
| TRIP12thyroid hormone receptor interactor 12 | Often (30–79%) | In 1 condition |
| WARS1tryptophanyl-tRNA synthetase 1 | Often (30–79%) | In 1 condition |
| WDR4WDR4 tRNA N7-guanosine methyltransferase non-catalytic subunit | Often (30–79%) | In 1 condition |
| BICRABRD4 interacting chromatin remodeling complex associated protein | Sometimes (5–29%) | In 1 condition |
| BORCS8BLOC-1 related complex subunit 8 | Sometimes (5–29%) | In 1 condition |
| DOCK7dedicator of cytokinesis 7 | Sometimes (5–29%) | In 1 condition |
| DPYDdihydropyrimidine dehydrogenase | Sometimes (5–29%) | In 1 condition |
| HRASHRas proto-oncogene, GTPase | Sometimes (5–29%) | In 1 condition |
| NAV3neuron navigator 3 | Sometimes (5–29%) | In 1 condition |
| OTUD5OTU deubiquitinase 5 | Sometimes (5–29%) | In 1 condition |
| PLXNA1plexin A1 | Sometimes (5–29%) | In 1 condition |
| SPENspen family transcriptional repressor | Sometimes (5–29%) | In 1 condition |
| UFC1ubiquitin-fold modifier conjugating enzyme 1 | Sometimes (5–29%) | In 1 condition |
| ZFXzinc finger protein X-linked | Sometimes (5–29%) | In 1 condition |
| CNTNAP2contactin associated protein 2 | Rarely (1–4%) | In 1 condition |
Show 7 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| SETBP1SET binding protein 1 | Rarely (1–4%) | In 1 condition |
| UGDHUDP-glucose 6-dehydrogenase | Rarely (1–4%) | In 1 condition |
| FGD1FYVE, RhoGEF and PH domain containing 1 | Not recorded | In 1 condition |
| GJA1gap junction protein alpha 1 | Not recorded | In 1 condition |
| NOTCH2notch receptor 2 | Not recorded | In 1 condition |
| PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | Not recorded | In 1 condition |
| ZEB2zinc finger E-box binding homeobox 2 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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