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Trait

Hyperesthesia

Increased sensitivity to stimulation, excluding the special senses, which may refer to various modes of cutaneous sensibility including touch and thermal sensation without pain, as well as to pain.

HPO HP:0100963

Summary

Also called
Hyperaesthesia
Body system
Abnormality of the nervous system

8 genes linked to Hyperesthesia

Changes in these genes cause rare conditions in which Hyperesthesia is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
FDXRferredoxin reductaseAlwaysIn 1 condition
COL1A1collagen type I alpha 1 chainOften (30–79%)In 1 condition
NF2NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressorOften (30–79%)In 1 condition
GALCgalactosylceramidaseSometimes (5–29%)In 1 condition
PSAPprosaposinSometimes (5–29%)In 1 condition
ATL1atlastin GTPase 1Rarely (1–4%)In 1 condition
HRASHRas proto-oncogene, GTPaseRarely (1–4%)In 1 condition
NTRK1neurotrophic receptor tyrosine kinase 1Rarely (1–4%)In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal exteroceptive sensation

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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