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Trait

Deep wrinkles in soles of feet

Clinical name: Deep plantar creases

The presence of unusually deep creases (ridges/wrinkles) on the skin of sole of foot.

HPO HP:0001869

Summary

Body system
Abnormality of limbsAbnormality of the integument

18 genes linked to Deep wrinkles in soles of feet

Changes in these genes cause rare conditions in which Deep wrinkles in soles of feet is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
MTORmechanistic target of rapamycin kinaseAlwaysIn 1 condition
PIGQphosphatidylinositol glycan anchor biosynthesis class QAlwaysIn 1 condition
RNU2-2RNA, U2 small nuclear 2AlwaysIn 1 condition
TBL1XR1TBL1X/Y related 1AlwaysIn 1 condition
AIPAHR interacting HSP90 co-chaperoneVery often (80–99%)In 1 condition
ATP6V0A2ATPase H+ transporting V0 subunit a2Very often (80–99%)In 2 conditions
GPR101G protein-coupled receptor 101Very often (80–99%)In 1 condition
ABCC9ATP binding cassette subfamily C member 9Often (30–79%)In 1 condition
KCNJ8potassium inwardly rectifying channel subfamily J member 8Often (30–79%)In 1 condition
PRKD1protein kinase D1Often (30–79%)In 1 condition
FBXO11F-box protein 11Sometimes (5–29%)In 1 condition
ATP6V1B2ATPase H+ transporting V1 subunit B2Rarely (1–4%)In 1 condition
KCNH1potassium voltage-gated channel subfamily H member 1Rarely (1–4%)In 1 condition
KCNN3potassium calcium-activated channel subfamily N member 3Rarely (1–4%)In 1 condition
ASXL1ASXL transcriptional regulator 1Not recordedIn 1 condition
HNRNPKheterogeneous nuclear ribonucleoprotein KNot recordedIn 1 condition
HRASHRas proto-oncogene, GTPaseNot recordedIn 1 condition
PIGNphosphatidylinositol glycan anchor biosynthesis class NNot recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

Broader traits

Abnormality of the plantar skin of foot

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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