Trait
Brittle nails
Clinical name: Fragile nails
Nails that easily break.
Summary
- Body system
- Abnormality of the integument
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Brittle nails, and the rest of your genome, with one test.
From $449Free shipping · Results in 6–8 weeks
Get my Genome Test35 genes linked to Brittle nails
Changes in these genes cause rare conditions in which Brittle nails is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| HEPHL1hephaestin like 1 | Always | In 1 condition |
| ITPR3inositol 1,4,5-trisphosphate receptor type 3 | Always | In 1 condition |
| COL7A1collagen type VII alpha 1 chain | Very often (80–99%) | In 1 condition |
| LMNAlamin A/C | Very often (80–99%) | In 1 condition |
| MSX1msh homeobox 1 | Very often (80–99%) | In 1 condition |
| ATP2A2ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 | Often (30–79%) | In 1 condition |
| DLX3distal-less homeobox 3 | Often (30–79%) | In 2 conditions |
| KRT14keratin 14 | Often (30–79%) | In 2 conditions |
| PRKD1protein kinase D1 | Often (30–79%) | In 1 condition |
| SMARCD2SWI/SNF related BAF chromatin remodeling complex subunit D2 | Often (30–79%) | In 1 condition |
| TRPS1transcriptional repressor GATA binding 1 | Often (30–79%) | In 1 condition |
| AARS1alanyl-tRNA synthetase 1 | Sometimes (5–29%) | In 1 condition |
| CARS1cysteinyl-tRNA synthetase 1 | Sometimes (5–29%) | In 1 condition |
| DBR1debranching RNA lariats 1 | Sometimes (5–29%) | In 1 condition |
| DSPdesmoplakin | Sometimes (5–29%) | In 1 condition |
| ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit | Sometimes (5–29%) | In 2 conditions |
| ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit | Sometimes (5–29%) | In 1 condition |
| FOSL2FOS like 2, AP-1 transcription factor subunit | Sometimes (5–29%) | In 1 condition |
| FTLferritin light chain | Sometimes (5–29%) | In 1 condition |
| GTF2E2general transcription factor IIE subunit 2 | Sometimes (5–29%) | In 1 condition |
| GTF2H5general transcription factor IIH subunit 5 | Sometimes (5–29%) | In 1 condition |
| MPLKIPM-phase specific PLK1 interacting protein | Sometimes (5–29%) | In 1 condition |
| RNF113Aring finger protein 113A | Sometimes (5–29%) | In 1 condition |
| SIN3ASIN3 transcription regulator family member A | Sometimes (5–29%) | In 2 conditions |
| SIN3BSIN3 transcription regulator family member B | Sometimes (5–29%) | In 1 condition |
| TARS1threonyl-tRNA synthetase 1 | Sometimes (5–29%) | In 1 condition |
| CAMK2Gcalcium/calmodulin dependent protein kinase II gamma | Rarely (1–4%) | In 1 condition |
| AP1B1adaptor related protein complex 1 subunit beta 1 | Not recorded | In 1 condition |
| ATP6V0A2ATPase H+ transporting V0 subunit a2 | Not recorded | In 1 condition |
| COL17A1collagen type XVII alpha 1 chain | Not recorded | In 1 condition |
| EFNB1ephrin B1 | Not recorded | In 1 condition |
| GJA1gap junction protein alpha 1 | Not recorded | In 1 condition |
| HRASHRas proto-oncogene, GTPase | Not recorded | In 1 condition |
| LAMB3laminin subunit beta 3 | Not recorded | In 1 condition |
| SLURP1secreted LY6/PLAUR domain containing 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
One test. A lifetime of answers.
From $449Free shipping · Results in 6–8 weeks