Trait
Low blood sugar
Clinical name: Hypoglycemia
A decreased concentration of glucose in the blood.
Summary
- Also called
- Hypoglycaemia
- Body system
- Laboratory abnormality
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Low blood sugar, and the rest of your genome, with one test.
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Get my Genome Test222 genes linked to Low blood sugar
Changes in these genes cause rare conditions in which Low blood sugar is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ABCC8ATP binding cassette subfamily C member 8 | Always | In 1 condition |
| ALG12ALG12 alpha-1,6-mannosyltransferase | Always | In 1 condition |
| ALPK3alpha kinase 3 | Always | In 1 condition |
| ATIC5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase | Always | In 1 condition |
| ATP5F1DATP synthase F1 subunit delta | Always | In 1 condition |
| BCS1LBCS1 ubiquinol-cytochrome c reductase complex chaperone | Always | In 1 condition |
| CA5Acarbonic anhydrase 5A | Always | In 1 condition |
| COX16cytochrome c oxidase assembly factor COX16 | Always | In 1 condition |
| CYB561cytochrome b561 | Always | In 1 condition |
| DMXL2Dmx like 2 | Always | In 2 conditions |
| FARSBphenylalanyl-tRNA synthetase subunit beta | Always | In 1 condition |
| FBP1fructose-bisphosphatase 1 | Always | In 2 conditions |
| FDXRferredoxin reductase | Always | In 1 condition |
| GCSHglycine cleavage system protein H | Always | In 1 condition |
| GH1growth hormone 1 | Always | In 1 condition |
| GLI2GLI family zinc finger 2 | Always | In 2 conditions |
| GYS1glycogen synthase 1 | Always | In 1 condition |
| HNF4Ahepatocyte nuclear factor 4 alpha | Always | In 1 condition |
| HYOU1hypoxia up-regulated 1 | Always | In 1 condition |
| IARS1isoleucyl-tRNA synthetase 1 | Always | In 1 condition |
| IARS2isoleucyl-tRNA synthetase 2, mitochondrial | Always | In 2 conditions |
| IRF4interferon regulatory factor 4 | Always | In 1 condition |
| KDM6Blysine demethylase 6B | Always | In 1 condition |
| MICOS13mitochondrial contact site and cristae organizing system subunit 13 | Always | In 1 condition |
| MMABmetabolism of cobalamin associated B | Always | In 1 condition |
| MMUTmethylmalonyl-CoA mutase | Always | In 1 condition |
| MRAPmelanocortin 2 receptor accessory protein | Always | In 1 condition |
| MRPS2mitochondrial ribosomal protein S2 | Always | In 1 condition |
| MRPS28mitochondrial ribosomal protein S28 | Always | In 1 condition |
| MRPS7mitochondrial ribosomal protein S7 | Always | In 1 condition |
| NSD1nuclear receptor binding SET domain protein 1 | Always | In 1 condition |
| ODC1ornithine decarboxylase 1 | Always | In 1 condition |
| OTX2orthodenticle homeobox 2 | Always | In 3 conditions |
| PCK1phosphoenolpyruvate carboxykinase 1 | Always | In 1 condition |
| PET100PET100 cytochrome c oxidase chaperone | Always | In 1 condition |
| PEX1peroxisomal biogenesis factor 1 | Always | In 1 condition |
| PGM1phosphoglucomutase 1 | Always | In 1 condition |
| PHKA1phosphorylase kinase regulatory subunit alpha 1 | Always | In 1 condition |
| PTBP1polypyrimidine tract binding protein 1 | Always | In 1 condition |
| RPL17ribosomal protein L17 | Always | In 1 condition |
Show 182 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| RRAGCRas related GTP binding C | Always | In 1 condition |
| SCO1synthesis of cytochrome C oxidase 1 | Always | In 1 condition |
| SLC25A36solute carrier family 25 member 36 | Always | In 1 condition |
| SLC37A4solute carrier family 37 member 4 | Always | In 3 conditions |
| SUCLG1succinate-CoA ligase GDP/ADP-forming subunit alpha | Always | In 2 conditions |
| TEFMtranscription elongation factor, mitochondrial | Always | In 1 condition |
| TFAMtranscription factor A, mitochondrial | Always | In 1 condition |
| UQCC3ubiquinol-cytochrome c reductase complex assembly factor 3 | Always | In 1 condition |
| UQCRBubiquinol-cytochrome c reductase binding protein | Always | In 1 condition |
| UQCRC2ubiquinol-cytochrome c reductase core protein 2 | Always | In 1 condition |
| UQCRHubiquinol-cytochrome c reductase hinge protein | Always | In 1 condition |
| WARS2tryptophanyl tRNA synthetase 2, mitochondrial | Always | In 1 condition |
| AGLamylo-alpha-1,6-glucosidase and 4-alpha-glucanotransferase | Very often (80–99%) | In 2 conditions |
| CPT1Acarnitine palmitoyltransferase 1A | Very often (80–99%) | In 1 condition |
| FOXRED1FAD dependent oxidoreductase domain containing 1 | Very often (80–99%) | In 2 conditions |
| GHSRgrowth hormone secretagogue receptor | Very often (80–99%) | In 1 condition |
| HADHAhydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha | Very often (80–99%) | In 2 conditions |
| HMGCL3-hydroxy-3-methylglutaryl-CoA lyase | Very often (80–99%) | In 1 condition |
| HMGCS23-hydroxy-3-methylglutaryl-CoA synthase 2 | Very often (80–99%) | In 2 conditions |
| INSRinsulin receptor | Very often (80–99%) | In 2 conditions |
| MCCC1methylcrotonyl-CoA carboxylase subunit 1 | Very often (80–99%) | In 2 conditions |
| MCCC2methylcrotonyl-CoA carboxylase subunit 2 | Very often (80–99%) | In 2 conditions |
| MT-ND1mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 | Very often (80–99%) | In 1 condition |
| MT-ND2mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2 | Very often (80–99%) | In 1 condition |
| MT-ND3mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3 | Very often (80–99%) | In 1 condition |
| NDUFA1NADH:ubiquinone oxidoreductase subunit A1 | Very often (80–99%) | In 1 condition |
| NDUFA11NADH:ubiquinone oxidoreductase subunit A11 | Very often (80–99%) | In 1 condition |
| NDUFA6NADH:ubiquinone oxidoreductase subunit A6 | Very often (80–99%) | In 2 conditions |
| NDUFA9NADH:ubiquinone oxidoreductase subunit A9 | Very often (80–99%) | In 1 condition |
| NDUFAF1NADH:ubiquinone oxidoreductase complex assembly factor 1 | Very often (80–99%) | In 1 condition |
| NDUFAF2NADH:ubiquinone oxidoreductase complex assembly factor 2 | Very often (80–99%) | In 1 condition |
| NDUFAF3NADH:ubiquinone oxidoreductase complex assembly factor 3 | Very often (80–99%) | In 1 condition |
| NDUFAF4NADH:ubiquinone oxidoreductase complex assembly factor 4 | Very often (80–99%) | In 1 condition |
| NDUFAF5NADH:ubiquinone oxidoreductase complex assembly factor 5 | Very often (80–99%) | In 1 condition |
| NDUFAF8NADH:ubiquinone oxidoreductase complex assembly factor 8 | Very often (80–99%) | In 1 condition |
| NDUFB10NADH:ubiquinone oxidoreductase subunit B10 | Very often (80–99%) | In 1 condition |
| NDUFB11NADH:ubiquinone oxidoreductase subunit B11 | Very often (80–99%) | In 1 condition |
| NDUFB3NADH:ubiquinone oxidoreductase subunit B3 | Very often (80–99%) | In 1 condition |
| NDUFB9NADH:ubiquinone oxidoreductase subunit B9 | Very often (80–99%) | In 1 condition |
| NDUFS1NADH:ubiquinone oxidoreductase core subunit S1 | Very often (80–99%) | In 1 condition |
| NDUFS2NADH:ubiquinone oxidoreductase core subunit S2 | Very often (80–99%) | In 1 condition |
| NDUFS3NADH:ubiquinone oxidoreductase core subunit S3 | Very often (80–99%) | In 1 condition |
| NDUFS4NADH:ubiquinone oxidoreductase subunit S4 | Very often (80–99%) | In 2 conditions |
| NDUFS6NADH:ubiquinone oxidoreductase subunit S6 | Very often (80–99%) | In 1 condition |
| NDUFS7NADH:ubiquinone oxidoreductase core subunit S7 | Very often (80–99%) | In 1 condition |
| NDUFS8NADH:ubiquinone oxidoreductase core subunit S8 | Very often (80–99%) | In 1 condition |
| NDUFV1NADH:ubiquinone oxidoreductase core subunit V1 | Very often (80–99%) | In 1 condition |
| NDUFV2NADH:ubiquinone oxidoreductase core subunit V2 | Very often (80–99%) | In 1 condition |
| NUBPLNUBP iron-sulfur cluster assembly factor, mitochondrial | Very often (80–99%) | In 1 condition |
| OTCornithine transcarbamylase | Very often (80–99%) | In 1 condition |
| PCCApropionyl-CoA carboxylase subunit alpha | Very often (80–99%) | In 2 conditions |
| PCCBpropionyl-CoA carboxylase subunit beta | Very often (80–99%) | In 2 conditions |
| TIMMDC1translocase of inner mitochondrial membrane domain containing 1 | Very often (80–99%) | In 1 condition |
| TMEM126Btransmembrane protein 126B | Very often (80–99%) | In 1 condition |
| AAASaladin WD repeat nucleoporin | Often (30–79%) | In 1 condition |
| AKT2AKT serine/threonine kinase 2 | Often (30–79%) | In 1 condition |
| ASXL2ASXL transcriptional regulator 2 | Often (30–79%) | In 1 condition |
| CACNA1Ccalcium voltage-gated channel subunit alpha1 C | Often (30–79%) | In 1 condition |
| CDONcell adhesion associated, oncogene regulated | Often (30–79%) | In 1 condition |
| COG7component of oligomeric golgi complex 7 | Often (30–79%) | In 1 condition |
| COX11cytochrome c oxidase copper chaperone COX11 | Often (30–79%) | In 1 condition |
| CPT2carnitine palmitoyltransferase 2 | Often (30–79%) | In 1 condition |
| CYC1cytochrome c1 | Often (30–79%) | In 1 condition |
| DAP3death associated protein 3 | Often (30–79%) | In 1 condition |
| DBHdopamine beta-hydroxylase | Often (30–79%) | In 1 condition |
| DIS3L2DIS3 like 3'-5' exoribonuclease 2 | Often (30–79%) | In 1 condition |
| DLDdihydrolipoamide dehydrogenase | Often (30–79%) | In 2 conditions |
| FAHfumarylacetoacetate hydrolase | Often (30–79%) | In 1 condition |
| FOXA2forkhead box A2 | Often (30–79%) | In 1 condition |
| FUT8fucosyltransferase 8 | Often (30–79%) | In 1 condition |
| GHRgrowth hormone receptor | Often (30–79%) | In 2 conditions |
| GLYCTKglycerate kinase | Often (30–79%) | In 1 condition |
| GMPPAGDP-mannose pyrophosphorylase A | Often (30–79%) | In 1 condition |
| GPC3glypican 3 | Often (30–79%) | In 1 condition |
| GPC4glypican 4 | Often (30–79%) | In 1 condition |
| GPR161G protein-coupled receptor 161 | Often (30–79%) | In 1 condition |
| HADHBhydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta | Often (30–79%) | In 1 condition |
| HESX1HESX homeobox 1 | Often (30–79%) | In 3 conditions |
| HSD17B10hydroxysteroid 17-beta dehydrogenase 10 | Often (30–79%) | In 2 conditions |
| LHX4LIM homeobox 4 | Often (30–79%) | In 4 conditions |
| LRPPRCleucine rich pentatricopeptide repeat containing | Often (30–79%) | In 1 condition |
| MLYCDmalonyl-CoA decarboxylase | Often (30–79%) | In 2 conditions |
| MPV17mitochondrial inner membrane protein MPV17 | Often (30–79%) | In 1 condition |
| MTO1mitochondrial tRNA translation optimization 1 | Often (30–79%) | In 2 conditions |
| NFS1NFS1 cysteine desulfurase | Often (30–79%) | In 1 condition |
| NR1H4nuclear receptor subfamily 1 group H member 4 | Often (30–79%) | In 1 condition |
| PHKA2phosphorylase kinase regulatory subunit alpha 2 | Often (30–79%) | In 2 conditions |
| PHKBphosphorylase kinase regulatory subunit beta | Often (30–79%) | In 1 condition |
| PHKG2phosphorylase kinase catalytic subunit gamma 2 | Often (30–79%) | In 2 conditions |
| PNPOpyridoxamine 5'-phosphate oxidase | Often (30–79%) | In 2 conditions |
| PORcytochrome p450 oxidoreductase | Often (30–79%) | In 1 condition |
| POU1F1POU class 1 homeobox 1 | Often (30–79%) | In 2 conditions |
| PPP1R15Bprotein phosphatase 1 regulatory subunit 15B | Often (30–79%) | In 1 condition |
| PROKR2prokineticin receptor 2 | Often (30–79%) | In 1 condition |
| PROP1PROP paired-like homeobox 1 | Often (30–79%) | In 3 conditions |
| PYGLglycogen phosphorylase L | Often (30–79%) | In 2 conditions |
| RNF125ring finger protein 125 | Often (30–79%) | In 1 condition |
| ROBO1roundabout guidance receptor 1 | Often (30–79%) | In 1 condition |
| SOX3SRY-box transcription factor 3 | Often (30–79%) | In 1 condition |
| STIM1stromal interaction molecule 1 | Often (30–79%) | In 1 condition |
| TANGO2transport and golgi organization 2 homolog | Often (30–79%) | In 2 conditions |
| TFE3transcription factor binding to IGHM enhancer 3 | Often (30–79%) | In 1 condition |
| TRAPPC11trafficking protein particle complex subunit 11 | Often (30–79%) | In 1 condition |
| TRMT10AtRNA methyltransferase 10A | Often (30–79%) | In 1 condition |
| WDR11WD repeat domain 11 | Often (30–79%) | In 1 condition |
| YARS1tyrosyl-tRNA synthetase 1 | Often (30–79%) | In 1 condition |
| ACADMacyl-CoA dehydrogenase medium chain | Sometimes (5–29%) | In 2 conditions |
| ACAT1acetyl-CoA acetyltransferase 1 | Sometimes (5–29%) | In 1 condition |
| ACSF3acyl-CoA synthetase family member 3 | Sometimes (5–29%) | In 1 condition |
| ATP7AATPase copper transporting alpha | Sometimes (5–29%) | In 1 condition |
| AUHAU RNA binding methylglutaconyl-CoA hydratase | Sometimes (5–29%) | In 1 condition |
| CAMKMTcalmodulin-lysine N-methyltransferase | Sometimes (5–29%) | In 1 condition |
| CDKN1Ccyclin dependent kinase inhibitor 1C | Sometimes (5–29%) | In 1 condition |
| COG8component of oligomeric golgi complex 8 | Sometimes (5–29%) | In 1 condition |
| CTDP1CTD phosphatase 1 | Sometimes (5–29%) | In 1 condition |
| DDCdopa decarboxylase | Sometimes (5–29%) | In 1 condition |
| FBXO22F-box protein 22 | Sometimes (5–29%) | In 1 condition |
| GALTgalactose-1-phosphate uridylyltransferase | Sometimes (5–29%) | In 1 condition |
| GATBglutamyl-tRNA amidotransferase subunit B | Sometimes (5–29%) | In 1 condition |
| GATCglutamyl-tRNA amidotransferase subunit C | Sometimes (5–29%) | In 1 condition |
| GFM1G elongation factor mitochondrial 1 | Sometimes (5–29%) | In 1 condition |
| GJA1gap junction protein alpha 1 | Sometimes (5–29%) | In 1 condition |
| H19H19 imprinted maternally expressed transcript | Sometimes (5–29%) | In 1 condition |
| HMGA2high mobility group AT-hook 2 | Sometimes (5–29%) | In 1 condition |
| IGF1insulin like growth factor 1 | Sometimes (5–29%) | In 1 condition |
| IGF2insulin like growth factor 2 | Sometimes (5–29%) | In 2 conditions |
| KDM6Alysine demethylase 6A | Sometimes (5–29%) | In 1 condition |
| KMT2Dlysine methyltransferase 2D | Sometimes (5–29%) | In 1 condition |
| LHX3LIM homeobox 3 | Sometimes (5–29%) | In 1 condition |
| MMACHCmetabolism of cobalamin associated C | Sometimes (5–29%) | In 1 condition |
| NR3C1nuclear receptor subfamily 3 group C member 1 | Sometimes (5–29%) | In 2 conditions |
| OPLAH5-oxoprolinase, ATP-hydrolysing | Sometimes (5–29%) | In 1 condition |
| PCpyruvate carboxylase | Sometimes (5–29%) | In 1 condition |
| PLAG1PLAG1 zinc finger | Sometimes (5–29%) | In 1 condition |
| PPM1Bprotein phosphatase, Mg2+/Mn2+ dependent 1B | Sometimes (5–29%) | In 1 condition |
| PPP2R5Dprotein phosphatase 2 regulatory subunit B'delta | Sometimes (5–29%) | In 2 conditions |
| PREPLprolyl endopeptidase like | Sometimes (5–29%) | In 1 condition |
| PTENphosphatase and tensin homolog | Sometimes (5–29%) | In 1 condition |
| QRSL1glutaminyl-tRNA amidotransferase subunit QRSL1 | Sometimes (5–29%) | In 1 condition |
| SLC3A1solute carrier family 3 member 1 | Sometimes (5–29%) | In 1 condition |
| SNIP1Smad nuclear interacting protein 1 | Sometimes (5–29%) | In 1 condition |
| TRPM3transient receptor potential cation channel subfamily M member 3 | Sometimes (5–29%) | In 1 condition |
| ALDH7A1aldehyde dehydrogenase 7 family member A1 | Rarely (1–4%) | In 1 condition |
| EHHADHenoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase | Rarely (1–4%) | In 1 condition |
| FHfumarate hydratase | Rarely (1–4%) | In 1 condition |
| GALK1galactokinase 1 | Rarely (1–4%) | In 1 condition |
| GATMglycine amidinotransferase | Rarely (1–4%) | In 1 condition |
| MT-CYBmitochondrially encoded cytochrome b | Rarely (1–4%) | In 1 condition |
| NAB2NGFI-A binding protein 2 | Rarely (1–4%) | In 1 condition |
| NDUFAF6NADH:ubiquinone oxidoreductase complex assembly factor 6 | Rarely (1–4%) | In 1 condition |
| PLPBPpyridoxal phosphate binding protein | Rarely (1–4%) | In 1 condition |
| SLC34A1solute carrier family 34 member 1 | Rarely (1–4%) | In 1 condition |
| STAT6signal transducer and activator of transcription 6 | Rarely (1–4%) | In 1 condition |
| ACAD9acyl-CoA dehydrogenase family member 9 | Not recorded | In 1 condition |
| ACADSBacyl-CoA dehydrogenase short/branched chain | Not recorded | In 1 condition |
| ALDOBaldolase, fructose-bisphosphate B | Not recorded | In 1 condition |
| BCKDHAbranched chain keto acid dehydrogenase E1 subunit alpha | Not recorded | In 1 condition |
| CYP21A2cytochrome P450 family 21 subfamily A member 2 | Not recorded | In 1 condition |
| DGUOKdeoxyguanosine kinase | Not recorded | In 1 condition |
| EIF2S3eukaryotic translation initiation factor 2 subunit gamma | Not recorded | In 1 condition |
| ETFAelectron transfer flavoprotein subunit alpha | Not recorded | In 1 condition |
| ETFBelectron transfer flavoprotein subunit beta | Not recorded | In 1 condition |
| ETFDHelectron transfer flavoprotein dehydrogenase | Not recorded | In 1 condition |
| G6PC1glucose-6-phosphatase catalytic subunit 1 | Not recorded | In 1 condition |
| GCDHglutaryl-CoA dehydrogenase | Not recorded | In 1 condition |
| GKglycerol kinase | Not recorded | In 1 condition |
| HRASHRas proto-oncogene, GTPase | Not recorded | In 1 condition |
| KCNJ11potassium inwardly rectifying channel subfamily J member 11 | Not recorded | In 1 condition |
| MEN1menin 1 | Not recorded | In 1 condition |
| MPC1mitochondrial pyruvate carrier 1 | Not recorded | In 1 condition |
| MTORmechanistic target of rapamycin kinase | Not recorded | In 1 condition |
| NBASNBAS subunit of NRZ tethering complex | Not recorded | In 1 condition |
| NFKB2nuclear factor kappa B subunit 2 | Not recorded | In 1 condition |
| NNTnicotinamide nucleotide transhydrogenase | Not recorded | In 1 condition |
| PCK2phosphoenolpyruvate carboxykinase 2, mitochondrial | Not recorded | In 1 condition |
| PTF1Apancreas associated transcription factor 1a | Not recorded | In 1 condition |
| SAMD9sterile alpha motif domain containing 9 | Not recorded | In 1 condition |
| SERAC1serine active site containing 1 | Not recorded | In 1 condition |
| SGPL1sphingosine-1-phosphate lyase 1 | Not recorded | In 1 condition |
| SLC16A1solute carrier family 16 member 1 | Not recorded | In 1 condition |
| SLC25A20solute carrier family 25 member 20 | Not recorded | In 1 condition |
| SLC52A1solute carrier family 52 member 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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